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Castelló de la Plana, Spain

Pozo-Rodriguez F.,Institute Investigacion | Pozo-Rodriguez F.,Institute Salud Carlos II | Lopez-Campos J.L.,Institute Salud Carlos II | Lopez-Campos J.L.,Hospital Universitario Virgen Del Rocio | And 16 more authors.
PLoS ONE | Year: 2012

Backgrounds: AUDIPOC is a nationwide clinical audit that describes the characteristics, interventions and outcomes of patients admitted to Spanish hospitals because of an exacerbation of chronic obstructive pulmonary disease (ECOPD), assessing the compliance of these parameters with current international guidelines. The present study describes hospital resources, hospital factors related to case recruitment variability, patients' characteristics, and adherence to guidelines. Methodology/Principal Findings: An organisational database was completed by all participant hospitals recording resources and organisation. Over an 8-week period 11,564 consecutive ECOPD admissions to 129 Spanish hospitals covering 70% of the Spanish population were prospectively identified. At hospital discharge, 5,178 patients (45% of eligible) were finally included, and thus constituted the audited population. Audited patients were reassessed 90 days after admission for survival and readmission rates. A wide variability was observed in relation to most variables, hospital adherence to guidelines, and readmissions and death. Median inpatient mortality was 5% (across-hospital range 0-35%). Among discharged patients, 37% required readmission (0-62%) and 6.5% died (0-35%). The overall mortality rate was 11.6% (0-50%). Hospital size and complexity and aspects related to hospital COPD awareness were significantly associated with case recruitment. Clinical management most often complied with diagnosis and treatment recommendations but rarely (<50%) addressed guidance on healthy life-styles. Conclusions/Significance: The AUDIPOC study highlights the large across-hospital variability in resources and organization of hospitals, patient characteristics, process of care, and outcomes. The study also identifies resources and organizational characteristics associated with the admission of COPD cases, as well as aspects of daily clinical care amenable to improvement. © 2012 Pozo-Rodríguez et al. Source


Bruna S.,Autonomous University of Madrid | Cuadrado I.,Autonomous University of Madrid | Delgado E.,Autonomous University of Madrid | Gomez-Garcia C.J.,Institute Ciencia Molecular | And 8 more authors.
Dalton Transactions | Year: 2014

Reaction of Fe3(CO)12 with 1,2-dithiolene HSC 6H2Cl2SH affords a mixture of complexes [Fe2(CO)6(μ-SC6H2Cl 2S)] 1, [Fe2(SC6H2Cl 2S)4] 2 and [Fe3(CO) 7(μ3-SC6H2Cl2S) 2] 3. In the course of the reaction the trimetallic cluster 3 is first formed and then converted into the known dinuclear compound 1 to afford finally the neutral diiron tetrakis(dithiolato) derivative 2. Compounds 2 and 3 have been studied by Mössbauer spectroscopy, X-ray crystallography and theoretical calculations. In compound 2 the metal atoms are in an intermediate-spin FeIII state (SFe = 3/2) and each metal is bonded to a bridging dithiolene ligand and a non-bridging thienyl radical (S = 1/2). Magnetic measurements show a strong antiferromagnetic coupling in complex 2. Cyclic voltammetry experiments show that the mixed valence trinuclear cluster 3 undergoes a fully reversible one electron reduction. Additionally, compound 3 behaves as an electrocatalyst in the reduction process of protons to hydrogen. © 2014 The Royal Society of Chemistry. Source


Hernandez-Escolano M.,Universidad Politecnica de Ingenieria | Juan-Diaz M.J.,University of the Basque Country | Martinez-Ibanez M.,University of the Basque Country | Suay J.,University Castellon | And 2 more authors.
Journal of Materials Science: Materials in Medicine | Year: 2013

Surface engineering of biomaterials could promote the osseointegration of implants. In this work, two types of hybrid sol-gel materials were developed to stimulate cell attachment, proliferation and differentiation of osteogenic cells. One type was synthesised from vinyl triethoxysilane (VTES) and tetraethyl-orthosilicate (TEOS) at different molar ratios, while the other from VTES and hydroxyapatite particles (HAp). Hybrid materials were systematically investigated using nuclear magnetic resonance, Fourier transform infrared spectroscopy and contact angle metrology. The biocompatibility and osseoinduction of the coatings were evaluated by measuring mesenchymal stem cell proliferation using MTT assays and analysing the mineralised extracellular matrix production by quantifying calcium-rich deposits. The results highlighted the versatility of these coatings in obtaining different properties by changing the molar ratio of the VTES:TEOS precursors. Thus, mineralisation was stimulated by increasing TEOS content, while the addition of HAp improved cell proliferation but worsened mineralisation. © 2013 Springer Science+Business Media New York. Source


