Childrens University Hospital Erlangen

Weißenburg in Bayern, Germany

Childrens University Hospital Erlangen

Weißenburg in Bayern, Germany

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Peters C.,St Anna Childrens Hospital | Matthes-Martin S.,St Anna Childrens Hospital | Poetschger U.,St Anna Childrens Hospital | Schrappe M.,University of Kiel | And 19 more authors.
Journal of Clinical Oncology | Year: 2015

Purpose Although hematopoietic stem-cell transplantation is widely performed in children with high-risk acute lymphoblastic leukemia (ALL), the influence of donor types is poorly understood. Thus, transplantation outcomes were compared in the prospective multinational Berlin-Frankfurt-Muenster (BFM) study group trial: ALL-SCT-BFM 2003 (Allogeneic Stem Cell Transplantation in Children and Adolescents with Acute Lymphoblastic Leukemia). Patients and Methods After conditioning with total-body irradiation and etoposide, 411 children with high-risk ALL received highly standardized stem-cell transplantations during the first or later remissions. Depending on donor availability, grafts originated from HLA-genoidentical siblings or from HLA-matched unrelated donors who were identified and matched by high-resolution allelic typing and were compatible in at least 9 of 10 HLA loci. Results Four-year event-free survival (- standard deviation [SD]) did not differ between patients with transplantations from unrelated or sibling donors (0.67 - 0.03 v 0.71 - 0.05; P - .405), with cumulative incidences of nonrelapse mortality (- SD) of 0.10 - 0.02 and 0.03 - 0.02 (P - .017) and relapse rates (- SD) of 0.22 - 0.02 and 0.24 - 0.04 (P - .732), respectively. Among recipients of transplantations from unrelated donors, no significant differences in event-free survival, overall survival, or nonrelapse mortality were observed between 9/10 and 10/10 matched grafts or between peripheral blood stem cells and bone marrow. The absence of chronic graft-versus-host disease had no effect on event-free survival. Engraftment was faster after bone marrow transplantation from siblings and was associated with fewer severe infections and pulmonary complications. Conclusion Outcome among high-risk pediatric patients with ALL after hematopoietic stem-cell transplantation was not affected by donor type. Standardized myeloablative conditioning produced a low incidence of treatment-related mortality and effective control of leukemia. © 2015 by American Society of Clinical Oncology.

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