Pineda F.,Autonoma Of Colombia University |
Pineda F.,University of Los Andes, Colombia |
Pineda F.,Autonoma University |
Chica A.,Autonoma Of Colombia University |
And 2 more authors.
2010 IEEE ANDESCON Conference Proceedings, ANDESCON 2010 | Year: 2010
This article presents an alternative method for finding the state feedback matrix for MIMO systems from the model matrix polynomial fraction MPF. The proposed algorithm is recurrent state-feedback method for multivariable canonical forms. This algorithm tends to be more efficient at level structurally, but not computationally, because advances in simulation with the model MPF not yet have a clear prospect by using symbolic mathematics. This works shown a simple and easy handling that this model provides to engineers and researches. To facilitate and validate the algorithm, some functions have been developed with Matlab®, which are available in Matlab Mathworks Center. ©2010 IEEE. Source
Martin-Fernandez B.,Complutense University of Madrid |
Rubio-Navarro A.,Autonoma University |
Cortegano I.,Institute Salud Carlos III ISCIII |
Ballesteros S.,Complutense University of Madrid |
And 9 more authors.
PLoS ONE | Year: 2016
We aimed to evaluate macrophages heterogeneity and structural, functional and inflammatory alterations in rat kidney by aldosterone + salt administration. The effects of treatment with spironolactone on above parameters were also analyzed. Male Wistar rats received aldosterone (1 mgkg-1d-1) + 1% NaCl for 3 weeks. Half of the animals were treated with spironolactone (200 mg kg-1d-1). Systolic and diastolic blood pressures were elevated (p<0.05) in aldosterone + salt-treated rats. Relative kidney weight, collagen content, fibronectin, macrophage infiltrate, CTGF, Col I, MMP2, TNF-á, CD68, Arg2, and SGK-1 were increased (p<0.05) in aldosterone + salt-treated rats, being reduced by spironolactone (p<0.05). Increased iNOS and IFN-α mRNA gene expression (M1 macrophage markers) was observed in aldosterone + salt rats, whereas no significant differences were observed in IL- 10 and gene ArgI mRNA expression or ED2 protein content (M2 macrophage markers). All the observed changes were blocked with spironolactone treatment. Macrophage depletion with liposomal clodronate reduced macrophage influx and inflammatory M1 markers (INF- or iNOS), whereas interstitial fibrosis was only partially reduced after this intervention, in aldosterone plus salt-treated rats. In conclusion, aldosterone + salt administration mediates inflammatory M1 macrophage phenotype and increased fibrosis throughout mineralocorticoid receptors activation. © 2016 2016 Martín-Fernández et a.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Source