Castro A.J.,Federal University of Santa Catarina |
Castro A.J.,University Federal da Fronteira Sul |
Castro A.J.,Federal University of Rio de Janeiro
Biochimica et biophysica acta | Year: 2015
BACKGROUND: The effect of in vivo treatment with ursolic acid (UA) on glycemia in hyperglycemic rats and its mechanism of action on muscle were studied.METHODS: The UA effects on glycemia, glycogen, LDH, calcium and on insulin levels were evaluated after glucose tolerance curve. The β-cells were evaluated through the transmission electron microscopy. UA mechanism of action was studied on muscles through the glucose uptake with/without specific insulin signaling inhibitors. The nuclear effect of UA and the GLUT4 expression on muscle were studied using thymidine, GLUT4 immunocontent, immunofluorescence and RT-PCR.RESULTS: UA presented a potent antihyperglycemic effect, increased insulin vesicle translocation, insulin secretion and augmented glycogen content. Also, UA stimulates the glucose uptake through the involvement of the classical insulin signaling related to the GLUT4 translocation to the plasma membrane as well as the GLUT4 synthesis. These were characterized by increasing the GLUT4 mRNA expression, the activation of DNA transcription, the expression of GLUT4 and its presence at plasma membrane. Also, the modulation of calcium, phospholipase C, protein kinase C and PKCaM II is mandatory for the full stimulatory effect of UA on glucose uptake. UA did not change the serum LDH and serum calcium balance.CONCLUSIONS: The antihyperglycemic role of UA is mediated through insulin secretion and insulinomimetic effect on glucose uptake, synthesis and translocation of GLUT4 by a mechanism of cross-talk between calcium and protein kinases.GENERAL SIGNIFICANCE: UA is a potential anti-diabetic agent with pharmacological properties for insulin resistance and diabetes therapy. Copyright © 2014 Elsevier B.V. All rights reserved.
Alloy M.D.,University Federal da Fronteira Sul |
Menezes D.P.,Federal University of Santa Catarina
Physical Review C - Nuclear Physics | Year: 2011
In this paper, we calculate the diffusion coefficients that are related to the neutrino opacities considering the formation of nuclear pasta and homogeneous matter at low densities. Our results show that the mean-free paths are significantly altered by the presence of nuclear pasta in stellar matter when compared with the results obtained with homogeneous matter. These differences in neutrino opacities certainly influence the Kelvin-Helmholtz phase of protoneutron stars and consequently the results of supernova explosion simulations. © 2011 American Physical Society.
Cintra R.J.,Federal University of Pernambuco |
Cintra R.J.,University of Akron |
Bayer F.M.,University Federal da Fronteira Sul
IEEE Signal Processing Letters | Year: 2011
An orthogonal approximation for the 8-point discrete cosine transform (DCT) is introduced. The proposed transformation matrix contains only zeros and ones; multiplications and bit-shift operations are absent. Close spectral behavior relative to the DCT was adopted as design criterion. The proposed algorithm is superior to the signed discrete cosine transform. It could also outperform state-of-the-art algorithms in low and high image compression scenarios, exhibiting at the same time a comparable computational complexity. © 2006 IEEE.
Ignacio Z.M.,University of the Extreme South of Santa Catarina |
Ignacio Z.M.,University Federal da Fronteira Sul |
Reus G.Z.,University of the Extreme South of Santa Catarina |
Reus G.Z.,University of Texas Health Science Center at Houston |
And 3 more authors.
Neuroscience | Year: 2014
Epidemiological studies have shown significant results in the interaction between the functions of brain-derived neurotrophic factor (BDNF) and 5-HT in mood disorders, such as major depressive disorder (MDD). The latest research has provided convincing evidence that gene transcription of these molecules is a target for epigenetic changes, triggered by stressful stimuli that starts in early childhood and continues throughout life, which are subsequently translated into structural and functional phenotypes culminating in depressive disorders. The short variants of 5-HTTLPR and BDNF-Met are seen as forms which are predisposed to epigenetic aberrations, which leads individuals to a susceptibility to environmental adversities, especially when subjected to stress in early life. Moreover, the polymorphic variants also feature epistatic interactions in directing the functional mechanisms elicited by stress and underlying the onset of depressive disorders. Also emphasized are works which show some mediators between stress and epigenetic changes of the 5-HTT and BDNF genes, such as the hypothalamic-pituitary-adrenal (HPA) axis and the cAMP response element-binding protein (CREB), which is a cellular transcription factor. Both the HPA axis and CREB are also involved in epistatic interactions between polymorphic variants of 5-HTTLPR and Val66Met.This review highlights some research studying changes in the epigenetic patterns intrinsic to genes of 5-HTT and BDNF, which are related to lifelong environmental adversities, which in turn increases the risks of developing MDD. © 2014 IBRO.
Lima A.G.,State University of the Central West |
Binda A.L.,University Federal da Fronteira Sul
Journal of South American Earth Sciences | Year: 2013
Knickzones are common features along rivers on the basaltic plateaus of the Paraná Basin. According to current conceptual models, knickpoints are formed in massive basalts that have a high density of vertical joints. Vesicular-amygdaloidal basalts and those with horizontal joints tend to form reaches of low slope due to their lower resistance to erosion. However, field surveys revealed complexities in this general relationship. The research presented here sought to verify the controls on the genesis of knickzones in this type of geological environment. We studied a 61km-long mixed bedrock-alluvial river. The longitudinal profile of the river was surveyed on a topographic map with 5m contour intervals. Tectonic lineaments oriented transverse to the channel and longitudinal lineaments in which the river lies were identified from maps. A detailed field survey of the lithologic characteristics of the riverbed was also performed. The results show that knickzones may form in any litho-structural zone in the flood basalts. On the other hand, low slope zones are predominantly sculpted into vesicular-amygdaloidal basalts, which are less resistant to erosion. The fracture densities of vesicular-amygdaloidal basalts are similar in low slope zones and in knickzones (4.86 and 4.93m/m2, respectively). This indicates that knickzones in this type of basalt are not caused by higher resistance to erosion. Approximately 60% of the 18 knickzones identified are associated with tectonic lineaments, irrespective of the structural characteristics of the basalts. Vesicular-amygdaloidal basalt and/or basalt with horizontal joints allow the fastest knickzone migration and aid in the formation of convexities. Knickpoints in these basalts do not migrate, but erosion in the pools advances downstream and breaks the bedrock steps, thus increasing the slope. Massive basalt with vertical joints causes slower migration, and its presence at convexities indicates local uplift. Convex segments are only formed upstream of faults. © 2013 Elsevier Ltd.