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Bianco H.T.,Federal University of Sao Paulo | Izar M.C.,Federal University of Sao Paulo | Fonseca H.A.,Federal University of Sao Paulo | Povoa R.M.,Federal University of Sao Paulo | And 5 more authors.
Arquivos Brasileiros de Cardiologia | Year: 2014

Background: Patients with diabetes are in extract higher risk for fatal cardiovascular events.Objective: To evaluate major predictors of mortality in subjects with type 2 diabetes.Methods: A cohort of 323 individuals with type 2 diabetes from several regions of Brazil was followed for a long period. Baseline electrocardiograms, clinical and laboratory data obtained were used to determine hazard ratios (HR) and confidence interval (CI) related to cardiovascular and total mortality.Results: After 9.2 years of follow-up (median), 33 subjects died (17 from cardiovascular causes). Cardiovascular mortality was associated with male gender; smoking; prior myocardial infarction; long QTc interval; left ventricular hypertrophy; and eGFR <60 mL/min. These factors, in addition to obesity, were predictors of total mortality. Cardiovascular mortality was adjusted for age and gender, but remained associated with: smoking (HR = 3.8; 95% CI 1.3-11.8; p = 0.019); prior myocardial infarction (HR = 8.5; 95% CI 1.8-39.9; p = 0.007); eGFR < 60 mL/min (HR = 9.5; 95% CI 2.7-33.7; p = 0.001); long QTc interval (HR = 5.1; 95% CI 1.7-15.2; p = 0.004); and left ventricular hypertrophy (HR = 3.5; 95% CI 1.3-9.7; p = 0.002). Total mortality was associated with obesity (HR = 2.3; 95% CI 1.1-5.1; p = 0.030); smoking (HR = 2.5; 95% CI 1.0-6.1; p = 0.046); prior myocardial infarction (HR = 3.1; 95% CI 1.4-6.1; p = 0.005), and long QTc interval (HR = 3.1; 95% CI 1.4-6.1; p = 0.017).Conclusions: Biomarkers of simple measurement, particularly those related to target-organ lesions, were predictors of mortality in subjects with type 2 diabetes. © 2014, Arquivos Brasileiros de Cardiologia. All rights reserved. Source

Alves J.M.,Instituto Federal Goiano | Leandro W.M.,University Federal Of Goiania | Alves C.C.F.,Instituto Federal Goiano | Carlos L.,Instituto Federal Goiano | And 2 more authors.
Revista Brasileira de Engenharia Agricola e Ambiental | Year: 2016

Crambe has been studied as an option in crop rotation systems in order to provide raw material for biodiesel production. This study aimed to evaluate the effect of raising soil base saturation and addition of phosphorus (P) on the vegetative development, grain yield and oil content of crambe. The experiment was carried out in a Oxisol, arranged in factorial scheme (4 x 3), with 4 replicates (48 plots), in completely randomized blocks. Four base saturation levels (34 - natural of the soil, 40, 50 and 60%) and three P doses (0, 40 and 80 kg ha-1 of P2O5) were evaluated. The experimental plots formed a 9 m2 rectangle with 5 plant rows, spaced by 0.45 m, using the cultivar “Brilliant FMS”. The evaluated variables were: dry matter of roots and shoots at three different times (35, 45 and 55 days after emergence), grain yield and oil content. Base saturation favored crambe root and shoot development, yield and oil content, with the best results for base saturation of 47-48%. The addition of P doses also favored the increase of the analyzed variables. © 2016, Departamento de Engenharia Agricola - UFCG/Cnpq. All rights reserved. Source

Gomes S.M.C.,University of Coimbra | Ghica M.-E.,University of Coimbra | Rodrigues I.A.,University of Coimbra | Rodrigues I.A.,Federal University of Maranhao | And 3 more authors.
Talanta | Year: 2016

Phenolic compounds detection in fruit extracts from: açai, bacuri, buriti, blackberry, black mulberry, blueberry, juçara, physalis, raspberry, and tamarillo, have been performed by reverse-phase high performance liquid chromatography with electrochemical detection (RP-HPLC-EC), using two detectors in series: a wall-jet detector flow cell with a glassy carbon electrode, and a thin-layer flow cell detector with a boron doped diamond electrode. This methodology, in gradient elution mode, was successfully used to detect seventeen phenolic compounds in the fruit extracts. The total antioxidant capacity of the fruit extracts by the electrochemical quantitative index (EI) and the method of capture of diphenilpicrilhydrazil (DPPH•) free radical "efficient concentration" (EC50), was evaluated. A very good correlation between EI and EC50 assays has been obtained, the fruit with the highest total antioxidant capacity being blackberry, while physalis exhibited the lowest antioxidant power. © 2016 Elsevier B.V. All rights reserved. Source

Fragoso Y.D.,Metropolitan University of Santos | Boggild M.,Walton Center | MacIas-Islas M.A.,University of Guadalajara | Carra A.,Hospital Britanico de Buenos Aires | And 35 more authors.
Clinical Neurology and Neurosurgery | Year: 2013

Background and objective: Women with multiple sclerosis (MS) who intend to get pregnant are often advised to discontinue disease modifying therapy (DMT) prior to conception. This recommendation is not based on medical evidence and may interfere with disease control by immunomodulatory drugs. The present study was designed to help discuss the effect of DMT for MS on pregnancy and on disease course. Patients and methods: Retrospective data from 152 pregnancies of 132 women with MS were collected by the physician in charge of the case. All data were entered into a specific file for qualitative and quantitative statistical analysis. Results: From the total group of patients, 89 pregnancies occurred without any exposure to MS drugs, while 61 pregnancies occurred with at least eight weeks of exposure to MS immunomodulatory drugs. The rate of obstetric and neonatal complications was similar in both groups, except for the newborn weight and height which was smaller for mothers receiving medications. Mothers' post-delivery relapse rate and EDSS scores in the follow-up period were significantly higher in the absence of treatment. Conclusion: It is possible that, with further such supportive data, international guidelines on MS treatment in young women who intend to get pregnant may need to be revised. © 2012 Elsevier B.V. Source

Heberly F.B.,Federal University of Uberlandia | Ferreira I.M.,LABIO FAMEVUFU | Leal G.S.,University Federal Of Goiania | Fonseca B.B.,Federal University of Uberlandia | Rossi D.A.,LABIO FAMEV UFU
Bioscience Journal | Year: 2010

The kibe mass pass to an intensive handling, being exposed to several hazards on microbial contamination opportunities. These contaminations can conduct to product deterioration or offer risks to the costumers' health. The inadequate hygiene conditions and storage emphasize this problematic system. The study aimed to determine the kibe mass contamination by bacterial from thermotolerants coliforms, Staphylococcus positive coagulase andSalmonella spp., of the kibe masses commercialized in five geographic sectors of the Uberlândia-MG; ascertain the suitability of the product's specifications to ANVISA, and the main risks related to contamination by thermotolerant. 42% of the analyzed samples (21/50) were found as unsatisfactory due termotolerant coliforms (38%) above permissible legislation values and Salmonella spp. presence (4%). No samples showed inadequate counting of Staphylococcus positivecoagulase. Risk factors positively related to contamination by fecal coliform were: distribution and organization of food atthe counter refrigerator (P = 0.002, OR = 3.21), hygiene and maintenance of vessels (P = 0.26, OR = 2, 02) and air (P = 0.09, OR = 2.72). None of the risk analysis was directly associated with the presence of Salmonella spp. Source

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