Castro I.B.,Grande Rio University |
Rocha-Barreira C.A.,Labomar Inc. |
Fernandez M.A.,University Estadual Do Rio Of Janeiro Uerj |
Marine Biology Research | Year: 2012
A bioassay to study differential specific responses in imposex development due to marine organotin pollution was done by transplanting specimens of the gastropods Stramonita haemastoma and Stramonita rustica from an imposex-free area to a marina with high marine traffic inside a ship repair yard, a place where local populations of S. haemastoma were known to show high indices of imposex. Three hundred sexually mature, imposex-free specimens of each species were kept in cages for 120 days, and samples of 30 individuals were periodically analysed for imposex development. Shell length, penis length and vas deferens development were recorded and imposex development indices (% imposex, RPLI and VDSI) were calculated. Our results indicated that imposex induction in S. haemastoma is faster and more sensitive than in S. rustica. Imposex incidence in S. haemastoma could be a useful tool for monitoring marine pollution by organotin compounds in harbours along the Brazilian coast. © 2012 Copyright Taylor and Francis Group, LLC.
Fortes M.T.,Escola Nacional de Saude Publica ENSP |
de Mattos R.A.,University Estadual Do Rio Of Janeiro Uerj |
Revista da Associacao Medica Brasileira | Year: 2011
This article analyzes the dynamics and changes in the accreditation process in three different places - France, UK and Cataluña (Spain) - based on documents about their health systems organizations, funding sources and regulations. The objective was to find out about the relevant aspects of the strategies of these countries' institutions that adapted accreditation to national circumstances in the healthcare policy arena. Although there are similarities in the basic approaches and standards used, there are different models of accreditation. Setting standards raises the question of who should define them and how they should be monitored; accreditation's methodology cannot be seen only as a voluntary process for assessing quality in healthcare or perceived as tool for certification and regulation. Interests in accreditation can be driven by a number of different forces, which depend upon the model adopted. Therefore, it can only be understood in the policy arena of each country.
Pilling S.,University of Paraíba Valley |
Baptista L.,University Estadual Do Rio Of Janeiro Uerj |
Boechat-Roberty H.M.,Federal University of Rio de Janeiro |
Andrade D.P.P.,University of Paraíba Valley
Astrobiology | Year: 2011
Despite the extensive search for glycine (NH 2CH 2COOH) and other amino acids in molecular clouds associated with star-forming regions, only upper limits have been derived from radio observations. Nevertheless, two of glycine's precursors, formic acid and acetic acid, have been abundantly detected. Although both precursors may lead to glycine formation, the efficiency of reaction depends on their abundance and survival in the presence of a radiation field. These facts could promote some favoritism in the reaction pathways in the gas phase and solid phase (ice). Glycine and these two simplest carboxylic acids are found in many meteorites. Recently, glycine was also observed in cometary samples returned by the Stardust space probe. The goal of this work was to perform theoretical calculations for several interstellar reactions involving the simplest carboxylic acids as well as the carboxyl radical (COOH) in both gas and solid (ice) phase to understand which reactions could be the most favorable to produce glycine in interstellar regions fully illuminated by soft X-rays and UV, such as star-forming regions. The calculations were performed at four different levels for the gas phase (B3LYP/6-31G*, B3LYP/6-31++G**, MP2/6-31G*, and MP2/6-31++G**) and at MP2/6-31++G** level for the solid phase (ice). The current two-body reactions (thermochemical calculation) were combined with previous experimental data on the photodissociation of carboxylic acids to promote possible favoritism for glycine formation in the scenario involving formic and acetic acid in both gas and solid phase. Given that formic acid is destroyed more in the gas phase by soft X-rays than acetic acid is, we suggest that in the gas phase the most favorable reactions are acetic acid with NH or NH 2OH. Another possible reaction involves NH 2CH 2 and COOH, one of the most-produced radicals from the photodissociation of acetic acid. In the solid phase, we suggest that the reactions of formic acid with NH 2CH or NH 2CH 2OH are the most favorable from the thermochemical point of view. Key Words: Interstellar molecules-Interstellar environments-Abiotic organic synthesis-Extraterrestrial organic compounds-Prebiotic chemistry. © 2011, Mary Ann Liebert, Inc.
