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Murviel-lès-Montpellier, France

The aim of this study was to expand our knowledge of the influence of emotional valence on visual word recognition by answering two questions. The first was to examine whether the emotional valence effect is sensitive to different types of task requirements, and the second was to examine whether words polysemy can modulate the effect of emotional valence. For this purpose, we manipulated orthogonally emotional valence (negative, positive and neutral words) and polysemy (polysemous vs. non polysemous words) in two versions of the lexical-decision task (one with legal nonwords and one with illegal nonwords). Results showed an effect of task: emotional valence and polysemy influenced lexical decision latencies only in the legal version of the lexical-decision task. Furthermore, results showed that the effect of polysemy was dependant on emotional valence. We observed a facilitation of polysemy for neutral words but not for emotional ones. Finally this experiment also showed that polysemy modulates the emotional valence effect. The facilitation observed for non polysemous emotional words compared to non polysemous neutral words disappeared for polysemous words. These findings fit with other studies showing facilitation for emotional word recognition and allow conclusions concerning the role of semantics on emotional word recognition. © 2012 Canadian Psychological Association.

Schwartz A.,CNRS Center for Molecular Biophysics | Rabhi M.,CNRS Center for Molecular Biophysics | Rabhi M.,University of Orleans | Margeat E.,French National Center for Scientific Research | And 3 more authors.
Methods in Enzymology | Year: 2012

Nucleotide analog interference mapping (NAIM) is a combinatorial approach that probes individual atoms and functional groups in an RNA molecule and identifies those that are important for a specific biochemical function. Here, we show how NAIM can be adapted to reveal functionally important atoms and groups on RNA substrates of helicases. We explain how NAIM can be used to investigate translocation and unwinding mechanisms of helicases and discuss the advantages and limitations of this powerful chemogenetic approach. © 2012 Elsevier Inc. All rights reserved.

Bayard S.,Service de Neurologie | Bayard S.,French Institute of Health and Medical Research | Langenier M.C.,Service de Neurologie | Langenier M.C.,Universites Montpellier | And 2 more authors.
Sleep | Year: 2013

Objective: To investigate the effect of psychostimulants on impulsivity, depressive symptoms, addiction, pathological gambling, and risk-taking using objective sensitivity tests in narcolepsy with cataplexy (NC). Drug-free patients with NC present alterations in reward processing, but changes with psychostimulants remain unknown. Design: Prospective case-control study. Setting: Academic sleep disorders center. Participants: There were 120 participants: 41 drug-free patients with NC, 37 patients with NC taking psychostimulants, and 42 matched healthy controls. Interventions: All participants underwent a semistructured clinical interview for impulse control and addictive behaviors and completed questionnaires for depression and impulsivity. Risk taking was analyzed through performance on a decision-making task under ambiguity (Iowa Gambling Task [IGT]) and under risk (Game of Dice Task [GDT]). All patients with NC underwent 1 night of polysomnography followed by a multiple sleep latency test for drug-free patients and a maintenance wakefulness test for treated patients. Results: Depressive symptoms were higher in drug-free patients than in treated patients and controls, with no difference between controls and treated patients. No between-group differences were found for impulsivity, substance addiction, or pathological gambling. Drug-free and treated patients showed selective reduced performance on the IGT and normal performance on the GDT compared with controls, with no differences between patients taking medication and those who did not. No clinical or polysomnographic characteristics or medication type was associated with IGT scores. Conclusions: Our results demonstrated that, whether taking psychostimulants or not, patients with narcolepsy with cataplexy preferred risky choices on a decision-making task under ambiguity. However, the lack of association with impulsivity, pathological gambling, or substance addiction remains of major clinical interest in narcolepsy with cataplexy. © 2013 Associated Professional Sleep Societies, LLC.

Ninot G.,Universites Montpellier
Revue des Maladies Respiratoires | Year: 2011

COPD does not only affect the respiratory function of a patient. It also affects his/her cognitive and affective functions. These effects can be seen particularly in the incidence of anxiety and depressive disorders at different periods during the stage of the illness. This review of the literature suggests some contemporary definitions of these disorders, their link to COPD, and procedures for their assessment during clinical practice. © 2011 SPLF. Published by Elsevier Masson SAS. All rights reserved.

Bayard S.,Montpellier University | Dauvilliers Y.,Unite des Troubles du Sommeil | Dauvilliers Y.,French Institute of Health and Medical Research | Yu H.,Fudan University | And 7 more authors.
Parkinsonism and Related Disorders | Year: 2014

Introduction: The relationship between ICD and RBD is still not yet understood and the results from the current literature are contradictory in PD. We aimed to explore the association between rapid eye movement (REM) sleep behavior disorder (RBD) and impulse control disorder in Parkinson's disease. Methods: Ninety-eight non-demented patients with Parkinson's disease underwent one night of video-polysomnography recording. The diagnosis of RBD was established according to clinical and polysomnographic criteria. Impulse control disorders were determined by a gold standard, semi-structured diagnostic interview. Results: Half of the patients (n=49) reported clinical history of RBD while polysomnographic diagnosis of RBD was confirmed in 31.6% of the patients (n=31). At least one impulse control disorder was identified in 21.4% of patients, 22.6% with RBD and 20.9% without. Logistic regression controlling for potential confounders indicated that both clinical RBD (OR=0.34, 95% CI=0.07-1.48, P=0.15) and polysomnographic confirmed RBD diagnoses (OR=0.1.28, 95% CI=0.31-5.33, P=0.34) were not associated with impulse control disorder. Conclusion: In Parkinson's disease, REM Sleep Behavior Disorder is not associated with impulse control disorder. The results of our study do not support the notion that PSG-confirmed RBD and ICD share a common pathophysiology. © 2014 Elsevier Ltd.

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