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do Carmo J.M.,University of Mississippi Medical Center | da Silva A.A.,University of Ribeirão Preto | da Silva A.A.,University Estadual Of Minas Gerais | Wang Z.,University of Mississippi Medical Center | And 4 more authors.
Biochimica et Biophysica Acta - Molecular Basis of Disease | Year: 2017

Melanocortins play an important role in regulating blood pressure (BP) and sympathetic nervous system (SNS) activity as well as energy balance, glucose and other metabolic functions in humans and experimental animals. In experimental models of hypertension with high SNS activity, blockade of the melanocortin-4 receptor (MC4R) reduces BP despite causing marked hyperphagia and obesity. Activation of the central nervous system (CNS) pro-opiomelanocortin (POMC)-MC4R pathway appears to be an important link between obesity, SNS activation and hypertension. Despite having severe obesity, subjects with MC4R deficiency exhibit reductions in BP, heart rate, and urinary catecholamine excretion, as well as attenuated SNS responses to cold stimuli compared to obese subjects with normal MC4R function. In this review we discuss the importance of the brain POMC-MC4R system in regulating SNS activity and BP in obesity and other forms of hypertension. We also highlight potential mechanisms and brain circuitry by which the melanocortin system regulates cardiovascular function. © 2017 Elsevier B.V.


Fonseca A.R.,University Estadual Of Minas Gerais | Campos R.B.F.,University Estadual Of Minas Gerais
Acta Scientiarum - Health Sciences | Year: 2010

Urban ants, when present in hospital environments, can be a potential danger to public health, because they can carry pathogenic organisms and are possibly directly associated with the hospital cross infection problem. During a one-year period, collections were carried out, using non-toxic baits in a hospital of Luz, Minas Gerais State. The samples were distributed in 16 sites, being three outside and the others inside the hospital. Ants were found in 15 of the 16 sampled points. The most abundant genera were Brachymyrmex e Tapinoma, recorded inside and outside the hospital. The Camponotus genus was present as well, and generally collected where food was available (such as kitchen, rooms, refectory and garbage packing places) and structural failings on walls. Wasmannia, Pheidole, Linepithema, Monomorium, Dorymyrmex, Solenopsis and Paratrechina were also collected, totaling ten genera. Our results indicate a possible implication of the precarious condition in the hospital structure and the importance of cleaning in these environments.


Fonseca A.L.,University Estadual Of Minas Gerais | Silva R.A.,University Estadual Of Minas Gerais | Fux B.,Federal University of Espirito Santo | Madureira A.P.,Federal University of Säo João del Rei | And 2 more authors.
Revista da Sociedade Brasileira de Medicina Tropical | Year: 2012

Introduction: The aim of the present study was to analyze the exposure to risk factors for toxoplasmosis disease and the level of knowledge in pregnant women who were treated by the Public Health Care System (SUS) from October 2007 to September 2008 in Divinópolis City, Brazil. Methods: We analyzed 2,136 prenatal exams of pregnant women that were treated from October 2007 to September 2008. Results: Out of the 2,136 pregnant women evaluated, 200 answered a quantitative questionnaire; 49.5% were seropositive for immunoglobulin (Ig) G and 3.6% for IgM. Comparative analysis of congenital toxoplasmosis cases were evaluated in 11 regions and showed an irregular distribution (p < 0.01). This difference was also observed among the pregnant women observed in each location. The results from the questionnaire show that 93% of the pregnant women had no knowledge about toxoplasmosis, and 24% presented with positive serology, but no clinical manifestation. Analysis for pregnant IgG-positive women and the presence of pets showed a statistically significant correlation (p < 0.05), suggesting that the transmission of this disease might occur in the domestic environment. Conclusions: We suggest the implementation of a triage program for pregnant women and health education to encourage their use of SUS services.


