Sant'Orsola Terme, Italy
Sant'Orsola Terme, Italy

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Abbate I.,Laboratorio Of Virologia | Piralla A.,SS Virologia Molecolare | Calvario A.,UOC Microbiologia e Virologia | Callegaro A.,UO di Microbiologia e Virologia | And 13 more authors.
Journal of Clinical Virology | Year: 2016

Background Inter-laboratory variability in quantifying pathogens involved in viral disease following transplantation may have a great impact on patient care, especially when pre-emptive strategies are used for prevention. Objectives The aim of this study was to analyze the variability in quantifying CMV, EBV and BKV DNA from 15 virology laboratories of the Italian Infections in Transplant Working Group (GLaIT) involved in monitoring transplanted patients. Study design Panels from international Quality Control programs for Molecular Diagnostics (QCMD, year 2012), specific for the detection of CMV in plasma, CMV in whole blood (WB), EBV and BKV were used. Intra- and inter-laboratory variability, as well as, deviations from QCMD consensus values were measured. Results 100% specificity was obtained with all panels. A sensitivity of 100% was achieved for EBV and BKV evaluations. Three CMV samples, with concentrations below 3 log10 copies/ml, were not detected by a few centers. Mean intra-laboratory variability (% CV) was 1.6 for CMV plasma and 3.0 for CMV WB. Mean inter-laboratory variability (% CV) was below 15% for all of the tested panels. Inter-laboratory variability was higher for CMV in WB with respect to the CMV plasma panel (3.0 vs 1.6% CV). The percentiles 87.7%, 58.6%, 89.6% and 74.7% fell within ± 0.5 log10 difference of the consensus values for CMV plasma, CMV WB, EBV and BKV panels, respectively. Conclusions An acceptable intra- and inter-laboratory variability, in comparison with international standards was observed in this study. However, further harmonization in viral genome quantification is a reasonable goal for the future. © 2016 Elsevier B.V.

Caldarelli A.,University BolognaBologna | Caldarelli A.,University of Bologna | Cavani F.,University BolognaBologna | Cavani F.,University of Bologna | And 7 more authors.
DGMK Tagungsbericht | Year: 2012

This paper deals with a study on the gas-phase transformation of 1-butanol into maleic anhydride, using different types of catalysts. Indeed, catalytic acid properties are needed to dehydrate 1-butanol into 1-butene, whereas redox-type properties are required for the oxidation of the olefin into maleic anhydride. The two types of active sites can be combined in bifunctional systems, showing both acid and redox-type properties. We found that vanadyl pyrophosphate catalyzes the one-pot reaction, giving a maximum selectivity to maleic anhydride of 28%. In fact, various side reactions contributed to the formation of by-products, eg, 1-butanol (oxidative) dehydrogenation into butyraldehyde, formation of light carboxylic acids and carbon oxides, and condensation of unsaturated C4 intermediates (butenes and butadiene) with the formed maleic anhydride to yield heavier compounds.

Basile F.,University BolognaBologna | Basile F.,Centro Interdipartimentale Per la Ricerca Industriale | Cavani F.,University BolognaBologna | Cavani F.,Centro Interdipartimentale Per la Ricerca Industriale | And 7 more authors.
DGMK Tagungsbericht | Year: 2012

This paper deals with an investigation of hexagonal W-V-Nb-O and W-V-Mo-O bronzes as catalysts for the one-pot oxidehydration of glycerol into acrylic acid. In a previous work, we reported a study on a bi-component bronze W-V-O that allowed us to obtain a 25% acrylic acid selectivity; in the current work, the incorporation of either Nb or Mo in a tri-component bronze structure allowed us to tune the acid and redox properties of the catalyst, so as to study their influence on the overall reaction scheme.

Cavani F.,University BolognaBologna | Cocchi S.,University BolognaBologna | Comito M.,University BolognaBologna | Mari M.,University BolognaBologna | Passeri S.,University BolognaBologna
DGMK Tagungsbericht | Year: 2010

In this paper we report on the cyclic (chemical-loop) steam reforming of methanol using CoFe2O4 as the electron/O2- carrier, a technology for producing hydrogen without the coproduction of any C-containing compound. The spinel turned out to be an efficient system for the cyclic reforming of methanol, the performance being greatly affected by conditions used during the spinel reduction step, but the formation of coke could not be eliminated. However, the aim of producing nil or negligible amounts of CO during the spinel reoxidation step, the latter being carried out with steam as the oxidant, was achieved by producing a partly reduced spinel during the reductive step. Sintering phenomena were responsible for the fall in spinel activity.

PubMed | Riabilitazione Neuropsicologica and University BolognaBologna
Type: | Journal: Frontiers in behavioral neuroscience | Year: 2016

During intertemporal choice, humans tend to prefer small-sooner rewards over larger-delayed rewards, reflecting temporal discounting (TD) of delayed outcomes. Functional neuroimaging (fMRI) evidence has implicated the insular cortex in time-sensitive decisions, yet it is not clear whether activity in this brain region is crucial for, or merely associated with, TD behavior. Here, patients with damage to the insula (Insular patients), control patients with lesions outside the insula, and healthy individuals chose between smaller-sooner and larger-later monetary rewards. Insular patients were less sensitive to sooner rewards than were the control groups, exhibiting reduced TD. A Voxel-based Lesion-Symptom Mapping (VLSM) analysis confirmed a statistically significant association between insular damage and reduced TD. These results indicate that the insular cortex is crucial for intertemporal choice. We suggest that he insula may be necessary to anticipate the bodily/emotional effects of receiving rewards at different delays, influencing the computation of their incentive value. Devoid of such input, insular patients choices would be governed by a heuristic of quantity, allowing patients to wait for larger options.

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