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El Kenz H.,Brugmann University Hospital Center | Corazza F.,Brugmann University Hospital Center | Van Der Linden P.,Brugmann University Hospital Center | Chabab S.,Brugmann University Hospital Center | Vandenvelde C.,Queen Astrid Base Hospital Center
Transfusion and Apheresis Science | Year: 2013

Prevention of transfusion-associated graft versus host disease (TA-GVHD) by gamma irradiation is known to induce increased K+ in supernatant of packed red blood cells (PRBCs) stored in CPDA-1 and SAGM conservative solutions. However, no data exist for PRBCs in AS-3 medium which is considered safe for neonatal transfusion. We evaluated haemolysis and K+ release from irradiated AS-3 PRBCs and compared our results with reported data for SAGM and CPDA-1 PRBCs. Our results indicate that irradiated PRBCs stored in AS-3 after more than 7. days post-irradiation should not be used in massive and/or rapidly infused transfusions in neonates and infants. © 2013 Elsevier Ltd.


Chappuis J.,Brugmann University Hospital Center | Boute P.,Brugmann University Hospital Center | Putz P.,Brugmann University Hospital Center
Orthopaedics and Traumatology: Surgery and Research | Year: 2011

Introduction: Fractures of the distal radius are very common and mainly occur in the elderly. There has been an increasing use of locked volar plate fixations which report satisfactory results. However, some authors advocate the use of nail fixation. Hypothesis: The aim of this study is to compare dorsal nail plate versus locked volar plate fixation in the treatment of distal radius fractures with dorsal tilt. Materials and methods: The mean age of the patients was over 50 years. The study included extra-articular distal radius fractures with posterior tilt. We conducted a prospective randomized study between December 2007 and February 2009 including a group of 16 patients treated with a dorsal nail fixation (group 1) and a group of 15 patients managed with a locked volar plate fixation (group II). We analyzed both the clinical results (complications, Range of motion [ROM], tightening strength, Disabilities of the Arm, Shoulder and Hand [DASH] and Mayo Clinic scores) and the radiographic results from A/P and lateral radiographs in the early postoperative period and at 6-month follow-up. Results: ROM toward extension was better in the volar plating subgroup (group I, 42.5°, group II, 57.5°; P< 0.05). Pronation mobility was better in the dorsal nail subgroup (group I, 85°; group II, 80°; P< 0.05). The locked volar plate fixation subgroup demonstrated a better recovery of the tightening strength as compared with the uninjured side (group I, 78%, group II, 90%, P=0.03). The DASH score was similar in both groups (group I, 22.09 ± 22.9; group II, 20.62 ± 20.3, P>0.05). The Mayo Clinic score was better in the locked volar plate fixation subgroup (group I, 65 ± 13.4; group II, 85.6 ± 19.2; P=0.002). Radiographic results were good in both groups, however anatomical reduction of the volar tilt was significantly better in group II (plate) when compared with the uninjured side. Moreover, we report on two cases of tendinous damages to the long extensor muscle of the thumb in the dorsal nail fixation subgroup despite the use of a minimally invasive implant. Conclusion: The management of distal radius fractures with locked volar plate fixation in active elderly patients has proved successful and leads to better results than nail fixation regarding both reduction quality and objective functional scores. Level of evidence: Level II, prospective, randomized of low-level. © 2011 Elsevier Masson SAS.

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