Garcia-Pinto A.B.,University Estadual Do Rio Of Janeiro Uerj |
de Matos V.S.,University Estadual Do Rio Of Janeiro Uerj |
Rocha V.,University Estadual Do Rio Of Janeiro Uerj |
Moraes-Teixeira J.,University Estadual Do Rio Of Janeiro Uerj |
Carvalho J.J.,University Estadual Do Rio Of Janeiro Uerj
Clinics | Year: 2011
INTRODUCTION AND OBJECTIVE: Kidney disorders can cause essential hypertension, which can subsequently cause renal disease. High blood pressure is also common among those with chronic kidney disease; moreover, it is a wellknown risk factor for a more rapid progression to kidney failure. Because hypertension and kidney function are closely linked, the present study aimed to observe the beneficial effects of low-intensity physical activity on structural and ultrastructural renal morphology and blood pressure in normotensive and spontaneously hypertensive rats. METHOD: Male Wistar-Kyoto rats and spontaneously hypertensive rats were randomly allocated into four groups: sedentary or exercised Wistar-Kyoto and sedentary or exercised spontaneously hypertensive rats. The exercise lasted 20 weeks and consisted of treadmill training for 1 hour/day, 5 days/week. RESULTS: The exercised, spontaneously hypertensive rats showed a significant blood pressure reduction of 26%. The body masses of the Wistar-Kyoto and spontaneously hypertensive strains were significantly different. There were improvements in some of the renal structures of the animals treated with physical activity: (i) the interdigitations of the proximal and distal convoluted tubules; (ii) the basal membrane of the proximal and distal convoluted tubules; and (iii) in the basal membrane, slit diaphragm and pedicels of the glomerular filtration barrier. The spontaneously hypertensive rats also showed a decreased expression of connexin-43. CONCLUSION: Physical exercise could be a therapeutic tool for improving kidney ultrastructure and, consequently, renal function in hypertensive individuals. © 2011 CLINICS.
Ayres A.R.G.,University Estadual Do Rio Of Janeiro Uerj |
Azevedo e Silva G.,State University of Rio de Janeiro
Revista de Saude Publica | Year: 2010
Objective: To assess the prevalence of human papillomavirus (HPV) infection in women in Brazil. Methods: A systematic literature review was conducted with an active search in PubMed and Virtual Health Library databases using the terms "human papillomavirus,""HPV,""prevalence," and "Brazil". Of 155 articles retrieved, 82 were selected after reading their title and abstract. After a thorough examination, 14 articles were included in the study. Results: The 14 articles selected were published between 1989 and 2008 and comprised studies from four Brazilian macroregions (Southeast - 43%; South - 21.4%; Northeast - 21.4%; and North - 7.1%). Nine were crosssectional studies. Eight articles used polymerase chain reaction and seven used hybrid capture for HPV detection. The study samples ranged from 49 to 2,329 women. The overall prevalence of HPV cervical infection was between 13.7% and 54.3%; and women with cytologically normal results had 10% to 24.5% prevalence of HPV cervical infection. Four articles described the most common HPV types. Conclusions: The cytology techniques available use different classifications leading to different HPV prevalence estimates. However, considering the studies individually according to the detection technique used, the HPV prevalence has increased. HPV16 was the most prevalent type among women, regardless of the cytology result. The concentration of studies in the Southeast region, especially in metropolitan regions, evidences that further investigations are needed to improve information coverage of Brazilian women.
