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Sherbrooke, Canada

The Université de Sherbrooke is a large university in Quebec, Canada with campuses located in Sherbrooke and Longueuil, a suburb of Montreal approximately 130 km west of Sherbrooke. It is one of two universities, and the only French language university, in the Estrie region of Quebec.In 2007, the Université de Sherbrooke was home to 35,000 students and a teaching staff of 3,200. In all, it employs 6,400 people. The university has over 100,000 graduates and offers 46 undergraduate, 48 Master's and 27 doctoral programs. It holds a total of 61 research chairs, among which are the pharmacology, microelectronics, statistical learning, and environment research chairs. Wikipedia.

Gohy J.-F.,Catholic University of Louvain | Zhao Y.,Universite de Sherbrooke
Chemical Society Reviews | Year: 2013

Stimuli-responsive block copolymer micelles are the topic of intense research since they are able to show sharp and eventually reversible responses to various environmental changes and find applications in various fields including controlled drug delivery. Among all the available stimuli, light has recently attracted much attention since it can be localized in time and space, and it can also be triggered from outside of the system. In this tutorial review, we highlight the progress realized in recent years. More precisely, we provide some guidelines towards the rational design of photo-responsive block copolymers and we present the different photo-responsive moieties that have been used so far. We also discuss the different types of irreversible and reversible responses encountered by photo-responsive block copolymer micelles. Finally, we suggest possible future developments including the design of biocompatible systems operating at excitation wavelengths compatible for biomedical applications. © 2013 The Royal Society of Chemistry.

Zhao Y.,Universite de Sherbrooke
Macromolecules | Year: 2012

The association state of light-responsive block copolymer (BCP) micelles in aqueous solution can be altered, often reversibly, by light. Driven by the potential application in controlled drug delivery, this type of stimuli-responsive polymer micelles has received increasing attention. This Perspective highlights the progress achieved in recent years. On the one hand, we discuss the different approaches of rational BCP design, making use of various photochromic moieties and photochemical reactions, and the underlying mechanisms leading to photoinduced disruption of BCP micelles. On the other hand, we suggest possible future directions in this area, including exploration of new mechanisms and chemistry and solutions to the excitation wavelength problem crucial for biomedical applications. © 2012 American Chemical Society.

Taillefer L.,Universite de Sherbrooke
Annual Review of Condensed Matter Physics | Year: 2010

The origin of the exceptionally strong superconductivity of cuprates remains a subject of debate after more than two decades of investigation. Here we follow a new lead: The onset temperature for superconductivity scales with the strength of the anomalous normal-state scattering that makes the resistivity linear in temperature. The same correlation between linear resistivity and T c is found in organic superconductors, for which pairing is known to come from fluctuations of a nearby antiferromagnetic phase, and in pnictide superconductors, for which an antiferromagnetic scenario is also likely. In the cuprates, the question is whether the pseudogap phase plays the corresponding role, with its fluctuations responsible for pairing and scattering. We review recent studies that shed light on this phase - its boundary, its quantum critical point, and its broken symmetries. The emerging picture is that of a phase with spin-density-wave order and fluctuations, in broad analogy with organic, pnictide, and heavy-fermion superconductors. Copyright © 2010 by Annual Reviews. All rights reserved.

Gonzalez-Lamothe R.,Universite de Sherbrooke
The Plant cell | Year: 2012

Auxin is a pivotal plant hormone that regulates many aspects of plant growth and development. Auxin signaling is also known to promote plant disease caused by plant pathogens. However, the mechanism by which this hormone confers susceptibility to pathogens is not well understood. Here, we present evidence that fungal and bacterial plant pathogens hijack the host auxin metabolism in Arabidopsis thaliana, leading to the accumulation of a conjugated form of the hormone, indole-3-acetic acid (IAA)-Asp, to promote disease development. We also show that IAA-Asp increases pathogen progression in the plant by regulating the transcription of virulence genes. These data highlight a novel mechanism to promote plant susceptibility to pathogens through auxin conjugation.

Frigon A.,Universite de Sherbrooke
Neuroscientist | Year: 2012

Neuronal networks within the spinal cord of mammals are responsible for generating various rhythmic movements, such as walking, running, swimming, and scratching. The ability to generate multiple rhythmic movements highlights the complexity and flexibility of the mammalian spinal circuitry. The present review describes features of some rhythmic motor behaviors generated by the mammalian spinal cord and discusses how the spinal circuitry is able to produce different rhythmic movements with their own sets of goals and demands. © SAGE Publications 2012.

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