University College Dublin - formally known as University College Dublin - National University of Ireland, Dublin is Ireland's largest, and the island of Ireland's second largest, university, with over 1,300 faculty and 17,000 undergraduate students. It is located in Dublin, the Irish capital. Wikipedia.
University College Dublin and Foundation Scholars And The Other Members Of Board | Date: 2016-06-28
(E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.
University College Dublin | Date: 2016-11-11
The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TP) or TPbeta (TP) receptor subtype.
University College Dublin and Foundation Scholars And The Other Members Of Board | Date: 2017-03-29
University College Dublin | Date: 2017-03-22
A composition comprising a silica-based nanobead having its surface functionalized by a moiety selected from moieties that are reactive to and combine with a fouling layer on a material surface.
University College Dublin | Date: 2017-05-17
A non-therapeutic method of improving growth performance of a weaning mammal comprises a step of administering to the weaning mammal or a maternal mammal an effective amount of beta-glucan and casein hydrolysate, wherein the weight ratio of beta-glucan to casein hydrolysate is 1:2 to 2:1. A dietary supplement suitable for oral administration to a mammal comprising beta-glucan and casein hydrolysate is also provided, wherein the weight ratio of beta-glucan to casein hydrolysate is 1:2 to 2:1.
University College Dublin and University of Limerick | Date: 2017-03-22
A peptide having 12 to 60 amino acids and including (a) a sequence of SEQUENCE ID NO: 11, or (b) a fragment of SEQUENCE ID NO: 11 that includes the sequence of SEQUENCE ID NO: 1 or 5, is described for use in improving glycemic management in a mammal. A composition, for example a food product, that includes substantially all of the peptides of SEQUENCE ID NO:s 1 to 11, that is capable of reducing post-prandial blood glucose levels, and increasing insulin secretion in humans, is also described.
University College Dublin | Date: 2017-04-26
Embodiments of the present invention produce and define a relationship between local voltage and power measurements at a node of an electrical network and system conditions on a remote branch of the network. These local measurements are used to determine an optimal voltage set point at the node that, if realised by a reactive power resource, would affect the flow of reactive power or line current at one or more particular remote branches of the power system in a manner captured by the derived relationship. The change in reactive power required to obtain this voltage set point is also calculated based on local measurements.
University College Dublin | Date: 2017-04-05
A process for the stereoselective preparation of a chiral alcohol or a chiral amine, the process comprising reacting a first prochiral reactant selected from the group consisting of a ketone, an aldehyde, and an inline, with a second reactant comprising a Grignard reagent, in the presence of a chiral trans-diamim of formula (1) as defined herein. Also provided is the use of the chiral trans-diamine of formula (1) in a Grignard reaction and the chiral trans-diamines per se.
Albrecht M.,University College Dublin
Chemical Reviews | Year: 2010
A study was conducted some of the fundamental aspects and the latest trends in the field of cyclometalation using d-block transition metals. It was revealed that cyclometalation had emerged as one of the most popular organometallic reactions, providing a simple entry to organometallic compounds. It allowed for the investigation of the essential aspects governing the metal-mediated activation of unreactive bonds, such as the C-H bond. The study covered seminal fundamental literature and the latest highlights and the trends that emerged till early 2009. Cyclometalation gained significance due to the reaction representing the mildest route for achieving strong C-H and C-R bonds. It had also emerged as an attractive and versatile synthetic method for creating organometallic entities with significantly wide application potential.
Braun H.-B.,University College Dublin
Advances in Physics | Year: 2012
Micromagnetics has been the method of choice to interpret experimental data in the area of microscopic magnetism for several decades. In this article, we show how progress has been made to extend this formalism to include thermal and quantum fluctuations in order to describe recent experimental developments in nanoscale magnetism. For experimental systems with constrained dimensions such as nanodots, atomic chains, nanowires, and thin films, topological defects such as solitons, vortices, skyrmions, and monopoles start to play an increasingly important role, all forming novel types of quasiparticles in patterned low-dimensional magnetic systems. We discuss in detail how soliton-antisoliton pairs of opposite chirality form non-uniform energy barriers against thermal fluctuations in nanowires or pillars. As a consequence of their low barrier energy compared to uniform reversal, they limit the thermal stability of perpendicular recording media. For sufficiently short samples, the non-uniform energy barrier continuously merges into the conventional uniform Néel-Brown barrier. Partial formation of chiral domain walls also determines the magnetic properties of granular nanostructured magnets and exchange spring systems. For a long time, the reconciliation between micromagnetics and quantum mechanics has remained an unresolved challenge. Here it is demonstrated how inclusion of Berry's phase in a micromagnetic action allows for a semiclassical quantization of spin systems, a method that is demonstrated by the simple example of an easy-plane spin. This powerful method allows for a description of quantum dynamics of solitons and breathers which in the latter case agrees with the anisotropic spin-XYZ-model. The domain wall or soliton chirality plays an important role as it is coupled to the wavevector of the quasiparticle dispersion. We show how this quantum soliton chirality is detected by polarized neutron scattering in one-dimensional quantum antiferromagnets. © 2012 Taylor & Francis.