Cunha H.,Pontifical Catholic University of Rio de Janeiro |
Do Prado Leite J.C.S.,Pontifical Catholic University of Rio de Janeiro |
Duboc L.,University Estadual Do Rio Of Janeiro Uerj |
Werneck V.,University Estadual Do Rio Of Janeiro Uerj
2013 3rd International Workshop on Requirements Patterns, RePa 2013 - Proceedings | Year: 2013
Patterns are an invaluable tool for capturing and reusing Non-Functional Requirements (NFR) knowledge. Their construction, however, requires one to pay close attention to the semantics of its elements. This paper reports two important insights realized when developing a collection of Transparency patterns; they concern the semantics of the HELP contribution link and of the correlation link between NFR softgoals. The drawbacks of using these interdependency types are discussed and solutions are presented. The discussion is relevant to anyone attempting to develop precise catalogs for capturing NFR knowledge. © 2013 IEEE.
Carranza-Tamayo C.O.,University of Brasilia |
Werneck G.L.,University Estadual Do Rio Of Janeiro Uerj |
Romero G.A.S.,University of Brasilia
Brazilian Journal of Infectious Diseases | Year: 2016
A population survey was conducted to explore the prevalence and factors associated with Leishmania infection in the Fercal region of the Federal District. The Fercal region is a group of neighborhoods in Brasília in which the first cases of visceral leishmaniasis were described. Leishmania infection was established by a positive leishmanin test. Although other tests were performed in the study (an immunochromatographic assay (Kalazar detect®) and a molecular assay), only the leishmanin skin test provided sufficient results for the measurement of the disease prevalence. Data on the epidemiological, clinical and environmental characteristics of individuals were collected along with the diagnostic tests. After sampling and enrollment, seven hundred people from 2 to 14 years of age were included in the study. The prevalence of Leishmania infection was 33.28% (95% CI 29.87-36.84). The factors associated with Leishmania infection according to the multivariate analysis were age of more than seven years and the presence of opossums near the home. Age is a known factor associated with Leishmania infection; however, the presence of wild animals, as described, is an understudied factor. The presence of opossums, which are known reservoirs of Leishmania, in peri-urban areas could be the link between the rural and urban occurrence of visceral leishmaniasis in the outskirts of largest Brazilian cities, as suggested by previous studies. © 2016 Elsevier Editora Ltda.
Fantuzzi F.,Federal University of Rio de Janeiro |
Baptista L.,University Estadual Do Rio Of Janeiro Uerj |
Rocha A.B.,Federal University of Rio de Janeiro |
Boechat-Roberty H.M.,Federal University of Rio de Janeiro
International Journal of Quantum Chemistry | Year: 2012
The structure and stability of several C2H4O 2 +· and C2H4O 2 2+ isomers were studied by quantum chemical methods in an attempt to elucidate their most stable molecular arrangements and infer their contribution to the ion chemistry of astrophysical environments. The geometry optimizations were performed at B3LYP/6-311G** and MP2/6-311G** level. Single-point calculations at equilibrium geometries were performed at left eigenstate completely renormalized coupled cluster method, CR-CCL(2,3). Ninety minimum structures for the ions at the MP2 level were found: 38 related to C2H4O2 +·, 33 to C2H4O2 2+, and 19 to ion-neutral complexes. The more stable C 2H4O2 +· isomers have enolic structures, in agreement with the McLafferty rearrangement mechanism of straight chain aliphatic acids. In contrast, the most stable C2H 4O2 2+ isomer has an acyclic OCCO nonplanar linear chain structure, with terminal +OH2 and Ci-O + linkages. In addition, acetic acid and methyl formate analogue structures were found only for the monopositive ion, with higher energies though. Both global minima are significantly different from the more stable neutral isomers and, therefore, could not be found in a geometry optimization procedure starting from the neutral structures. Dissociative recombination reaction pathways of C2H4O2 +· and its application to the formation of astrophysical neutral molecules are also discussed. © 2012 Wiley Periodicals, Inc.
Vidal E.I.O.,São Paulo State University |
Moreira-Filho D.C.,University of Campinas |
Pinheiro R.S.,Federal University of Rio de Janeiro |
Souza R.C.,Health science Center |
And 5 more authors.
