Economic order quantity distribution policies in vendor-managed inventory routing problems and three-level distribution system [Políticas de distribuição com lote econômico de entrega em problemas de roteirização com estoque gerenciado pelo fornecedor e sistema logístico em três níveis]
Guimaraes T.,Centro Universitario Franciscano do Parana |
Guimaraes T.,Federal University of Paraná |
Scarpin C.,Federal University of Paraná |
Steiner M.T.,University Catolica do Parana
Gestao e Producao | Year: 2015
In vendor-managed inventory systems, logistics decisions are centralized at the vendor, allowing inventory storage and transportation costs to be reduced simultaneously. The operation of such systems requires the solution of a complex combinatorial optimization problem, known as Inventory Routing Problem (IRP), which involves managing client inventory and determining the frequency and size of product deliveries as well as the route taken by the vehicle over a given planning horizon. We present three new dynamic formulations for an economic order quantity distribution policy for the multivehicle inventory routing problem (MIRP). A mixed-integer linear programming (MILP) model with additional practical constraints was used for the MIRP, considering a three-echelon logistic system. A new heuristic approach that breaks the MIRP down into the following two sub-problems was also proposed: the first sub-problem deals with the scheduling of deliveries and the formation of delivery clusters over the planning horizon; the second sub-problem builds the routes for the delivery clusters using classic route construction heuristics and a procedure for intra-route improvements. Adjustments between routes are performed with the aid of a new large neighborhood search (LNS) strategy. Small, medium, and large scenarios with different storage and transportation costs were generated using parameters based on data from the literature. Extensive computational tests were carried out to determine the effectiveness of the proposed distribution policy and the heuristic used.
Respiratory activity of apical meristems of plagiotropic branches of Araucaria angustifolia (Bertol.) Kuntze [Atividade respiratória de meristemas apicais de ramos plagiotrópicos de Araucaria angustifolia (Bertol.) Kuntze]
Pereira G.P.,Federal University of Paraná |
Zanette F.,Federal University of Paraná |
Biasi L.A.,Federal University of Paraná |
de Carvalho R.I.N.,University Catolica do Parana
Ciencia Florestal | Year: 2016
Araucaria angustifolia decreases its growth ratio during the fall and winter in response to adverse environmental conditions such as in temperate fruits where bud dormancy as a survival startegy. The aim of this study was to evaluate the dynamics of the respiratory activity of apical meristems of plagiotropic branches of Araucaria angustifolia. To determine the respiratory activity, samples with 0.4 g of apical buds of plagiotropic branches of young and adult plants were collected. These buds were maintained during two hours in 5 mL of 2,3,5-triphenyl tetrazolium chloride (1.2%) in a growth room at 25 °C. Then, it was maintained during one hour in 4 mL of absolute ethyl alcohol and then the absorbance was determined by reading in spectrophotometer at 560 nm. The respiratory activity of apical meristems of plagiotropic branches of Araucaria angustifolia changed during the year, reducing in mid-spring and become lower in the winter in both young and adult plants. Adult plants remained with lower respiratory activity for a longer period, until the beginning of summer. © 2016, Universidade Federal de Santa Maria. All rights reserved.
Busnardo V.L.,University Catolica do Parana |
Biondo-Simoes M.L.P.,Federal University of Paraná
Revista Brasileira de Fisioterapia | Year: 2010
Objective: To evaluate the effects of low-level helium-neon (HeNe) laser on cutaneous wound healing in rats. Methods: Sixty Wistar rats were divided into control group and experimental group. A sutured longitudinal, dorsal-medial incision was made, with simple separate stitches. The experimental group was irradiated daily in three areas of the wound with HeNe laser (5mW maximum continuous power, 632.8 nm wavelength, 4 J/cm2 energy density and 0.015 cm2 laser beam area) for 36 seconds. The areas were evaluated on the third, seventh and fourteenth days postoperative. Histological sections were stained with hematoxylin-eosin to determine the type of inflammatory reaction according to the protocol by Vizzotto et al. (2003)* and with Picrosirius to identify types I and III collagen and the collagen maturation index (CMI). Immunohistochemical detection was employed with anti-CD45-LCA to recognize the inflammatory cells. Results: Both groups had the same inflammatory pattern. The experimental group had fewer inflammatory cells at the three evaluation times (p<0.001) with faster reduction in the number of leukocytes. The experimental group had greater total collagen density on the third day (p=0.001), with more type III collagen (p=0.001) and more type I collagen (p=0.001). There was no significant difference in the CMI. Conclusion: Low-level laser irradiation does not change the quality of the inflammatory response, but it does reduce its intensity; it increases collagen deposition in the early stages of the healing process and does not interfere with collagen maturation. © Revista Brasileira de Fisioterapia.
