Parent-Massin D.,University Europeene Of Bretagne |
Hymery N.,University Europeene Of Bretagne |
Sibiril Y.,University Europeene Of Bretagne
Toxicology | Year: 2010
Myelotoxicity describes bone marrow failure due to adverse effect of xenobiotic on hematopoiesis. Hematopoiesis is a complex system in which pluripotent hematopoietic stem cells (PHSCs) differentiate into many highly specialized circulating blood cells involving the interaction of many cell types as well as the interaction of local and systemic growth factors. With respect to blood cell formation, two functional systems must be considered: the hematopoietic stem cells (PHSCs) and the progenitor cells, on one hand, and the stromal cells, which constitute the hematopoietic environment niche, on the other hand. There are three types of assays for hematopoietic progenitor clonogenic assays useable in myelotoxicology: CFU-GM assay for Colony Forming Unit Granulocyte and Macrophage, BFU-E assay for Burst Forming Unit Erythroid, and CFU-MK assay for Colony Forming Unit Megakaryocyte from several species as well as from murine as from mammalian and human. Clonogenic assays have been used to detect myelotoxicity induced by chemicals, drug, food and environmental contaminants. Designs and applications are described in this review. © 2009.
Stephanie B.,University Europeene Of Bretagne |
Stephanie B.,University of Western Brittany |
Eric D.,University Europeene Of Bretagne |
Eric D.,University of Western Brittany |
And 4 more authors.
Carbohydrate Polymers | Year: 2010
The investigations reported here are about a carrageenan extracted from the abundant red alga, Solieria chordalis (Gigartinales) settled along the coasts of Brittany. Its structural features were characterized by GC-MS, 13C NMR and FTIR spectroscopies. The structural components of this polysaccharide are mainly a (DA2S-G4S)-type structure in association with methylated-ι-carrageenan, pyruvated α-carrageenan and the minor precursor, ν-carrageenen, in small amounts. The relative molecular weight of the native polysaccharide was estimated by LP-GPC as 913 kDa. The low molecular weight fractions (below 20 kDa) obtained by free-radical depolymerization and mild-acid hydrolysis presented substitution patterns similar to those of the native polysaccharide. These fractions proved to be devoid of direct cytotoxicity on Daudi (human Burkitt's lymphoma), Jurkat (human leukaemic T-cell lymphoblast) and K562 (human chronic myelogenous leukaemia) cells lines. On the other hand, they showed great immunostimulating properties: enhancement of neutrophil phagocytosis, cytotoxicity by natural killer cells, antibody-dependent cell cytotoxicity and stimulation of lymphocyte proliferation. Further to these investigations, it could be worth using the low molecular weight fractions of carrageenan from the red alga, S. chordalis, in immunotherapeutic approaches to cancer treatment. Crown Copyright © 2010.
Azou S.,University Europeene Of Bretagne |
Azou S.,CNRS Communication and Information Sciences Laboratories |
Radoi E.,University Europeene Of Bretagne |
Radoi E.,CNRS Communication and Information Sciences Laboratories
2012 9th International Conference on Communications, COMM 2012 - Conference Proceedings | Year: 2012
This paper deals with timing recovery for Impulse Radio (IR) ultra-wideband (UWB) communication systems, which is known to be a challenging task to accomplish. We focus on blind estimation approaches, with the aim of being able to operate with minimal constraints on the signal format (no use of pilot symbols). We consider also the blind timing estimation problem in the sense that no prior knowledge is needed on the modulation parameters. The proposed methods may contribute to develop flexible receivers, capable of synchronizing various IR-UWB signal formats from short data records, even if some key parameters are changed over time. © 2012 IEEE.
Lodde B.,University Europeene Of Bretagne
International maritime health | Year: 2010
When death at sea occurs many people are implicated. The assignees of victims often look for detailed circumstances of deaths at sea, and the doctor, besides his preventative role, has to certify the death on board and try to determine the circumstances with a view to a legal investigation if it proves necessary. In this work are presented the main causes, facts, and characteristics of human deaths at sea, and the responsibility of the ship's doctor in case of death on board.