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Yu H.-C.,Universities for Food Safety and Pharmaceutical Analytical Chemistry | Yu H.-C.,Guangxi University for Nationalities | Huang X.-Y.,Universities for Food Safety and Pharmaceutical Analytical Chemistry | Huang X.-Y.,Guangxi University for Nationalities | And 9 more authors.
Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica | Year: 2014

To improve the sensitivity of molecular imprinted electrochemical sensors, a molecularly imprinted polymer (MIP) film for the determination of phenobarbital (PB) was electropolymerized on a CuO nanoparticlemodified glassy carbon electrode. Methacrylic acid was used as the functional monomer and ethylene glycol maleic rosinate acrylate as a cross-linking agent in the presence of supporting electrolyte (tetrabutylammonium perchlorate). The electrochemical properties of CuO nanoparticle-modified molecularly imprinted and non- imprinted polymer (NIP) sensors were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The results showed that the electrochemical properties of the CuO nanoparticle-modified MIP sensor were completely different from those of NIP sensors. X-ray diffraction confirmed that the nanoparticles were CuO. The morphology of the CuO nanoparticle-modified MIP sensor was examined under a scanning electron microscope. The CuO nanoparticles were uniformly distributed on the surface of the modified glassy carbon electrode, which improved the recognition sites of the modified MIP sensor. The response value of the DPV peak current showed linear dependence on the PB concentration in the range 1.0×10-8 to 1.8×10-4 mol∙L-1 (linear regression coefficient =0.9994) with a detection limit (S/N=3) of 2.3×10-9 mol∙L-1. The results indicated that the CuO nanoparticle-modified MIP sensor is one of the most sensitive and selective sensors for PB determination. The prepared sensor was successfully applied for the determination of PB in practical samples and the recovery ranged from 95.0% to 102.5%. © 2014, Editorial office of Acta Physico-Chimica Sinica. Source

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