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Russo G.T.,Universito Degli Studi Of Messina | Romeo E.L.,Universito Degli Studi Of Messina | Giandalia A.,Universito Degli Studi Of Messina | Forte F.,Universito Degli Studi Of Messina | Cucinotta D.,Universito Degli Studi Of Messina
Giornale Italiano di Diabetologia e Metabolismo | Year: 2014

β-cell dysfunction is one of the main mechanisms in the patho-genesis of type 2 diabetes, often already detectable in the early stages of the disease. Impaired insulin secretion and cell loss can both lead to β-cell dysfunction, and several mechanisms appear to contribute. Factors such as inflammation, oxidative stress, amyloid plaques, and endoplasmic reticulum stress are all involved in β-cell failure and result from gene-environment interactions.Preservation of β-cell function should be a goal of type 2 diabetes treatment, and some of the diabetes medications available today could play a protective role on this function. © 2014 UTET Periodici Scientifici srl.All rights reserved.

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