Simonato S.,Karlsruhe Institute of Technology |
Groger H.,Karlsruhe Institute of Technology |
Mollmer J.,Institute fur Nichtklassische Chemie E.V. Permoser |
Mollmer J.,Offenburg University of Applied Sciences |
And 5 more authors.
Chemical Communications | Year: 2012
The CO 2 uptake on nanoscale AlO(OH) hollow spheres (260 mg g -1) as a new material is comparable to that on many metal-organic frameworks although their specific surface area is much lower (530 m 2 g -1versus 1500-6000 m 2 g -1). Suited temperature-pressure cycles allow for reversible storage and separation of CO 2 while the CO 2 uptake is 4.3-times higher as compared to N 2.
Garmer M.,Universitatsstrasse 142 |
Busch M.,Universitatsstrasse 142 |
Mateiescu S.,Universitatsstrasse 142 |
Fahlbusch D.E.,Witten/Herdecke University |
And 2 more authors.
Academic Radiology | Year: 2015
Rationale and Objectives: Accuracy of ultrasound-guided biopsy and Gleason score is limited, and diagnosis of insignificant cancer with Gleason score ≤6 is frequent when extended biopsy schemes are used. We evaluated whether the magnetic resonance imaging (MRI)-targeted in-bore prostate biopsy correctly identifies the Gleason score of prostate cancer in histopathologic correlation after prostatectomy. Simultaneously a targeted concept is expected to keep down the rate of insignificant cancer. Materials and Methods: We compared retrospectively the Gleason score of the MRI-targeted in-bore biopsy with prostatectomy specimens in 50 men with prostate cancer. Endorectal MRI included T2-weighted imaging, diffusion-weighted imaging, dynamic contrast-enhanced imaging, and spectroscopy. Lesions with a prostate imaging-reporting and data system (PI-RADS) score ≥3 were considered. Upgrading and downgrading of tumors was evaluated, and significant upgrading was defined as a shift in Gleason score from 6 to 7 or more. Results: Gleason score was concordant in 66% of the patients, overall upgraded in 30% of patients, and downgraded in 4% of patients. Significant upgrading of the Gleason score from 6 to 7 occurred in eight patients; upgrading did not exceed one step in the Gleason score. After prostatectomy the Gleason score 6 was found in 20% of patients. The median number of cores obtained was 4 (range 2-6), and the median number of positive cores was 2 (range 1-4). Conclusions: In-bore MRI-targeted biopsy offers good accuracy in the Gleason score with postprostatectomy histopathologic control when compared to the literature. A limited number of cores are sufficient to achieve these results. The fraction of insignificant cancer identified by targeted only-biopsy is low. Upgrading is restricted to one step in the Gleason score. Clinicians should be aware of positive findings in MRI and the biopsy technique used when assessing prostate biopsy results. © 2015 AUR.
Beckers R.,Universitatsstrasse 142
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Year: 2015
Numerous telemedical projects have not been managed to widen itself. The federal states have sponsored many projects in the past. The central question therefore is, if projects can be spread everywhere. To answer this question, at first the initiatives of the federal states are introduced very briefly. Important aspects are then defined for a nationwide behaviour. Important aspects are then defined. ln the result it turns out that the federal states play an indispensable role for telemedicine. © 2015, Springer-Verlag Berlin Heidelberg.
From the project to standard care: The correct assessment of the benefits of telemedicine has a key role [Vom Projekt zur Regelversorgung: Die richtige Bewertung des Nutzens der Telemedizin hat eine Schlüsselrolle]
Beckers R.,Universitatsstrasse 142 |
Strotbaum V.,Universitatsstrasse 142
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Year: 2015
The reason for this contribution is the hesitant dissemination of telemedicine procedures in the healthcare system. Because of missing benefits there are few incentives for players to use telemedicine procedures in the interest of patients. It is the aim of the work to open a discussion that differentiates the framework for the benefit assessment of telemedicine along certain criteria. The intention is to create a tool that helps to speed up necessary decisions in the committees responsible. This work develops a new categorization for telemedicine applications by differentiating between the medical model and the technical process of telemedicine application. The categories refer to the medical and economic risk level of the applications. Only applications with highest risk must, therefore, be evaluated by RCT surveys. © 2015, Springer-Verlag Berlin Heidelberg.
