Kone W.M.,University dAbobo Adjame |
Vargas M.,Swiss Tropical and Public Health Institute |
Vargas M.,University of Basel |
Keiser J.,Swiss Tropical and Public Health Institute |
Keiser J.,University of Basel
Parasitology Research | Year: 2012
Natural products play an important role in the discovery and development of new pharmaceuticals. In the present study, we assessed the anthelmintic properties of medicinal plants used in Cote d'Ivoire. Ethanolic extracts from 50 medicinal plants were tested in vitro against trematodes (Echinostoma caproni, Schistosoma mansoni) and nematodes (Ancylostoma ceylanicum, Heligmosomoides bakeri, Trichuris muris). Active extracts were evaluated for their cytotoxicity and followed up in vivo in mice harbouring adult S. mansoni, E. caproni and T. muris at single oral doses of 400 or 800 mg/kg. All extracts tested were active against at least one helminths species. Ten of the 65 extracts tested (15.4%) in vitro revealed activity against all helminths tested. Of 65 extracts tested in vitro at a concentration of 2 mg/ml, all caused death of schistosomula and 34.4% and 39.1% were lethal against adult S. mansoni and E. caproni 72 h post-incubation, respectively. The highest activity against A. ceylanicum in vitro was observed with Sclerocarya birrea at 2 mg/ml, which resulted in death of adult worms and inhibition of activity of third-stage larvae (L3). Of the extracts, 41.5% completely inhibited movement of H. bakeri L3 at minimal lethal concentration (MLC) values of 20-200 μg/ml 48 h post-incubation, and 15.4% paralysed adult H. bakeri at 200 μg/ml 72 h after incubation. Of the extracts, 19% resulted in death of adult T. muris at MLC values of 10-100 μg/ml. In vivo, none of the extracts tested revealed activity against E. caproni. Olax subscorpioidea achieved total and female worm burden reductions of 60% and 84%, respectively in S. mansoniinfected mice. Combretum mucronatum was the most active extracts in vivo against T. muris with a worm burden reduction of 85.3%. In conclusion, several of the medicinal plants used in Côte d'Ivoire are active against different helminths, hence might play a role in the treatment of helminthiases. Further studies are necessary to isolate the active components from these extracts. © Springer-Verlag 2011.
Hassam S.,CNRS Institute Materials Microelectronics nanosciences of Provence |
Boa D.,University dAbobo Adjame |
Rogez J.,CNRS Institute Materials Microelectronics nanosciences of Provence
Journal of Alloys and Compounds | Year: 2012
The molar enthalpies of mixing of the Au-In, In-Sb and Au-In-Sb alloys have been determined at 973 K using a Calvet high-temperature microcalorimeter by the drop method. Measurements in the ternary system Au-In-Sb were performed along four sections, x Au/x In = 1/3-1/1 and x In/x Sb = 1/1-3/1. The experimental calorimetric data and estimated values with a Redlich-Kister-Muggianu formulation are compared. © 2011 Elsevier B.V. All rights reserved.
Edi C.V.A.,Center Suisse Of Recherches Scientifiques En Cote Divoire |
Koudou B.G.,University dAbobo Adjame
Emerging Infectious Diseases | Year: 2012
control depends on mosquito susceptibility to insecticides. We tested Anopheles gambiae mosquitoes from Côte d'Ivoire for resistance and screened a subset for target site mutations. Mosquitoes were resistant to insecticides of all approved classes. Such complete resistance, which includes exceptionally strong phenotypes, presents a major threat to malaria control.
Ekou T.,French National Center for Scientific Research |
Ekou T.,University dAbobo Adjame |
Especel C.,French National Center for Scientific Research |
Royer S.,French National Center for Scientific Research
Catalysis Today | Year: 2011
Pt/x%Ti-SBA15 catalysts (x corresponding to the wt.% TiO 2 loading in the Ti-SiO 2 composite, in the range 25-60%) were synthesized by titanium precursor grafting in preformed mesoporous silica. Materials were characterized by several techniques, including elemental analysis, XRD, TEM and N 2-sorption isotherms to achieve structural and textural properties description. Different pore sizes were obtained for the SBA-15 materials, by using or not hexane as swelling agent. The catalytic performances of these original materials were evaluated for the selective hydrogenation of citral (α,β-unsaturated aldehyde), and compared with those of Pt/SBA and Pt/TiO 2 P25 reference catalysts. Pt/x%Ti-SBA15 catalysts present high specific surface, with TiO 2 nanoparticles and Pt 0 clusters located inside the hexagonal mesopore structure of silica. During citral hydrogenation, the selectivity towards unsaturated alcohols (nerol and geraniol) varies as a function of the support nature as follows: Pt/x%Ti-SBA15 > Pt/TiO 2 P25 Pt/SBA. The results are discussed in term of variable metal-support interaction (SMSI) generated by the partial reduction of TiO 2 species, this SMSI effect being reported more important over anatase TiO 2 nanoparticles dispersed inside the mesostructure than over large crystals encountered in the classical P25 support. © 2011 Elsevier B.V. All rights reserved.
Kone W.M.,University dAbobo Adjame
African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines | Year: 2012
Medicinal plants have been a source of succour in the control of many diseases in developing countries and anaemia is no exception. In this study, ethnomedical survey was carried out for recording medicinal plants used in Northern and South-Eastern Côte d'Ivoire against anaemia. Also iron content was determined for some of the recorded plants using phenanthroline method. Thirty (30) medicinal plants, covering 28 genera and 22 families were recorded. These plants were used to prepare 30 receipts for the treatment of anaemia and aggravating factors such as malaria and gastro-intestinal helminthes. Eleven (11) of these medicinal plants showed presence of iron in various quantities. The most promising were Tectona grandis, Amaranthus spinosus and Stylosanthes erecta which contained the highest iron contents viz; 266.6, 236.6 and 206.6 mg/100 g respectively. They were followed by Hoslundia opposita, Imperata cylindrica, Cajanus cajan, Thalia geniculata and Milicia excelsa. These results lend credence to the traditional use of these plants in Cote d'Ivoire's ethnomedicine for the treatment of anaemia.