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Figueroa-Valverde L.,University Autonomic of Campeche | Diaz-Cedillo F.,National Polytechnic Institute of Mexico | Garcia-Cervera E.,University Autonomic of Campeche | Lopez-Ramos M.,University Autonomic of Campeche | Pool-Gomez E.,University Autonomic of Campeche
Asian Journal of Chemistry | Year: 2013

In this study, two brucine-steroid derivative were synthesized. In first stage, the brucine-androsterone derivative was development by the reaction of N1-(2,3-dimethoxystrychnidin-10-yliden)-ethane-1,2-diamine and androsteronehemisuccinate using as catalyst a carbodiimide derivative. The second stage was achieved by the reaction of N1-(2,3-dimethoxystrychnidin-10- yliden)-ethane-1,2-diamine with b-estradiol 17-hemisuccinate to form the brucine-estradiol conjugatein presence of a carbodiimide derivative.In conclusion, in this study we show a facile procedure for synthesis of two brucine-steroid derivatives. Source


Figueroa-Valverde L.,University Autonomic of Campeche | Diaz-Cedillo F.,National Polytechnic Institute of Mexico | Garcia-Cervera E.,University Autonomic of Campeche | Pool-Gomez E.,University Autonomic of Campeche | And 6 more authors.
Asian Journal of Chemistry | Year: 2013

In this study, two brucine derivative were synthetized; in first stage, the compound 1-{phenyl-[2-(2,3-dimethoxystrychnidin-10-yldeneamino)-ethylamino]- methyl}-naphtalen- 2-ol (4) was development by the reaction of β-naphthol, N1-(2,3-dimethoxystrychnidin-10-yliden)-ethane-1,2-diamine and benzaldehyde in ethanol. Also 4 was prepared by the reaction of brucine with 1-[(2-amino-ethylamino)-phenyl-methyl]-naphthalen-2-ol using as catalyst boric acid. In the second stage, the compound 4-hydroxy-N-[2-(2,3- dimethoxystrychnidin-10-ylideneamino)-ethyl]benzamide (8) was synthetized by the reaction of 4-hydroxybenzoic acid with N1-(2,3-dimethoxystrychnidin- 10-yliden)-ethane-1,2-diamine using a carbodiimide derivative as catalyst. Finally, in other experiment the compound 8 was also prepared by the reaction of brucine with N-(2-aminoethyl)-4-hydroxybenzamide in presence of a carbodiimide derivative. The structure of all compounds obtained was confirmed by elemental analysis and spectroscopic methods. © 2013 Asian Journal of Chemistry. Source

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