Villanova J.C.O.,Mogi Das Cruzes University | Lima T.H.,Federal University of Minas Gerais | Patricio P.S.,Federal University of Minas Gerais | Pereira F.V.,Federal University of Minas Gerais | Ayres E.,University Estadual Of Minas Gerais
Quimica Nova | Year: 2012

One of the difficulties reported for the suspension polymerization is control the size and granulometry of beads. The purpose of this work was to evaluate the use of cellulose nanowhiskers and mesoporous silica as stabilizers to reduce the size and the particle distribution. To monitor polymerization process was used FTIR-ATR spectroscopy. The morphology was analyzed by scanning electron microscopy. The particle size distribution was characterised using a CILAS granulometer. Thermal stability was studied by thermogravimetric analysis. The results indicated that cellulose nanowhiskers may provide stabilization and increase the thermal stability of the beads in contrast to mesoporous silica.


Martins L.,Federal University of Minas Gerais | Guimaraes R.E.S.,Federal University of Minas Gerais | Becker H.M.G.,Federal University of Minas Gerais | Bedran M.B.,University Hospital | And 2 more authors.
Jornal de Pediatria | Year: 2011

Objective: To assess the prevalence of middle ear alterations in cystic fibrosis (CF) patients. Methods: In this descriptive study, 120 CF patients aged 5 months to 18 years were assessed by clinical history, otoscopy, and tympanometry. Data on P. aeruginosa colonization and parenteral and/or inhaled aminoglycoside use were also collected from medical charts. Results: Clinical history revealed absence of previous otitis media in 57% of patients. Tympanic membranes were normal in 94% of patients who underwent otoscopic evaluation; chronic otitis media was suggested in about 1% of the cases, otitis media with effusion (OME) in 2%, and Eustachian tube dysfunction in 3%. As for tympanometry, 91% of patients who underwent the exam showed normal results, OME was suggested in 2% of the cases, and Eustachian tube dysfunction in 7%. Conclusion: There was a low prevalence rate of middle ear alterations in our series of CF patients. The use of aminoglycosides and colonization by P. aeruginosa did not influence the prevalence of middle ear alterations. Our results suggest that a detailed clinical history and a routine otoscopy evaluation may confirm or rule out most middle ear alterations in CF patients. Copyright © 2011 by Sociedade Brasileira de Pediatria.


PubMed | University Estadual Of Minas Gerais and Federal University of Minas Gerais
Type: | Journal: The Journal of sports medicine and physical fitness | Year: 2017

The aim of this study was to verify the agreement of urine, body mass variations and plasma parameters to determine the hydration status of 14 male runners (29 4 years and 54.3 5.5 mLO2.kg-1.min-1) in an official 21.1 km road race.The mean dry-bulb temperature and air relative humidity during the road race were 25.1 2.1 C and 54.7 2.2%, respectively. The volume of water ingested by the runners was monitored using marked volumetric plastic bottles provided at the hydration stations located at 0, 2.5, 5.0, 7.5, 10.5, 14.0, 16.0 and 18.5 km from the starting line. Hydration status was assessed using urine specific gravity (USG), urine osmolality (UOSM) and plasma osmolality (POSM). Furthermore, body mass variation (BM) was assessed by comparing body mass (BM) immediately prior and after the race. Total sweat was estimated by BM, added water volume ingested and deducted blood volume collected. The sweat rate was calculated through total sweat and total exercise time.The mean water intake was 0.82 0.40 L, and the mean sweat rate and total sweating were 1440.11 182.13 mL.h-1 and 2.67 0.23 L. After the race, the BM reduced by 1.7 0.4 kg. The BM was - 2.41 0.47%, and the plasma volume variation was - 9.79 4.6 % between pre and post-running measurements. Despite the POSM increased post-race compared to pre-race, the UOSM and USG did not change. No significant correlations were found between POSM variation with UOSM variation (r = -0.08; p = 0.71), USG variation (r = -0.11; p = 0.78) or BM (r = 0.09; p = 0.77).In conclusion, this study shows that both BM and POSM indicated a hypohydration state after exercise even though the BM did not correlate significantly with POSM. These results demonstrate that BM is a practical method and can be sufficiently sensitive to evaluate the hydration state, but it should be utilized with caution.