Dos Santos G.H.,Federal University of Paraná |
Mendes N.,University Catolica do Parana
Proceedings of Building Simulation 2011: 12th Conference of International Building Performance Simulation Association | Year: 2011
A mathematical model to simulate an unsaturated highly capacitive porous medium on roof (sand) is considered in order to predict its effects on building passive cooling. The present methodology is based on the theory of Philip and De Vries, using the thermophysical properties for different types of porous medium (building envelope) with different chemical composition and porous size distribution. The governing equations were discretized using the finite-volume method for describing the physical phenomena of heat and mass transfer in unsaturated porous medium. The robust MultiTriDiagonal-Matrix Algorithm (MTDMA) was used to solve this strongly-coupled problem, allowing the use of large time steps for long-term simulations. In order to precisely predict room air temperature and humidity, a lumped transient approach for a building room is considered. Comparisons of the sand layer effect in terms of heat fluxes through a horizontal roof, indoor conditions and thermal comfort (PMV - Predicted Mean Vote) are presented.
Dos Santos G.H.,Federal University of Paraná |
Mendes N.,University Catolica Do Parana
Applied Thermal Engineering | Year: 2013
A mathematical model to simulate an unsaturated sandy roof is considered in order to predict its effects on building passive cooling. The present methodology is based on the theory of Philip and De Vries, using the hygrothermal properties for different types of building envelope porous materials. The governing equations have been discretized using the finite-volume method for modeling the physical phenomena of heat and mass transfer in unsaturated porous media and they have been solved by using the MultiTriDiagonal-Matrix Algorithm (MTDMA), avoiding numerical instability related problems due to the strong coupling between the mass and energy conservation equations. In order to predict the room air temperature and relative humidity, a lumped transient approach for a building room has been considered. Comparisons of the sand layer effect on the heat flux through a horizontal roof and on the indoor psychrometrics conditions are discussed. © 2012 Elsevier Ltd. All rights reserved.
PubMed | Federal University of Paraná and University Catolica do Parana
Type: Journal Article | Journal: Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia | Year: 2016
p-cresol (PC) and p-cresyl sulfate (PCS) are responsible for many of the uremia clinical consequences, such as atherosclerosis in Chronic Kidney Disease (CKD) patients.We investigate the in vitro impact of PC and PCS on monocyte chemoattractant protein-1 (MCP-1) expression via NF-kappa B (NF-B) p65 in VSMC.PCS was synthesized by PC sulfatation. VSMC were extracted by enzymatic digestion of umbilical cord vein and characterized by immunofluorescence against -actin antibody. The cells were treated with PC and PCS at their normal (n), uremic (u) and maximum uremic concentrations (m). Cell viability was assessed by MTT. MCP-1 expression was investigated by ELISA in cells supernatants after toxins treatment with or without the NF-B p65 inhibitor.There was no significant difference in cell viability after toxins treatment for all concentrations tested. There was a significant increase in MCP-1 expression in cells treated with PCu and PCm (p < 0.001) and PCSn, PCSu and PCSm (p < 0.001), compared with the control. When VSMC were treated with the NF-B p65 inhibitor plus PCu and PCm, there was a significant decrease in MCP-1 production (p < 0.005). This effect was not observed with PCS.VSMC are involved in atherosclerosis lesion formation and production of MCP-1, which contributes to the inflammatory response initiation. Our results suggest that PC mediates MCP-1 production in VSMC, probably through NF-B p65 pathway, although we hypothesize that PCS acts through a different subunit pathway since NF-B p65 inhibitor was not able to inhibit MCP-1 production.
Dos Santos G.H.,Federal Technological University of Paraná |
Mendes N.,University Catolica do Parana
Proceedings of BS 2013: 13th Conference of the International Building Performance Simulation Association | Year: 2013
Multidimensional effects through porous building elements is barely explored in the literature due to many difficulties such as modeling complexity, computer run time, numerical convergence and highly moisture-dependent properties. Furthermore, when the multidimensional effect is considered, thermal bridges may play an important role on the hygrothermal building performance due to local increase of heat and mass flux densities. Therefore, in order to analyze the effects of building lower and upper corners, a multidimensional model has been developed to calculate the coupled heat, air and moisture transfer through building envelopes. For improving the discretized model numerical stability, the algebraic equations are simultaneously solved for the three driving potentials: temperature, vapor pressure and gas pressure gradients. In the results section, the coupling of the upper corner, wall, lower corner, ground and floor are analyzed for different boundary conditions in terms of temperature and relative humidity profiles, vapor flow and heat flux, showing the importance of a detailed hygrothermal analysis for accurately predicting building energy consumption, thermal comfort and mould growth risk. Copyright © 2011 by IPAC'11/EPS-AG.
