Clermont-Ferrand, France
Clermont-Ferrand, France

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Harris H.,Karolinska Institutet | Harris H.,Brigham And Womens Hospital | Harris H.,Fred Hutchinson Cancer Research Center | Wolk A.,Karolinska Institutet | And 4 more authors.
International Journal of Molecular Epidemiology and Genetics | Year: 2016

Vascular endothelial growth factor (VEGF) is a signalling protein that has been established as a contributor to tumor angiogenesis, and expression of VEGF and its soluble receptors (sVEGFR2 and sVEGFR3) have been demonstrated in breast cancer cells. However, no prospective studies have examined the association between prediagnostic sVEGFR levels and breast cancer risk. We conducted a prospective case-control study nested within the Swedish Mammography Cohort examining the association between sVEGFR2 and 3 levels and breast cancer risk. The analysis included 69 incident breast cancer cases diagnosed after blood collection and 719 controls. Logistic regression models were used to calculate odds ratios and 95% confidence intervals. After adjustment for breast cancer risk factors, sVEGFR2 levels were associated with breast cancer risk (OR=1.28; 95% CI=1.06-1.56 per 1000 ng/L increase in concentration) while sVEGFR3 levels were not related to such risk (OR=1.00; 95% CI=0.93-1.07). Our results suggest that sVEGFR2 levels may be positively associated with breast cancer risk, however future studies with larger case groups are necessary to confirm this association. © 2016, E-Century Publishing Corporation. All rights reserved.

Lebreton A.,Center Hospitalier University | Lebreton A.,University dAuvergne Clermont Ferrand | Lavigne G.,University of Nimes
Revue Francophone des Laboratoires | Year: 2012

At this day, the development of inhibitory alloantibodies against FVIII or FIX is the main iatrogenic complication of haemophilia A or B. These antibodies compromise the efficacity of the substitutive therapy. Consequences for the physicians are medical, psychologic, social and economic. The development of autoantibodies against coagulation factors in a subject without coagulopathy is a life-threatening event called acquired haemophilia. The detection of anti-factors antibodies and tools available for their physiopathologic study are on constant evolution. The aim of this review is to summarize the mode of interaction, the risk factors and the detection tools for these antibodies. New tools for fine epitope mapping are also exposed. These new technologies are essential for a better understanding of the physiopathologic mechanisms of such antibodies. © 2012 Published by Elsevier Masson SAS.

PubMed | Chevreau Consulting LLC Salt Lake City, University dAuvergne Clermont Ferrand, Stragen Services SAS Lyon and Stragen Pharma SA Geneva
Type: Journal Article | Journal: Food science & nutrition | Year: 2014

Occasional rhinitis symptoms caused by exposure to pollution or allergens is a growing concern. Based first on empirical observation of a lesser occurrence of allergies in quail farmers and then scientific works on ovomucoids properties, we developed a dietary supplement for the relief of such occasional rhinitis symptoms. The objective of the study was to determine whether one acute oral dose of the study product attenuates nasal provocation and other allergy-related symptoms after exposure to a standardized allergenic challenge as compared to placebo. Healthy subjects were recruited to participate in a randomized, double-blind, two-arm crossover, placebo-controlled, clinical trial. One acute dose of either the active study product (proprietary blend of quail egg) or placebo was given concomitantly to the standardized allergenic challenge. The primary endpoint was peak nasal inspiratory flow (PNIF) measurement and the secondary endpoints were subjects perceived feelings of well-being based on Visual Analog Scale (VAS) scores for allergy-related symptoms, as well as immunoglobulin E count. Forty-three healthy subjects were enrolled and evaluable in a per protocol analysis. A gradual increase in PNIF from nadir up to Time 120 reflected the normal, gradual recovery from nasal obstruction induced by allergenic challenge for both the active and the placebo groups. At all postchallenge time points, the active group had higher PNIF values compared to the placebo group, indicating that the active product was associated with fewer symptoms and reduced intensity of these symptoms. The active product resulted also in statistically significant improvements of most of the subjects perceived feelings of well-being based on VAS scores. No adverse events occurred during the study. In conclusion, the dietary supplement consisting of proprietary blend made of quail eggs provides fast and efficient relief of allergic rhinitis symptoms caused by the most common outdoor and indoor allergens, without adverse events.

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