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Chakraborty D.,University Hospital and Medical | Chakraborty D.,Max Planck Institute of Molecular Cell Biology and Genetics | Kappei D.,University Hospital and Medical | Kappei D.,Max Planck Institute of Molecular Cell Biology and Genetics | And 17 more authors.
Nature Methods | Year: 2012

Whereas methods to comprehensively study cellular roles of protein-coding genes are available, techniques to systematically investigate long noncoding RNAs (lncRNAs), which have been implicated in diverse biological pathways, are limited. Here we report combined knockdown and localization analysis of noncoding RNAs (c-KLAN) that merges functional characterization and localization approaches to study lncRNAs. Using this technique we identified transcripts that regulate mouse embryonic stem cell identity. © 2012 Nature America, Inc. All rights reserved. Source

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