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Dublin, Ireland

University College Dublin - formally known as University College Dublin - National University of Ireland, Dublin is Ireland's largest, and the island of Ireland's second largest, university, with over 1,300 faculty and 17,000 undergraduate students. It is located in Dublin, the Irish capital. Wikipedia.

Kelly B.D.,University College Dublin
British Journal of Psychiatry | Year: 2014

The United Nations Convention on the Rights of Persons with Disabilities is a welcome articulation of the rights of the disabled. However, as its definition of disability appears to include mental illness, the UK appears to violate it by linking mental illness with detention. Clarity and, possibly, change are needed.

The electronic structure of the TiO2(110) surface interfaced with both a semiconducting and metallic carbon nanotube (CNT) was investigated by density functional theory. Our simulations rationalized visible light photocatalytic activity of CNT/TiO2 hybrid materials higher than that under ultraviolent irradiation and showed that the photoactivity of a semiconducting CNT decorating TiO2 is better than that of the metallic CNT/TiO2 system due to efficient charge separation across the interface. This suggests that semiconducting CNT/TiO2 could be a potential photovoltaic material. In contrast, strong interaction between a metallic CNT and TiO2 leads to large charge transfer. Such charge transfer reduces the built-in potential, in turn resulting in inefficient charge separation. Functionalizing the metallic CNT with a small platinum cluster can increase the built-in potential and drive charge separation. These observations indicate that the CNT/TiO2 interface can be a potential photovoltaic material by a metal cluster decorating a CNT despite a real tube being composed of the mixture of metallic and semiconducting CNTs. © 2013 American Chemical Society.

McGettigan P.A.,University College Dublin
Current Opinion in Chemical Biology | Year: 2013

The transcriptomics field has developed rapidly with the advent of next-generation sequencing technologies. RNA-seq has now displaced microarrays as the preferred method for gene expression profiling.The comprehensive nature of the data generated has been a boon in terms of transcript identification but analysis challenges remain. Key among these problems is the development of suitable expression metrics for expression level comparisons and methods for identification of differentially expressed genes (and exons). Several approaches have been developed but as yet no consensus exists on the best pipeline to use.De novo transcriptome approaches are increasingly viable for organisms lacking a sequenced genome. The reduction in starting RNA required has enabled the development of new applications such as single cell transcriptomics.The emerging picture of mammalian transcription is complex with further refinement expected with the integration of epigenomic data generated by projects such as ENCODE. © 2013 Elsevier Ltd.

Fitzgerald D.J.,University College Dublin
Circulation research | Year: 2013

The development of drugs that inhibit platelets has been driven by a combination of clinical insights, fundamental science, and sheer luck. The process has evolved as the days of stumbling on therapeutic gems, such as aspirin, have long passed and have been replaced by an arduous process in which a drug is designed to target a specific protein implicated in a well-characterized pathophysiological process, or so we would like to believe. The development of antiplatelet therapy illustrates the importance of understanding the mechanisms of disease and the pharmacology of the compounds we develop, coupled with careful clinical experimentation and observation and, yes, still, a fair bit of luck.

Albrecht M.,University College Dublin
Chemical Reviews | Year: 2010

A study was conducted some of the fundamental aspects and the latest trends in the field of cyclometalation using d-block transition metals. It was revealed that cyclometalation had emerged as one of the most popular organometallic reactions, providing a simple entry to organometallic compounds. It allowed for the investigation of the essential aspects governing the metal-mediated activation of unreactive bonds, such as the C-H bond. The study covered seminal fundamental literature and the latest highlights and the trends that emerged till early 2009. Cyclometalation gained significance due to the reaction representing the mildest route for achieving strong C-H and C-R bonds. It had also emerged as an attractive and versatile synthetic method for creating organometallic entities with significantly wide application potential.

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