University do Grande

Santo André, Brazil

University do Grande

Santo André, Brazil
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Lino P.B.,University do Grande | Correa C.F.,Catholic University of Santos | Archondo M.E.D.L.,University do Grande | Dellova D.C.A.L.,University of Sao Paulo
Brazilian Journal of Pharmacognosy | Year: 2011

Considering that oral preparations made with peel green bananas (e.g. flour and extracts) demonstrated healing effects on mucous membranes and skin, this study evaluated the healing and the antimicrobial property of a topical preparation based on extract of Musa sapientum L., Musaceae, (apple banana) in surgically induced wounds in the skin of male Wistar rats, 100 g. The extract was obtained by decoction, the presence of tannins was detected by phytochemical screening and 10% of the extract was incorporated into the carbopol gel (CMS gel). The processes of healing and bacterial isolation were evaluated in the following experimental groups: control (no treatment), treatment with placebo or with the CMS gel. The healing of surgical wounds treated with the CMS gel was faster when compared with the control and placebo groups and the treatment with CMS gel also inhibited the growth of pyogenic bacteria and enterobacteria in the wounds. The results indicate that the extract of Musa sapientum epicarp has healing and antimicrobial properties (in vivo), probably, due to tannins.

Gimenez B.G.,Centro Universitario Sao Camilo | Santos M.S.,Centro Universitario Sao Camilo | Ferrarini M.,University do Grande | Dos Santos Fernandes J.P.,Centro Universitario Sao Camilo | Dos Santos Fernandes J.P.,University do Grande
Pharmazie | Year: 2010

The current drug research techniques, combinatorial synthesis and high throughput screening, enabled the obtaining and pre-evaluation of thousands of compounds in short time. In order to chose the best hits to become leads, observation of drug-likeness tries to optimize this selection. Probably, the most widely used filter is Lipinski's Rule-of-five, which proposes that molecules with poor permeation and oral absorption have molecular weight > 500, Clog P> 5, hydrogen-bond donor > 5 and hydrogen-bond acceptor > 10. In order to evaluate the Rule-of-five, the top pharmaceutical products in 2007 were analyzed. Among 60 drugs, 7 (atorvastatin, montelukast, docetaxel, telmisartan, tacrolimus, leuprolide and olmesartan) did not fit the rule, and 5 failed only one of the threshold values. It was possible to conclude that the rule is very useful to select better compounds in chemolibraries, but it must be used carefully and with criteria, to avoid a possible exclusion of promising compounds.

Fukuda T.Y.,Setor de Fisioterapia | Fukuda T.Y.,Federal University of São Paulo | Jesus J.F.,Setor de Fisioterapia | Santos M.G.,Setor de Fisioterapia | And 4 more authors.
Revista Brasileira de Fisioterapia | Year: 2010

Background: Despite the increase in the use of low-level laser therapy (LLLT), there is still a lack of consensus in the literature regarding how often the equipment must be calibrated. Objective: To evaluate the real average power of LLLT devices in the Greater São Paulo area. Methods: For the evaluation, a LaserCheck power meter designed to calibrate continuous equipment was used. The power meter was programmed with data related to the laser's wavelength to gauge the real average power being emitted. The LLLT devices were evaluated in two ways: fi rst with the device cooled down and then with the device warmed up for 10 minutes. For each condition, three tests were performed. The laser probe was aligned with the power meter, which provided the real average power being emitted by the LLLT device. All of the data and information related to the laser application were collected with the use of a questionnaire fi lled in by the supervising therapists. Results: The 60 devices evaluated showed defi cit in real average power in the cooled-down and warmedup condition. The statistical analysis (ANOVA) showed a signifi cant decrease (p<0.05) in the real average power measured in relation to the manufacturer's average power. On average, the most common dose in the clinics was 4 J/cm2, and the most desired effects were healing and anti-infl ammatory effects. According to the World Association for Laser Therapy (WALT), 1 to 4 J of fi nal energy are necessary to achieve these effects, however only one device was able to reach the recommended therapeutic window. Conclusion: The LLLT devices showed a defi cit in real average power that emphasized a lack of order in the application of this tool. The present study also showed the need for periodical calibration of LLLT equipment and a better technical knowledge of the therapists involved.