Application of the holistic observation method on shield tunnel drives as a means of preventing disputes and conflict reduction in case of interruptions [Anwendung der ganzheitlichen Beobachtungsmethode bei Schildvortrieben als Mittel zur präventiven Streitvermeidung und Konfliktreduzierung bei Störsituationen]
Handke D.,Universitatsstrasse 142
Geomechanik und Tunnelbau | Year: 2014
The consistent application of the observation method on shield tunnel drives can make a considerable contribution to preventative dispute avoidance and conflict reduction when issues occur. The observation method should include not only the monitoring and analysis of mechanical process data such as machine data, control parameters and data from the geotechnical instrumentation but also process control as the tunnel advances, which is documented in the following quality assurance documents: explanatory report, machine concept, incident analysis, specification, tunnelling machine handbook and the tunnelling plan before tunnelling and report after completion. This should be interpreted as a unit and is defined as the holistic observation method. © 2014 Ernst & Sohn Verlag für Architektur und technische Wissenschaften GmbH & Co. KG, Berlin.
Herrmann B.L.,University of Duisburg - Essen |
Herrmann B.L.,Universitatsstrasse 142 |
Schmid K.W.,University of Duisburg - Essen |
Goerges R.,University of Duisburg - Essen |
And 2 more authors.
European Journal of Endocrinology | Year: 2010
Context: Serum calcitonin (hCT) measurement may be useful for detecting medullary thyroid carcinoma (MTC), but the routine use of hCT after pentagastrin stimulation to screen patients with nodular thyroid disease remains controversial. Patients: A total of 1007 patients (567 females and 440 males) with nodular thyroid disease and a mean age of 55±14 (mean±S.D.) years were included in the study. All patients did not have impaired renal function, bacterial infection, alcohol and drug abuse, pseudohypoparathyroidism, or proton-pump inhibitor therapy. Individuals referred with known elevation of hCT, Graves' disease, or autoimmune thyroid disease were not considered or included in this investigation. Methods: Serum hCT levels were determined under basal conditions, and when basal values were ≥ 10 and < 100 pg/ml, testing was repeated after pentagastrin stimulation. Patients with basal or stimulated levels > 100 pg/ml were referred for surgery. Results: hCT levels > 10 pg/ml were increased in 17 patients (1.7%). One patient had a basal hCT level of 4400 pg/ml with a histological confirmation of a MTC. In this patient, pentagastrin test was not performed. Sixteen patients with basal hCT between 10 and 100 pg/ml underwent pentagastrin-stimulated hCT measurement. Of 16 patients, 4 had stimulated hCT> 100 pg/ml. Of 17 patients with hCT> 10 pg/ml, 2 had MTC, and of 17 patients, 3 had C-cell hyperplasia. In total, two patients (0.20%) had a histologically verified MTC. Conclusions: Basal hCT measurement together with pentagastrin-stimulated hCT measurement in cases of basal hCT> 10 pg/ml detects MTC in 0.20% of patients with nodular thyroid disease.Whether this high incidence of MTC has major implications or not has to be discussed, but it should be considered as a useful and recommended tool for early detection of MTC and to save patients' life. © 2010 European Society of Endocrinology.
Chowdhury P.,Indian Institute of Technology Guwahati |
Mekala S.,Indian Institute of Technology Guwahati |
Dreisbach F.,Universitatsstrasse 142 |
Gumma S.,Indian Institute of Technology Guwahati
Microporous and Mesoporous Materials | Year: 2012
A comparative adsorption study of three gases viz. CO, CO 2 and CH 4 on two adsorbents viz. Cu-BTC (or HKUST-1) and Cr-BDC (or MIL-101) is reported in this article. The gravimetric adsorption equilibrium measurements on the samples were performed in a Rubotherm magnetic suspension balance at three different temperatures: 295, 318 and 353 K and pressures ranging between 0 and 100 bar. Virial-Langmuir model was used to model the experimental data on Cu-BTC, whereas Dual Site Langmuir (DSL) model was used for adsorption on MIL-101. For all gases the enthalpy of adsorption at low loading was higher on MIL-101 than that on Cu-BTC, indicating the availability of open metal sites in case of MIL-101. Moreover, a sharp decrease in enthalpy of adsorption is observed in case of MIL-101, whereas only a moderate decrease is observed in case of Cu-BTC. CO has a large Henry's constant on MIL-101, whereas at higher pressures, the solid exhibits better capacity for CO 2. In case of Cu-BTC, CO 2 has a higher capacity on the adsorbent as compared to the other two gases throughout the entire range of pressures studied. All the experimental data is critically analyzed by examining the role of open metal centers, adsorbate polarity and the effect of temperature on the electrostatic interactions. © 2011 Elsevier Inc. All rights reserved.