Panarelli E.A.,University Estadual Of Minas Gerais | Guntzel A.M.,State University of Mato Grosso do Sul | Borges C.N.,University Estadual Of Minas Gerais
Brazilian Journal of Biology | Year: 2013

This study examined the cladoceran assemblages in three oxbow lakes of the Taquari River floodplain, near the transition between the plateau and the plain. We sought to answer the following questions: does the Taquari River function as a geographical barrier or dispersal corridor for Cladocera? Can different degrees of connection induce different structures in the assemblages in each lake? Cladocerans and limnological variables were sampled every other month for one year. Forty-one species were recorded, four of which were common to all the lakes. Our results indicated that the different degrees of connection between the river and the oxbow lakes favoured environmental heterogeneity and diversification in the cladoceran assemblages. The greatest dissimilarity between the two lakes connected with the river indicates that in this case the river functions better as a barrier than a dispersal corridor.


Corgosinho P.H.C.,Bairro Universitario | Corgosinho P.H.C.,University Estadual Of Minas Gerais
Journal of Natural History | Year: 2012

A new genus of Nannopodidae is described. Talpacoxa brandini gen. et sp. nov. is a typical sand-dwelling species with modified burrowing first legs. The new genus can be diagnosed by leg 1 transformed into a burrowing structure; coxa hypertrophied, longer than the exopod and the endopod, with a well-developed crista, downwardly extended, with a bifid tip; exopod one-segmented, strong, rectangular, ornamented with various cuneiform spinules; endopod two-segmented, second endopodal segment with two distal elements; intercoxal plate well developed, longer than the exopod and the endopod. Leg two to leg four reduced, with two-segmented exopod and one-segmented endopod; limbs laterally displaced with no trace of intercoxal plate. Leg five exopod one-segmented; intercoxal plate reduced. The new genus is tentatively included within Nannopodidae because of some putative synapomorphies shared with the genera Rosacletodes, Huntemannia, Laophontisochra and Acuticoxa. © 2012 Copyright Taylor and Francis Group, LLC.


de Nobile F.O.,Centro Universitario da Fundacao Educacional | Galbiatti J.A.,São Paulo State University | Muraishi R.I.,Fundacao Educacional | Araujo J.R.,University Estadual Of Minas Gerais
Engenharia Agricola | Year: 2011

The agricultural use of organic and industrial residues is an alternative of exploitation with fertilization and source of organic matter to the soil. In this direction, the objective of this research was to evaluate the use of the urban solid waste and biofertilizer as nutrient source, and residue of the bauxite processing as agricultural liming materials of the soil for sugar cane (cane plant) and culture yields, irrigated with potable water and wastewater. For in such an experiment in vase was lead, under Alfisol soil, cultivated with the variety RB855536. It had been evaluated biometric variable of the plant such as: plant height, diameter of stem, tillering, leaf number, dry matter of the root and dry matter of the aerial part. The data showed that the quality of the irrigation water, potable and wastewater, did not influence the evaluated parameters. The application of urban solid waste and biofertilizer had consisted in an efficient source of nutrients for sugar cane plants, but is necessary to apply additional fertilizer for the attainment of stem production similar to the treatment with conventional mineral fertilization. Now the residue of the bauxite processing revealed efficient in the correction of the acidity presenting similar physical parameters to the treatment with mineral fertilization and lime, with exception of the dry matter of the root.


PubMed | University Estadual Of Minas Gerais
Type: Journal Article | Journal: Revista da Sociedade Brasileira de Medicina Tropical | Year: 2012

The aim of the present study was to analyze the exposure to risk factors for toxoplasmosis disease and the level of knowledge in pregnant women who were treated by the Public Health Care System (SUS) from October 2007 to September 2008 in Divinpolis City, Brazil.We analyzed 2,136 prenatal exams of pregnant women that were treated from October 2007 to September 2008.Out of the 2,136 pregnant women evaluated, 200 answered a quantitative questionnaire; 49.5% were seropositive for immunoglobulin (Ig) G and 3.6% for IgM. Comparative analysis of congenital toxoplasmosis cases were evaluated in 11 regions and showed an irregular distribution (p < 0.01). This difference was also observed among the pregnant women observed in each location. The results from the questionnaire show that 93% of the pregnant women had no knowledge about toxoplasmosis, and 24% presented with positive serology, but no clinical manifestation. Analysis for pregnant IgG-positive women and the presence of pets showed a statistically significant correlation (p < 0.05), suggesting that the transmission of this disease might occur in the domestic environment.We suggest the implementation of a triage program for pregnant women and health education to encourage their use of SUS services.

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