University Analytical Center

Welton, United Kingdom

University Analytical Center

Welton, United Kingdom

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Elbagerma M.A.,University Analytical Center | Edwards H.G.M.,University Analytical Center | Azimi G.,Arak University | Scowen I.J.,University Analytical Center
Journal of Raman Spectroscopy | Year: 2011

A sensitive and efficient method for the determination of acidity constants of salicylaldoxime (SALO) (2-hydroxybenzaldehyde oxime), using both Raman spectroscopic and potentiometric methods, at 30 °C in 50% (wt/wt) of ethanol-water mixture and at the constant ionic strength I = 0.1 M is proposed. The effect of pH on the Raman spectra has also been studied. The Raman spectroscopic technique allows the identification of compounds in different molecular and molecular ionic structures. The limit of detection (LOD) was determined to be 0.05 mol dm-3 for SALO by means of Raman peak area. © 2010 John Wiley & Sons, Ltd.


Elbagerma M.A.,University Analytical Center | Azimi G.,Arak University | Edwards H.G.M.,University Analytical Center | Alajtal A.I.,University Analytical Center | Scowen I.J.,University Analytical Center
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2010

Molecular speciation of organic compounds in solution is essential for the understanding of ionic complexation. The Raman technique was chosen because it allows the identification of compounds in different states, and it can give information about the molecular geometry from the analysis of the vibrational spectra. The effect of pH on organic compounds can give information about the ionisation of molecule species. In this study the ionisation steps of salicylic acid and paracetamol have been studied by means of potentiometry coupled with Raman spectroscopy at 30.0 °C in a solution of ionic strength 0.96 mol dm -3 (KNO 3) and 0.04 mol dm -3 (HNO 3). The protonation and deprotonation behaviour of the molecules were studied in different pH regions. The abundance of the three different species in the Raman spectra of aqueous salicylic acid have been identified satisfactorily, characterised, and determined by numeric treatment of the data using a multiwavelength curve-fitting program and confirmed with the observed spectral information. © 2010 Elsevier B.V. All rights reserved.

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