Queiroz A.C.,University Camilo Castelo Branco | Ferrarini M.,University do Grande | Fernandes J.P.S.,University Camilo Castelo Branco | Fernandes J.P.S.,University do Grande
Latin American Journal of Pharmacy | Year: 2010

Drug interactions occur with the indiscriminate and excessive use of drugs. However, this could result in efficient tnerapy or adverse reactions with ditterent degrees of severity. This work aimed to acquire drug interactions data, obtained through medical prescriptions. 50 medical prescriptions dispensed in the Ferraz de Vasconcelos city has been analyzed. Drug interactions were found in 70% of the prescriptions. The interactions were classified according its risk index, being 45.71% of the interactions for index B, 51.43% index C, 2.86% index D. Interactions with index X were not found. It was possible to conclude the majority of the observed interactions need therapy control, and pharmaceutical care is one of the tools to avoid these events.

Ferreira A.A.A.,University do Grande | Prates E.C.,Methodist University of Sao Paulo | Fernandes J.P.S.,University do Grande | Ferrarini M.,University do Grande
Revista de Ciencias Farmaceuticas Basica e Aplicada | Year: 2011

In order to assess the uniformity of the dose of active ingredient in the halves of tablets subjected to splitting, the hardness, friability, weight variability and uniformity of content were studied in four samples of 40 mg tablets of furosemide obtained on the Brazilian market, both whole and split into two parts. All the tablets complied with the official specifications before splitting, but, after this procedure, the drug content in the halves showed excessive variation, indicating that this procedure is inadvisable.

Fukuda T.Y.,Federal University of São Paulo | Tanji M.M.,University of Sao Paulo | Tanji M.M.,University do Grande | Jesus J.F.,University do Grande | And 3 more authors.
Lasers in Surgery and Medicine | Year: 2010

Background and Objective: The results of low-level infrared laser (LLL) systemic action on inflammatory modulation process, specifically diminishing proinflammatory and producing anti-inflammatory cytokines are extremely controversial in the literature. More studies are necessary to clarify the biomodulation process. The main objective was to investigate the effect of a single session of an AsGaAl laser on spleen cells interleukin-6 (IL-6) and tumor necrosis factor - alpha (TNF-α) release, in vivo, in mice. Study Design/Materials and Methods: In a pilot study, 18 isogenic mice were distributed in three groups: control (no surgical procedure, n = 6), sham (surgical procedure with three standard cutaneous incisions, followed by abdominal muscle incision followed by suture, n = 6) and LLL (same procedure followed by a single LLL exposure 12 hours after the procedure, n = 6). The animals in the LLL group received a single infrared continuous laser session (780 nm wavelength, power of 20 mW, energy density of 10 J/cm 2) on three points (20 seconds per point), and final energy of 0.4 J. All animals of the sham and LLL groups were sacrificed 36 hours after surgical procedure; the spleen mononuclear cells were isolated and cultivated for 48 hours. The IL-6 and TNF-α were measured by the ELISA method. Results: IL-6 and TNF-α concentrations released by the mononuclear cells showed significant differences between the control and sham group (P<0.07). However, there were no differences between the control and LLL group and between the sham and LLL groups (P>0.07). Conclusion: The single session of infrared LLL showed a tendency of decreasing the IL-6 and TNF-α release by mononuclear spleen cells in mice after application, although there was not a significant difference between the sham and LLL group. Conclusions regarding effectiveness of a single session procedure cannot be made due to the low statistical power of this pilot study. © 2010 Wiley-Liss, Inc.

