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Mainz, Germany

Goetz M.,Universitatsmedizin Mainz | Wang T.D.,University of Michigan
Gastroenterology | Year: 2010

Molecular imaging is a rapidly growing new discipline in gastrointestinal endoscopy. It uses the molecular signature of cells for minimally-invasive, targeted imaging of gastrointestinal pathologies. Molecular imaging comprises wide field techniques for the detection of lesions and microscopic techniques for in vivo characterization. Exogenous fluorescent agents serve as molecular beacons and include labeled peptides and antibodies, and probes with tumor-specific activation. Most applications have aimed at improving the detection of gastrointestinal neoplasia with either prototype fluorescence endoscopy or confocal endomicroscopy, and first studies have translated encouraging results from rodent and tissue models to endoscopy in humans. Even with the limitations of the currently used approaches, molecular imaging has the potential to greatly impact on future endoscopy in gastroenterology. © 2010 AGA Institute. Source


Hoffmann E.M.,Universitatsmedizin Mainz
Klinische Monatsblatter fur Augenheilkunde | Year: 2012

Optical coherence tomography (OCT) provides high resolution objective and quantitative measurements of the optic disc parameters and RNFL thickness and has been widely used for detection of glaucomatous damage and disease progression. The recent introduction of spectral domain (SD)-OCT technology, also known as Fourier domain (FD)-OCT offers significant advantages over the previous time domain (TD)-OCT, allowing 3D imaging of the retina and optic disc with ultra-high acquisition speed and ultra-high resolution. The higher resolution of (SD)-OCT offers enhanced visualisation and improved segmentation of the retinal layers, providing a higher accuracy in identification of subtle changes of the optic disc and RNFL thinning associated with glaucoma. © Georg Thieme Verlag KG · Stuttgart · New York. Source


Medication safety in hospitals might not be completely guaranteed. However, hospital pharmacists are in charge to increase those safety issues. Therefore it is necessary to carefully analyze the medication process, to identify potential medication errors and to uncover where they appear. Based on such analyses, targeted strategies are needed to reduce medication errors. Risks for the patient safety are often caused at transition sites between different sectors and departments, as well as between different health care professionals. Especially at those sites at higher risk, where several people are involved, a hospital pharmacist should be included as the expert considering medication issues. Frequent causes for medication errors are inadequate knowledge of the patient or the drug, inadequate communication between health care professionals, lack of attention and inadequate awareness of guidelines, ignoring of standard regulations, work overload as well as social issues. All those causes should be reduced together by all health care professionals. Strategies may include the setup of particular guidelines and regulations, trainings conducted by the hospital pharmacist, and an increase of information and adequate communication. One of the most important among such strategies is to increase the awareness and sensitivity for medication errors. Source


Kroller-Schon S.,Universitatsmedizin Mainz
Arteriosclerosis, thrombosis, and vascular biology | Year: 2012

We investigated whether AMP-activated protein kinase (AMPK) may be involved in the signaling processes leading to exercise-mediated vascular protection. The effects of voluntary exercise on AMPK activity, endothelial NO synthase expression and phosphorylation, vascular reactive oxygen species formation, and cell senescence were tested in α1AMPK knockout and corresponding wild-type mice. Exercise significantly improved endothelial function, and increased plasma nitrite production in wild-type mice, associated with an activation of aortic AMPK assessed by its phosphorylation at threonine 172. In addition, regular physical activity resulted in an upregulation of endothelial NO synthase protein, serine 1177 endothelial NO synthase phosphorylation, and an increase of circulating Tie-2(+)Sca-1(+)Flk-1(+) myeloid progenitor cells. All these changes were absent after α1AMPK deletion. In addition, exercise increased the expression of important regulators of the antioxidative defense including heme oxygenase-1 and peroxisome proliferator-activated receptor γ coactivator 1α, decreased aortic reactive oxygen species levels, and prevented endothelial cell senescence in an α1AMPK-dependent manner. Intact α1AMPK signaling is required for the signaling events leading to the manifestation of vascular protective effects during exercise. Pharmacological AMPK activation might be a novel approach in the near future to simulate the beneficial vascular effects of physical activity. Source


The term integrating the healthcare enterprise (IHE) has been known for more than 10 years and provides an innovative approach to ensure interoperability based on a synthesis of different standards for defined scenarios. Acceptance and deployment are, however limited in Germany compared with other countries. In this article the basic principles and the potential of IHE are described. © 2013 Springer-Verlag Berlin Heidelberg. Source

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