Osteoporosis International | Year: 2012
Summary: The relationship between surgical timing and hip fracture mortality is unknown in the context of developing countries where large delays to surgery are common. We observed that delay from fracture to hospital admission is associated with decreased survival after a hip fracture. Introduction: To examine the relationship between the time interval from fracture to surgery as well as its subcomponents (time from fracture to hospital admission and time from admission to surgery) and hip fracture survival. Methods: The medical records of all patients aged 60 years and older admitted to a public university hospital in the city of Rio de Janeiro with a primary diagnosis of hip fracture between 1995 and 2000 were reviewed. Survival to hospital discharge and at 1 year were examined. Results: Among 343 patients included in the study, there were 18 (5.3%) in-hospital deaths, and 297 (86.6%) patients remained alive 1 year after surgery. Very long delays from the time of fracture to hospital admission (mean 3 days) and from hospital admission to surgery (mean 13 days) were identified. Increased time from fracture to hospital admission was associated with reduced survival to hospital discharge (hazard ratio [HR] 1.09, 95% CI 1.03-1.15, p00.005) and reduced survival at 1 year after surgery (HR 1.07, 95% CI 1.03-1.10, p< 0.001). The interval of time from hospital admission to surgery was not associated with reduced survival to hospital discharge (HR 1.03, 95% CI 0.96-1.10, p00.379) or at 1 year after surgery (HR 1.03, 95% CI 0.99-1.07, p00.185). Conclusions: If the association estimated in our study is causal, our results provide evidence that some hip fracturerelated deaths could be prevented by improved patient access to appropriate and timely hospital care in the context of a developing country. © International Osteoporosis Foundation and National Osteoporosis Foundation 2012.
Prevalence of HPV infection among women covered by the Family Health Program in the Baixada Fluminense, Rio de Janeiro, Brazil [Prevalência de HPV em mulheres assistidas pela estratégia saúde da família na Baixa fluminense do Estado do Rio de Janeiro]
Girianelli V.R.,University Estadual Do Rio Of Janeiro Uerj |
Thuler L.C.S.,Rio de Janeiro State Federal University |
Silva G.A.,University Estadual Do Rio Of Janeiro Uerj
Revista Brasileira de Ginecologia e Obstetricia | Year: 2010
PURPOSE: to evaluate the prevalence of HPV infection and associated factors among women living in the "Baixada Fluminense", state of Rio de Janeiro, Brazil. METHODS: a cross-sectional study conducted on a sample of 2,056 women aged 25-59 years covered by the Family Health Program in the municipalities of Duque de Caxias and Nova Iguaçu, state of Rio de Janeiro, southeastern Brazil. All women were submitted to the Papanicolaou and HPV detection tests in a single session by second-generation hybrid capture from December 2001 to July 2002. The prevalence of HPV was stratified by age, place of residence, schooling, smoking habit, and sexual and reproductive history. The prevalence rates associated with the studied variables were calculated by Multivariate Poisson regression. RESULTS: the prevalence of HPV was 12.3% and 5.0% for high-risk and low-risk HPV types, respectively. A reduction in high-risk HPV prevalence was observed with aging, with an increase in the 55-59 year age range. After adjusting for age, schooling, smoking, early sexual initiation and parity, high-risk HPV infection was associated with not living with a partner (1.4; 95%CI=1.1-1.8) and having more than one sexual partner (an increase of 1.4%; 95%CI=1.1-1.6, for each lifetime sexual partner). CONCLUSIONS: the prevalence of HPV was lower than that reported in other Brazilians studies, most likely because our sample was population-based. HPV infection was associated only with factors related to sexual behavior, but the potential association between HPV infection and smoking still needs to be better understood. Further studies are needed to explore these issues, as well as postmenopausal increased infection rates, and to identify the most prevalent HPV types in the Brazilian population.