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Xue J.,University for International Cooperation
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

The main purpose of genericity in high lever programming language is to increase efficiency of software development and the safety and reusability of software. Genericity is the useful tool to implement generative software development and MDA. However, few modelling language has genericity mechanism and the mechanisms in typical programming language, say C++, Java, etc., is not sufficiently and is not ease to use. The situation in PAR platform is quite different. PAR platform supports Model Driven Software Engineering (MDE) and consists of algorithm modelling language Radl, abstract program modelling language Apla, a set of rules for the model transformation and a set of automatic transformation tools of algorithm model and program model. One of the distinct features of the PAR platform is the agile genericity mechanisms. In PAR not only a value, a data type and a computing-action (including operator, method, function and procedure, etc.) can be generic parameter, an ADT can be generic parameter also. We present new concepts, say type region, action region and ADT region, which can increase the safety of generic software obviously. The paper will pay special attention to describe the syntax and semantics of the ADT parameter. The case study describes the method to develop generic program with ADT as parameter. © Springer International Publishing Switzerland 2016. Source

Wu S.,Shanghai University | Wu F.,University for International Cooperation | Hong R.,Fujian Center for Disease Control and Prevetion | He J.,Shanghai University
PLoS ONE | Year: 2012

Background: There is limited epidemiologic information about the incidence of hepatitis C in China, and few studies have applied space-time scan statistic to detect clusters of hepatitis C and made adjustment for temporal trend and relative risk of regions. Methodology and Principal Findings: We analyzed the temporal changes and characteristics of incidence of hepatitis C in Fujian Province from 2006 through 2010. The discrete Poisson model of space-time scan statistic was chosen for cluster detection. Data on new cases of hepatitis C were obtained from the Center for Disease Control and Prevention of Fujian Province. Between 2006 and 2010, there was an annualized increase in the incidence of hepatitis C of 23.0 percent, from 928 cases (2.63 per 100,000 persons) to 2,180 cases (6.01 per 100,000 persons). The incidence among women increased more rapidly. The cumulative incidence showed that people who were over 60 years had the highest risk to suffer hepatitis C (52.51 per 100,000 persons), and women had lower risk compared to men (OR = 0.69). Putian had the highest cumulative incidence among all the regions (86.95 per 100,000 persons). The most likely cluster was identified in Putian during March to August in 2009 without adjustment, but it shifted to three contiguous cities with a two-month duration after adjustment for temporal trend and relative risk of regions. Conclusions/Significance: The incidence of hepatitis C is increasing in Fujian Province, and women are at a more rapid pace. The space-time scan statistic is useful as a screening tool for clusters of hepatitis C, with adjustment for temporal trend and relative risk of regions recommended. © 2012 Wu et al. Source

Chung N.T.,University for International Cooperation | Toan H.Q.,Hanoi University of Science
Nonlinear Analysis: Real World Applications | Year: 2014

This article investigates a class of anisotropic elliptic equations with non-standard growth conditions {-Σi= 1N∂xi(|∂xiu|pi(x)- 2∂xiu)=f(x,u)in Ω,u=0on ∂Ω, where ΩâŠRN (N≥3) is a bounded domain with smooth boundary ∂Ω, and pi, i=1,2,.,N are continuous functions on Ω̄ such that 1 Source

Yu L.X.,University for International Cooperation
Hepatology (Baltimore, Md.) | Year: 2010

Increasing evidence suggests that the presence of endotoxemia is of substantial clinical relevance to patients with cirrhosis, but it is unclear whether and how gut-derived LPS amplifies the tumorigenic response of the liver. We found that the circulating levels of LPS were elevated in animal models of carcinogen-induced hepatocarcinogenesis. Reduction of LPS using antibiotics regimen in rats or genetic ablation of its receptor Toll-like receptor 4 (TLR4) in mice prevented excessive tumor growth and multiplicity. Additional investigation revealed that TLR4 ablation sensitizes the liver to carcinogen-induced toxicity via blocking NF-κB activation and sensitizing the liver to reactive oxygen species (ROS)-induced toxicity, but lessens inflammation-mediated compensatory proliferation. Reconstitution of TLR4-expressing myeloid cells in TLR4-deficient mice restored diethylnitrosamine (DEN)-induced hepatic inflammation and proliferation, indicating a paracrine mechanism of LPS in tumor promotion. Meanwhile, deletion of gut-derived endotoxin suppressed DEN-induced cytokine production and compensatory proliferation, whereas in vivo LPS pre-challenge promotes hepatocyte proliferation. CONCLUSION: Our data indicate that sustained LPS accumulation represents a pathological mediator of inflammation-associated hepatocellular carcinoma (HCC) and manipulation of the gut flora to prevent pathogenic bacterial translocation and endotoxin absorption may favorably influence liver function in patients with cirrhosis who are at risk of developing HCC. Source

Wu S.,Research and Technology Service Center | Ding Y.,Shanghai University | Wu F.,University for International Cooperation | Li R.,Research and Technology Service Center | And 2 more authors.
Neuroscience and Biobehavioral Reviews | Year: 2015

Background: We systematically reviewed the association of omega-3 fatty acids intake with the incidence of dementia and Alzheimer's disease (AD) in this meta-analysis of prospective cohort studies, as evidence from previous studies suggests inconsistent results. Methods: We identified relevant studies by searching PubMed, EmBase, and Web of Science databases up to June 2013. Prospective cohort studies reporting on associations of dietary intake of long-chain omega-3 fatty acids or fish with the incidence of dementia and AD were eligible. Results: Comparing the highest to lowest category of long-chain omega-3 fatty acids intake and fish intake, the pooled relative risks (RRs) for dementia were 0.97 (95% CI 0.85-1.10) and 0.84 (95% CI 0.71-1.01), respectively. Evidence synthesis for AD risk did not show a statistically significant association with long-chain omega-3 fatty acids intake (RR = 0.89, 95% CI 0.74-1.08). However, a higher intake of fish was associated with a 36% (95% CI 8-56%) lower risk of AD. Dose-response meta-analysis showed that an increment of 100. g per week of fish intake was associated with an 11% lower risk of AD (RR = 0.89, 95% CI 0.79-0.99). There was limited evidence of heterogeneity across studies or within subgroups. Conclusion: A higher intake of fish was associated with a lower risk of AD. However, there was no statistical evidence for similar inverse association between long-chain omega-3 fatty acids intake and risk of dementia or AD, nor was there inverse association between fish intake and risk of dementia. © 2014 Elsevier Ltd. Source

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