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Piacenza d'Adige, Italy

Flamini R.,Italian Agricultural Research Council | De Rosso M.,Italian Agricultural Research Council | Bavaresco L.,University Cattolica Science
Journal of Analytical Methods in Chemistry

Suspect screening analysis is a targeted metabolomics method in which the identification of compounds relies on specific available information, such as their molecular formula and isotopic pattern. This method, coupled to liquid chromatography-high-resolution mass spectrometry, is effective in the study of grape metabolomics, in particular for characterization of flavonols, stilbene derivatives, and anthocyanins. For identification of compounds expected in the samples, a new database of putative compounds was expressly constructed by using the molecular information on potential metabolites of grape and wine from the literature and other electronic databases. Currently, this database contains around 1,100 compounds. The method allows identification of several hundred grape metabolites with two analyses (positive and negative ionization modes), and performing of data reprocessing using "untargeted" algorithms also provided the identification of some flavonols and resveratrol trimers and tetramers in grape for the first time. This approach can be potentially used in the study of metabolomics of varieties of other plant species. © 2015 Riccardo Flamini et al. Source

Brunetti S.,University of Siena | Dulio P.,Polytechnic of Milan | Peri C.,University Cattolica Science
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

In Discrete Tomography there is a wide literature concerning (weakly) bad configurations. These occur in dealing with several questions concerning the important issues of uniqueness and additivity. Discrete lattice sets which are additive with respect to a given set S of lattice directions are uniquely determined by X-rays in the direction of S. These sets are characterized by the absence of weakly bad configurations for S. On the other side, if a set has a bad configuration with respect to S, then it is not uniquely determined by the X-rays in the directions of S, and consequently it is also non-additive. Between these two opposite situations there are also the non-additive sets of uniqueness, which deserve interest in Discrete Tomography, since their unique reconstruction cannot be derived via the additivity property. In this paper we wish to investigate possible interplays among such notions in a given lattice grid, under X-rays taken in directions belonging to a set S of four lattice directions. © 2013 Springer-Verlag Berlin Heidelberg. Source

Biggeri A.,University of Florence | Tallacchini M.,University Cattolica Science
Science and Engineering Ethics

The different and seemingly unrelated practices of Information and Communication Technologies (ICT) used to collect and share personal and scientific data within networked communities, and the organized storage of human genetic samples and information—namely biobanking—have merged with another recent epistemic and social phenomenon, namely scientists and citizens collaborating as “peers” in creating knowledge (or peer-production of knowledge). These different dimensions can be found in joint initiatives where scientists-and-citizens use genetic information and ICT as powerful ways to gain more control over their health and the environment. While this kind of initiative usually takes place only after rights have been infringed (or are put at risk)—as the two cases presented in the paper show—collaborative scientists-and-citizens’ knowledge should be institutionally allowed to complement and corroborate official knowledge-supporting policies. © 2015 Springer Science+Business Media Dordrecht Source

Dulio P.,Polytechnic of Milan | Peri C.,University Cattolica Science
International Symposium on Image and Signal Processing and Analysis, ISPA

An algorithm is presented which constructs bounded non-additive sets uniquely determined by discrete parallel X-rays taken along prescribed lattice directions. Examples in dimension n = 3 and n = 3 are given, and related remarks are also provided. 2000 Mathematics Subject Classification. Primary 05D05; Secondary 05A17; 11P81. © 2013 University of Trieste and University of Zagreb. Source

Onofrj M.,University of Chieti Pescara | Bonanni L.,University of Chieti Pescara | Delli Pizzi S.,University of Chieti Pescara | Caulo M.,University of Chieti Pescara | And 4 more authors.
Medicine (United States)

Levitation and tentacular movements (LTM) are considered specific, yet rare (30%), features of Corticobasal Syndrome (CBS), and are erroneously classified as alien hand. Our study focuses on these typical involuntary movements and aims to highlight possible neural correlates. LTM were recognizable during functional magnetic resonance imaging (fMRI) in 4 of 19 CBS patients. FMRI activity was evaluated with an activation recognition program for movements, during LTM, consisting of levitaton and finger writhing, and compared with the absence of movement (rest) and voluntary movements (VM), similar to LTM, of affected and unaffected arm-hand. FMRI acquisition blocks were balanced in order to match LTM blocks with rest and VM conditions. In 1 of the 4 patients, fMRI was acquired only during LTM and with a different equipment. Despite variable intensity and range of involuntary movements, evidenced by videos, fMRI showed, during LTM, a significant (P<0.05-0.001) activation only of the contralateral primary motor cortex (M1). Voluntary movements of the affected and unaffected arm elicited the known network including frontal, supplementary, sensory-motor cortex, and cerebellum. Willed movements of the LTM-affected arm induced higher and wider activation of contralateral M1 compared with the unaffected arm. The isolated activation of M1 suggests that LTM is a cortical disinhibition symptom, not involving a network. Higher activation of M1 during VM confirms that M1 excitability changes occur in CBS. Our study calls, finally, attention to the necessity to separate LTM from other alien hand phenomena. © 2015 Wolters Kluwer Health, Inc. Source

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