Adalimumab for maintenance therapy for one year in Crohns disease: Results of a Latin American single-center observational study [Adalimumabe na terapia de manutenção por um ano na doença de Crohn: Resultados de um estudo observacional unicêntrico Latinoamericano]
Kotze P.G.,University Catolica do Parana |
Abou-Rejaile V.R.,University Catolica do Parana |
Uiema L.A.,University Catolica do Parana |
Olandoski M.,University Catolica do Parana |
And 4 more authors.
Arquivos de Gastroenterologia | Year: 2014
Context - Adalimumab is a fully-human antibody that inhibits TNF alpha, with a significant efficacy for long-term maintenance of remission. Studies with this agent in Latin American Crohn's disease patients are scarce. Objectives - The objective of this study was to outline clinical remission rates after 12 months of adalimumab therapy for Crohn's disease patients. Methods - Retrospective, single-center, observational study of a Brazilian case series of Crohn's disease patients under adalimumab therapy. Variables analyzed: demographic data, Montreal classification, concomitant medication, remission rates after 1, 4, 6 and 12 months. Remission was defined as Harvey-Bradshaw Index ≤4, and non-responder-imputation and last-observation-carried-forward analysis were used. The influence of infliximab on remission rates was analyzed by Fischer and Chi-square tests (P<0.05). Results - Fifty patients, with median age of 35 years at therapy initiation, were included. Remission rates after 12 months of therapy were 54% under non-responder-imputation and 88% under last-observation-carried-forward analysis. After 12 months, remission on patients with previous infliximab occurred in 69.23% as compared to 94.59% in infliximab-naïve patients (P = 0.033). Conclusions - Adalimumab was effective in maintaining clinical remission after 12 months of therapy, with an adequate safety profile, and was also more effective in infliximab naïve patients.
PubMed | University Catolica do Parana
Type: | Journal: Revista da Escola de Enfermagem da U S P | Year: 2012
The debate is based on the contextualization of the goals presented by the National Primary Health Care Plan (Plano Nacional de Ateno Bsica), which despite having improved the quality and attempted to solve inequities and vulnerabilities, still has contradictions to overcome. The plan discusses that nursing, in this setting, is included as a member of the family health team and in the coordination of community health agents. The analysis of the challenges to be overcome was divided into three blocks: undergraduate teaching, the working process, and continuous training. The first block presents a panorama of undergraduates studies in Brazil and how the primary health care issues are addressed in the curricula and understood by faculty and students; the second examines the views that primary health care nurses have about their working process and the guidelines of the Brazilian National Health System; finally, the third block points to the challenges related to the different knowledge and practices that must be developed in nursing, in this specific area of practice.
PubMed | University Catolica do Parana and São Paulo State University
Type: Clinical Trial | Journal: Arquivos de gastroenterologia | Year: 2014
Adalimumab is a fully-human antibody that inhibits TNF alpha, with a significant efficacy for long-term maintenance of remission. Studies with this agent in Latin American Crohns disease patients are scarce.The objective of this study was to outline clinical remission rates after 12 months of adalimumab therapy for Crohns disease patients.Retrospective, single-center, observational study of a Brazilian case series of Crohns disease patients under adalimumab therapy. Variables analyzed: demographic data, Montreal classification, concomitant medication, remission rates after 1, 4, 6 and 12 months. Remission was defined as Harvey-Bradshaw Index 4, and non-responder-imputation and last-observation-carried-forward analysis were used. The influence of infliximab on remission rates was analyzed by Fischer and Chi-square tests (P<0.05).Fifty patients, with median age of 35 years at therapy initiation, were included. Remission rates after 12 months of therapy were 54% under non-responder-imputation and 88% under last-observation-carried-forward analysis. After 12 months, remission on patients with previous infliximab occurred in 69.23% as compared to 94.59% in infliximab-nave patients (P = 0.033).Adalimumab was effective in maintaining clinical remission after 12 months of therapy, with an adequate safety profile, and was also more effective in infliximab nave patients.