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Rosso G.,University of Turin | Cattaneo A.,Irccs Centro S Giovanni Of Dio | Cattaneo A.,King's College London | Zanardini R.,Irccs Centro S Giovanni Of Dio | And 5 more authors.
Journal of Affective Disorders | Year: 2015

Patients with bipolar disorder (BD) are more frequently affected by metabolic syndrome (MetS) than the general population, but the neurobiological correlates underlying such association are still not clarified and few studies in BD have evaluated the role of regulators of lipid and glucose metabolism. The present study was aimed to investigate putative alterations in markers linked to metabolic dysfunctions as C-peptide, Ghrelin, GIP, GLP-1, Glucagon, Insulin, Leptin, PAI-1 (total), Resistin and Visfatin in a sample of BD patients compared to controls. Furthermore, associations between changes of metabolic markers and relevant clinical features, such as severity of symptomatology, number and type of past mood episodes, drug treatments and presence/absence of metabolic alterations (MetS, diabetes and cardiovascular disease) were analyzed. A total of 57 patients with BD and 49 healthy controls were recruited. The main results showed lower serum levels of Glucagon, GLP-1, Ghrelin, and higher levels of GIP in BD patients as compared to controls (p=0.018 for Ghrelin; p<0.0001 for Glucagon; p<0.0001 for GLP-1; p<0.0001 for GIP). Further, Glucagon and GLP-1 levels were significantly associated with the number of past mood episodes. These findings support the hypothesis that alterations in Glucagon, GLP-1, GIP and Ghrelin might be involved in BD pathogenesis and might represent useful biomarkers for the development of preventive and personalized therapies in this disorder. © 2015 Published by Elsevier B.V.


Bonomi S.,ampus University | Zardini A.,University of Verona | Rossignoli C.,University of Verona | Renata Dameri P.,University of Genoa
Lecture Notes in Business Information Processing | Year: 2015

The objective of the paper is to study the use of service science to create a systematic service innovation in the health environment. Starting from the basic abstraction of service science, which is considered as value co-creation when people, technology and value propositions are connected by internal and external service systems and shared information [1], the paper aims to explain the benefits of the electronic medical record (EMR) and its business and organizational impacts in an Italian Academic Integrated Hospital. The research method is based on a case study and on connected semi-structured interviews. The qualitative study shows the co-created value, i.e. the impacts of introduction and development (consolidation) of EMR on efficacy and efficiency of the organization, on data collection and processing, error reduction, sustainability of SSN (national health service) and especially the better quality of services to the citizens. © Springer International Publishing Switzerland 2015.


D'Andrea E.,University of Pisa | Ducange P.,ampus University | Lazzerini B.,University of Pisa | Marcelloni F.,University of Pisa
IEEE Transactions on Intelligent Transportation Systems | Year: 2015

Social networks have been recently employed as a source of information for event detection, with particular reference to road traffic congestion and car accidents. In this paper, we present a real-time monitoring system for traffic event detection from Twitter stream analysis. The system fetches tweets from Twitter according to several search criteria; processes tweets, by applying text mining techniques; and finally performs the classification of tweets. The aim is to assign the appropriate class label to each tweet, as related to a traffic event or not. The traffic detection system was employed for real-time monitoring of several areas of the Italian road network, allowing for detection of traffic events almost in real time, often before online traffic news web sites. We employed the support vector machine as a classification model, and we achieved an accuracy value of 95.75% by solving a binary classification problem (traffic versus nontraffic tweets). We were also able to discriminate if traffic is caused by an external event or not, by solving a multiclass classification problem and obtaining an accuracy value of 88.89%. © 2000-2011 IEEE.


Palpacelli M.,Marche Polytechnic University | Carbonari L.,Marche Polytechnic University | Palmieri G.,ampus University
MESA 2014 - 10th IEEE/ASME International Conference on Mechatronic and Embedded Systems and Applications, Conference Proceedings | Year: 2014

The paper proposes the mechanical design of a lockable spherical joint, which is designed to be manually or automatically configured in different kinematic solutions. In fact it can be used as a conventional spherical joint or converted in a universal joint or still downgraded to a revolute joint. Therefore different configurations can be chosen according to user needs. In particular, two of the three axes of revolution, arranged in the typical roll-pitch-roll sequence of robot spherical wrists, can be locked alternatively in order to provide two differently arranged U-joints. It can be demonstrated that such behavior allows to activate different mobilities of two classes of reconfigurable parallel kinematics manipulators. The transition between such mobilities occurs exploiting the concept of over-constrained kinematics, which is realized by the lockable joint during the switching phase in order to avoid an instantaneous mobility of the robot. © 2014 IEEE.


Palpacelli M.,Marche Polytechnic University | Callegari M.,Marche Polytechnic University | Carbonari L.,Italian Institute of Technology | Palmieri G.,ampus University
Proceedings of the ASME Design Engineering Technical Conference | Year: 2015

This paper presents the design of a reconfigurable parallel kinematics machine endowed with three degrees of freedom of pure translation, or alternately of pure rotation. Such reconfigurability results from the use of lockable spherical joints, which realize the connection between each robot leg and the moving platform. Three actuated legs are used to drive the platform motion. The change of configuration occurs only at a specific pose, called home configuration. A control strategy allows to manage the shift phase and activate the two mobilities one at a time. Multibody simulations allowed to analyze the dynamic behavior of the manipulator and to verify the choices made with regard to the robot mechanics and the size of actuation systems. Position and differential kinematics of the manipulator are briefly introduced in order to demonstrate the simplicity of the analytic expressions and the mechanical feasibility of the manipulator. © Copyright 2015 by ASME.