Hernandez-Escolano M.,Universidad Politecnica de Ingenieria | Juan-Diaz M.,University of the Basque Country | Martinez-Ibanez M.,University of the Basque Country | Jimenez-Morales A.,Charles III University of Madrid | And 3 more authors.
Journal of Sol-Gel Science and Technology | Year: 2012

The controlled release of active agents from a matrix has become increasingly important for oral, transdermal or implantable therapeutic systems, due to the advantages of safety, efficacy and patient convenience. Controlled-release hybrid (organic-inorganic) sol-gel coating synthesis has been performed to create a sol with an active molecule included (procaine). Synthesis procedures included acid-catalysed hydrolysis, sol preparation, the addition of a procaine solution to the sol, and the subsequent gelation and drying. The alkoxide precursors used were triethoxyvinylsilane and tetraethyl-orthosilicate (TEOS) in molar ratios of 1:0, 9:1, 8:2 and 7:3. After the determination of the optimal synthesis parameters, the material was physicochemically characterised by silicon-29 nuclear magnetic resonance ( 29Si-NMR) and Fourier transform infrared spectroscopy, contact angle analysis and electrochemical impedance spectroscopy tests. Finally, the materials were assayed in vitro for their ability to degrade by hydrolysis and to release procaine in a controlled manner. The sustained release of procaine over a 3-day period was demonstrated. A close correlation between release and degradation rates suggests that film degradation is the main mechanism underlying the control of release. Electrochemical analysis reveals the formation of pores and water uptake during the degradation. The quantity of TEOS is one of the principal parameters used to determine the kinetics of degradation and procaine release. © 2012 Springer Science+Business Media, LLC. Source


Juan-Diaz M.J.,University of the Basque Country | Martinez-Ibanez M.,University of the Basque Country | Lara-Saez I.,University Castellon | da Silva S.,University Castellon | And 4 more authors.
Progress in Organic Coatings | Year: 2016

Ti implants osteointegration is widely recognized. However, silicon deficiency in animals leads to bone defects, since this element plays an important role in bone metabolism. Thus, hybrid (organic-inorganic) sol-gel coatings synthesis has been performed to create a material able to release silicon compounds under in vivo conditions, to promote a fast and good osseointegration. Synthesis procedures included acid-catalysed hydrolysis, sol preparation and the subsequent gelation and drying. To this end, methyl-trimethoxysilane (MTMOS) and 3-glycidoxypropyl-trimethoxysilane (GPTMS), alkoxide precursors with different molar ratios were used. After the determination of the optimal synthesis parameters to obtain homogeneous films, the materials were physicochemically characterized by 29Si nuclear magnetic resonance (29Si NMR), Fourier transform infrared spectroscopy (FT-IR), contact angle measurements and electrochemical impedance spectroscopy (EIS) tests. The materials were assayed in vitro for their ability to release Si in a controlled manner. The sustained release of Si over long periods was demonstrated. Electrochemical analysis revealed the formation of pores and water uptake during the degradation. The degradation kinetics and Si release of coatings was mainly influenced by the amount of GPTMS. Among the cell types involved in bone regeneration, human adipose tissue-derived mesenchymal stem cells (AMSCs) are included; thus, the attachment and proliferation of these cells onto the coatings was analyzed. Furthermore, the osteoinduction capacity of the coatings was evaluated by establishing the mineralized extracellular matrix production by quantification of calcium-rich deposits. MSCs had good cell proliferation onto the hybrid coatings and could be able to produce mineralized extracellular matrix, evidencing an active osteoinduction process. After the in vitro tests, one formulation was selected to coat titanium implants and perform an in vivo test in rabbits. Although the in vivo results were not as good as those obtained in vitro, we demonstrated that the ability to utilize sol-gel coating processes on titanium implants opened up the opportunity to tailor surfaces to clinical requirements. Thus, a further research is proposed to include other precursors that enhance the coating degradation kinetics in order to obtain an early release of Si compounds that accelerate the osseointegration. © 2016. Source

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