Schlesinger D.,University of Sao Paulo | Schlesinger D.,Instituto Israelita Of Ensino E Pesquisa Albert Einstein | Grinberg L.T.,University of Sao Paulo | Grinberg L.T.,Memory and Aging Center | And 15 more authors.
Molecular Psychiatry | Year: 2013

Previous studies in dementia epidemiology have reported higher Alzheimer's disease rates in African-Americans when compared with White Americans. To determine whether genetically determined African ancestry is associated with neuropathological changes commonly associated with dementia, we analyzed a population-based brain bank in the highly admixed city of São Paulo, Brazil. African ancestry was estimated through the use of previously described ancestry-informative markers. Risk of presence of neuritic plaques, neurofibrillary tangles, small vessel disease, brain infarcts and Lewy bodies in subjects with significant African ancestry versus those without was determined. Results were adjusted for multiple environmental risk factors, demographic variables and apolipoprotein E genotype. African ancestry was inversely correlated with neuritic plaques (P0.03). Subjects with significant African ancestry (n112, 55.4%) showed lower prevalence of neuritic plaques in the univariate analysis (odds ratio (OR) 0.72, 95% confidence interval (CI) 0.55-0.95, P0.01) and when adjusted for age, sex, APOE genotype and environmental risk factors (OR 0.43, 95% CI 0.21-0.89, P0.02). There were no significant differences for the presence of other neuropathological alterations. We show for the first time, using genetically determined ancestry, that African ancestry may be highly protective of Alzheimer's disease neuropathology, functioning through either genetic variants or unknown environmental factors. Epidemiological studies correlating African-American race/ethnicity with increased Alzheimer's disease rates should not be interpreted as surrogates of genetic ancestry or considered to represent African-derived populations from the developing nations such as Brazil. © 2013 Macmillan Publishers Limited.

Jaimes R.F.V.V.,University do Grande | Afonso M.L.C.d.A.,Technological and Nuclear Institute of Portugal | Rogero S.O.,Brazilian Nuclear Energy Research Institute (IPEN) | Agostinho S.M.L.,University of Sao Paulo | Barbosa C.A.,Villares Metals SA
Materials Letters | Year: 2010

Nickel, a component of stainless steels (SS) applied in orthopedic implants may cause allergic processes in human tissues. P558 nickel free SS was studied to verify its viability as a substitute for stainless steel containing nickel. Its performance is compared to ISO 5832-9 and F138 most used nowadays grades in implants fabrications, in minimum essential medium, MEM, at 37 °C. Potentiodynamic polarization curves, electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and "in vitro" cytotoxicity were used as techniques. From the electrochemical point of view P558 SS is comparable to ISO 5832-9 SS in MEM. It remains passivated until the transpassivation potential, above which generalized corrosion occurs. F138 presents pitting corrosion at 370 mV/SCE. The cytotoxicity results showed that P558, ISO 5832-9 and F138 do not present cytotoxic character. Therefore, these results suggest that P558 SS can be applied in orthopedic implants. © 2010 Elsevier B.V. All rights reserved.

PubMed | University do Grande and University of Sao Paulo
Type: Journal Article | Journal: Revista latino-americana de enfermagem | Year: 2014

analyze contextual aspects of the beginning of tobacco use in different social groups, from everyday representations about the act of smoking.five focus groups were conducted to promote discussion about the context of beginning of tobacco use, with groups of people who represented different patterns of social reproduction. The data analysis was based on the theory of social representations, which contextualizes how each group presents the tobacco consumption.the contexts of the beginning of tobacco use were diverse, according to patterns of social reproduction; there were common representations to all groups, but there were also unique representations of each social group. Tobacco is represented as indispensable for groups in unstable social reproduction situations, and as an instrument of pleasure and stress relief for those who can access other material assets.the study contributed to exposing the concepts on tobacco consumption that are socially disseminated, which can serve as an instrument to planning programs and health actions.

This qualitative study aimed to identify difficulties experienced by Community Health Agents (CHA) in the course of daily practice of care. Data were collected from semi-structured interviews with twelve CHA from four Basic Health Units in a city of the state of São Paulo, Brazil. From an analysis of the speech of subjects, we found that the deficiency of health services, the workload of the nurses responsible for the team and the service rejection by users make it difficult to implement the health actions. This research emphasizes the limitations expressed by the health agents, and points towards the necessity of an evolving discussion of this theme, seeking strategies that enable the consolidation of community health principles.

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