Quality and risk management strategy for mechanized tunnelling – From machine concept to process controlling / Qualitätssicherungselemente und Risikomanagementstrategie für den maschinellen Tunnelbau – Vom Maschinenkonzept zum Prozesscontrolling
Handke D.,Universitatsstrasse 142 |
Edelhoff D.,Universitatsstrasse 142
Geomechanik und Tunnelbau | Year: 2016
Mechanized tunnelling is a highly technical construction process, which requires the establishment of precise objectives to consistently guarantee high quality and safety standards while still considering the aspects of time and cost reduction. In the tendering and construction phases, these objectives can be met by the application of a risk management strategy and the integration of quality assurance elements. The implementation of process controlling with the objectives optimization, error prevention and documentation provides a centralized monitoring element in the construction phase. External experts can monitor tunnelling activities in real time and submit recommendations in case of deviations. With downstream analyses, incidents can be evaluated and methodological errors identified. Der maschinelle Tunnelbau ist ein hoch mechanisiertes Bauverfahren, bei dem zur Sicherstellung einer dauerhaft hohen Qualität und Einhaltung höchster Sicherheitsstandards bei gleichzeitiger Berücksichtigung bauzeit- und kostenreduzierender Aspekte klare Zielformulierungen aufgestellt werden müssen. In der Ausschreibungs- und Ausführungsphase können diese Zielstellungen durch die Anwendung einer Risikomanagementstrategie und die Integration von Qualitätssicherungselementen erfüllt werden. Die Ausführung eines Prozesscontrollings mit der Zielstellung Optimierung, Fehlervermeidung und Dokumentation stellt ein zentrales Überwachungselement in der Bauphase dar. Hierbei werden von externen Experten die Vortriebsarbeiten in Echtzeit überwacht und bei Vorliegen von Abweichungen Handlungsempfehlungen unterbreitet. Über nachgeschaltete Analysen können Schadensereignisse bewertet und Verfahrensfehler identifiziert werden. © 2016 Ernst & Sohn Verlag für Architektur und technische Wissenschaften GmbH & Co. KG, Berlin
Fieback T.M.,Ruhr University Bochum |
Dreisbach F.,Universitatsstrasse 142
Industrial and Engineering Chemistry Research | Year: 2011
For sorption measurements many different methods are applicable, but nearly all of them require a correction of the raw experimental data by a factor including the sample's volume. This can be determined by a separate volume measurement for samples with constant volumes. If the sample volume is not constant because of swelling effects, the actual volume is usually calculated by suitable equations of state (EOS) for the sample-gas-system (if available) or estimated by optical or spectroscopic sample observation and assumptions about orientation of swelling. The advantage of the new approach presented here is that one measurement leads to both unknown quantities: sample volume and absorption. Not only is the volume measurement for constant sample volumes is obsolete, also the actual volume of swollen samples can be determined with minimal effort. The method can be applied to liquid and solid state samples without optical or spectroscopic sample observation or any assumption about orientation of swelling. © 2011 American Chemical Society.
Nebel M.,Ruhr University Bochum |
Eckhard K.,Ruhr University Bochum |
Erichsen T.,Universitatsstrasse 142 |
Schulte A.,Suranaree University of Technology |
Schuhmann W.,Ruhr University Bochum
Analytical Chemistry | Year: 2010
4D shearforce-based constant-distance mode scanning electrochemical microscopy (4D SF/CD-SECM) is designed to assess SECM tip currents at several but constant distances to the sample topography at each point of the x,y-scanning grid. The distance dependent signal is achieved by a shearforce interaction between the in-resonance vibrating SECM tip and the sample surface. A 4D SF/CD-SECM measuring cycle at each grid point involves a shearforce controlled SECM tip z-approach to a point of closest distance and subsequent stepwise tip retractions. At the point of closest approach and during the retraction steps, pairs of tip current (I) and position are acquired for various distances above the sample surface. Such a sequence provides x,y,I maps, that can be compiled and displayed for each selected data acquisition distance. Thus, multiple SECM images are obtained at known and constant distances above the sample topography. 4D SF/CD-SECM supports distance-controlled tip operation while continuous scanning of the SECM tip in the shear-force distance is avoided. In this way, constant-distance mode SECM imaging can be performed at user-defined, large tip-to-sample distances. The feasibility and the potential of the proposed 4D SF/CD-SECM imaging is demonstrated using on the one hand amperometric feedback mode imaging of a Pt band electrode array and on the other hand the visualization of the diffusion zone of a redox active species above a microelectrode in a generator/collector arrangement. © 2010 American Chemical Society.