University CA

Riverside, CA, United States

University CA

Riverside, CA, United States
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Diome T.,University Ca | Diome T.,Institute Of Recherche Pour Le Developpement | Ndong A.,University Ca | Ndong A.,Institute Of Recherche Pour Le Developpement | And 10 more authors.
Journal of Asia-Pacific Entomology | Year: 2013

Caryedon serratus is found in different agro-ecological and agro-climatic zones, and its damage to groundnuts can vary up to an 80% quantitative loss of yield. This study seeks to demonstrate the effects of different agro-ecological refer to so as to very quickly process the content zones and the presence or absence of groundnut cultivation on the structure and genetic distribution of C. serratus in West Africa. Portions of the cytochrome b and 28S ribosomal genes of C. serratus were sequenced, using samples from four countries that represent different agro-ecological and agro-climatic sub-regions of West Africa. The results showed 37 haplotypes for the cytochrome b and 7 haplotypes for the 28S ribosomal gene. Although genetic diversity was different between agro-ecological zones tests show no significant differences in structuring according to agro-ecological zone. These tests, as well as the phylogenetic relationships that our results imply, indicate that there is a genetic differentiation between individuals from groundnut culturing areas compared to those from areas where the cultivation of groundnuts is absent or low. © 2013 Korean Society of Applied Entomology, Taiwan Entomological Society and Malaysian Plant Protection Society.

Chen Y.,University CA | Zheng D.,University CA | Miller P.A.,University CA | Farrell J.A.,Mine Safety Appliances
Proceedings of the IEEE Conference on Decision and Control | Year: 2013 Due to the short range over which electromagnetic fields decay in sea water, inertial navigation systems for underwater vehicles are often aided by acoustic timeof- flight positioning scheme. One widely implemented longbaseline (LBL) approach uses a ping-response protocol resulting in asynchronous measurements that depend on the state of the vehicle at two time instants. Due to these issues, the standard assumptions necessary for Extended Kalman Filter (EKF) solutions are not satisfied. This paper proposes a Near-Real-Time (NRT) Bayesian smoothing framework for the LBL aided INS application. Within this NRT framework, the navigation process is divided into the ping-response cycles of LBL transceiving. Before the end of a LBL cycle, a traditional realtime EKF is implemented using the IMU and standard aiding measurements. At the end of each LBL cycle, an optimal Bayesian trajectory estimator executes. This Maximum- A-Posteriori (MAP) estimation includes all the measurement information collected during the current LBL cycle. Furthermore, right after this smoothing process, the current EKF estimate is corrected by the corresponding MAP estimate. This article presents the theoretical solution, discusses the implementation, and presents simulation results to illustrate the accuracy and reliability of this Near-Real-Time approach. © 2013 IEEE.

Zheng D.,University CA | Vanitsthian R.,University CA | Chen G.,University CA | Farrell J.A.,University CA
Proceedings of the American Control Conference | Year: 2013

LED's offer multiuse opportunities related to illumination, communication, and navigation. These features enable reliable feature association for feature aided navigation. We introduce an aided navigation system that estimates the position and pose of the vehicle moving in a 2D plane using LED's and a high speed camera. No prior knowledge of the vehicle state is required due to initialization at the first time instant that provides measurements of at least two LED's. The data association problem is solved using the LEDs' unique IDs. The IDs are modulated respectively onto the LEDs' illumination and recovered by processing a sequence of images obtained by a high speed camera. © 2013 AACC American Automatic Control Council.

PubMed | University CA
Type: Journal Article | Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology | Year: 2016

3192 Background: Doc is an effective chemotherapeutic agent for CaP. It stabilizes the -subunit of tubulin, phosphorylates and inactivates the anti-apoptotic protein Bcl-2, and stabilizes the tumor suppressor protein p27 resulting in cell cycle arrest at M-phase and apoptosis. PS-341 is an inhibitor of the proteasome, which is necessary for the degradation of cellular proteins. By preventing degradation of proteins such as p27 or p53, PS-341 causes G1 and G2 cell cycle arrest. Because PS-341 inhibits cell cycling, it may be antagonistic to or limit the activity of taxanes, which show their greatest activity in M-phase. Our previous work with Doc plus erlotinib showed that intermittent delivery was more effective than either drug alone or given concurrently. We hypothesized that the combination of Doc and PS-341 would show similar sequence dependence to achieve the greatest cell kill.Flow cytometric analysis of DNA content was done to estimate the proportion of PC3 (p53 null) or LNCaP (p53 wild-type) cells in each cell cycle phase as well as sub-G1. Western blot analysis was used to evaluate protein levels.In PC3 cells, as single agents Doc was more effective than PS-341 (sub-G1: 21.8% and 7.3%, respectively). In combination, the sequence of DocPS-341 (sub-G1: 47.4%) was more effective than either PS-341Doc (sub-G1: 25.7%) or PS-341 + Doc (sub-G1: 6.3%). In LNCaP cells, there was little difference between Doc and PS-341 as single agents (sub-G1: 18.8% and 14.7%, respectively). However, Doc + PS-341 (sub-G1: 39.3%) given concurrently was more effective than either PSDoc or DocPS (sub-G1: 14.7 and 14.4%). p27 was shown to be up-regulated in all treatment groups, as expected. Initial PC3 xenograft studies showed slightly greater inhibition of tumor growth in combination treatments versus single agents.LNCaP (p53 wild-type) cells showed greater sensitivity to PS-341, particularly when given concurrently with Doc, than PC3 (p53 null) cells. These data support further studies into the role of p53, cell cycle arrest, and sequencing of treatment with PS-341 and Doc in CaP. (U01-CA-62505, N01-CM-17101, ACS-CRTG-0019701-CCE) [Table: see text].

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