Corinaldi D.,Marche Polytechnic University | Callegari M.,Marche Polytechnic University | Palpacelli M.-C.,Marche Polytechnic University | Palmieri G.,ampus University
Proceedings of the ASME Design Engineering Technical Conference | Year: 2015

The paper presents the preliminary design of a novel gripper able to grasp large non-rigid materials that has been conceived to face the challenge of automatic handling tasks in the leather industry. The design has been driven by the requirements to limit production costs and the complexity of the grasping device. A statistical analysis of the different templates sizes has allowed to identify a fixed configuration of the gripping points able to properly pick all the sheets within a great confidence interval. According to the varying shape of the leather templates themselves, that is due to their stacking in plies on the beam, the trajectory of the gripping points has been studied and arranged. Due to the irregular shape of the large sheets that are handled, the edges of the non-rigid materials out of the gripping area might flutter during the transferring phase: A four-bar linkage has been specifically designed, so that the motion of its end-effector prevents unwanted leather creases. © Copyright 2015 by ASME.


Palpacelli M.,Marche Polytechnic University | Palmieri G.,ampus University | Carbonari L.,Marche Polytechnic University | Callegari M.,Marche Polytechnic University
Advanced Robotics | Year: 2014

The present paper addresses the modelling and the experimental identification of the static behaviour of the Tricept robot, a hybrid parallel kinematic machine. Mass properties of robot links are initially hypothesized from solid modelling and then incorporated in the identification procedure. Coulomb friction and gravity contributions to motor torques are taken into account: their identification is carried out by means of ordinary least-squares algorithms based on motor currents measurements during several slow motion tests. Moreover, the effect of external forces applied at the end-effector is introduced in the model and analysed by driving the robot end-effector against a calibrated compliant cell. Eventually, the static model is profitably used in an industrial operation of Friction Stir Welding to estimate the external forces applied at the tool mechanical interface providing some benefits: a deeper understanding of the technological process parameters and the possibility to realize model-based controls. © 2014 Taylor & Francis and The Robotics Society of Japan.


Battilotti S.,University of Rome La Sapienza | Delli Priscoli F.,University of Rome La Sapienza | Gori Giorgi C.,University of Rome La Sapienza | Monaco S.,University of Rome La Sapienza | And 4 more authors.
Chinese Control Conference, CCC | Year: 2015

In the perspective of the emerging Future Internet framework, the Quality of Experience (QoE) Control functionalities are aimed at approaching the desired QoE level of the applications by dynamically selecting the most appropriate Classes of Service supported by the network. In the present work, this selection is driven by Multi-Agent Reinforcement Learning, namely by the Friend-Q learning algorithm. The proposed dynamic approach differs from the traffic classification approaches found in the literature, where a static assignment of Classes of Service to application instances is performed. All these improvements are aimed at adding a cognition loop to telecommunication networks, by making use of Multi-Agent Reinforcement Learning, and at fostering the intelligent connectivity between applications and networks. © 2015 Technical Committee on Control Theory, Chinese Association of Automation.


Palpacelli M.-C.,Marche Polytechnic University | Palmieri G.,ampus University | Callegari M.,Marche Polytechnic University
Journal of Mechanisms and Robotics | Year: 2012

This article presents the concept of a novel parallel kinematics manipulator (PKM) designed for miniature scale applications. A flexible universal joint made of superelastic material provides the device two rotational degrees of freedom, which are redundantly driven by three linear actuators that push against the mobile platform with a sphere-plane unilateral constraint. The kinematic and structural behavior of the flexible joint and the overall kinetostatic performance of the manipulator are investigated. Eventually a preliminary design is proposed, aimed at creating a physical prototype of the machine. © 2012 American Society of Mechanical Engineers.


Palpacelli M.-C.,Marche Polytechnic University | Carbonari L.,Marche Polytechnic University | Palmieri G.,ampus University | Callegari M.,Marche Polytechnic University
IEEE/ASME Transactions on Mechatronics | Year: 2015

This paper presents the design of a reconfigurable 3-DoF parallel kinematics manipulator. The main feature of the device is the ability to change the mobility of its moving platform from pure translation to pure rotation. The manipulator kinematics is conceived so that, when a particular configuration of the manipulator is reached, the transition between the two working modes is possible by changing the configuration of a metamorphic universal joint, which is used to connect the legs of the manipulator with the moving platform. The mechanical design of the joint, which is in fact a lockable spherical joint, is illustrated. With the joint integrated into therobot architecture, an instantaneous overconstrained kinematics is exploited to manage the phase of reconfiguration of the whole mechatronic device. A kineto-static analysis provides information about the influence of geometric parameters on its functional design. The manipulator shows simple kinematics and statics models, as well as good kinematic and static performances. Eventually, the versatility of the manipulator is shown by proposing some advanced manufacturing applications in which it could find use. © 1996-2012 IEEE.

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