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Altona, Germany

Schizoaffective disorders, acute and transient psychoses, and delusional disorders can be located on a continuum from schizophrenia to mood disorders. This theory of a psychotic continuum is supported by research data on genetic, biologic, phenomenological, course related and prognostic characteristics especially of schizoaffective disorders. In contrast, studies on neuropsychological impairments in the psychotic continuum are rare. This limited empirical base will be outlined; two own studies on cognitive performance in bipolar schizoaffective disorders and delusional disorder are presented. Neuropsychological studies extend the theory of a psychotic continuum on gradually increased cognitive impairments between the disorders. Implications for psychiatric diagnostics are discussed.

Fegert J.M.,Universitatsklinikums | Petermann F.,University of Bremen
Kindheit und Entwicklung | Year: 2011

Systematic examinations of whether negative events and experiences during youth and childhood have an effect on a person's life have increased. In 2011 various research, care, and support initiatives concerning children and adolescents traumatized or stressed by sexual abuse, child abuse, and neglect will be launched. In Germany thorough review is necessary. Low-threshold advisory services and forms of evidence-based psychotherapy are recommended. © Hogrefe Verlag, Gottingen 2011.

Hartmann M.,Universitatsklinikums
Tagliche Praxis | Year: 2013

Erysipelas is a severe soft tissue infection usually caused by streptococci. The infection is restricted to the dermis and subcutaneous tissues. Treatment with antibiotics is essential. Clinically is characterized by the rapidly spreading redness and swelling, lymphadenopathy and general symptoms, blistering and superficial haemorrhage are common. The leg is the commonest site, and there is mostly an epithel lesion as a possible portal of entry. The usual treatment is group G penicillin. The median treatment duration is 10 days. Adjuvant measures are anticoagulation, non-steroidal anti-inflammatory agents, dressings, immobilization and treatment of local predisposing factors such as inter- digital tinea.

A case of a chronic lymphatic leukemia (CLL) of a chemicals worker, who was exposed to ethylene oxide (EO) at the workplace for several years, is presented. From the occupational health point of view, it must be assessed whether CLL, according to the new classification of Non-Hodgin lymphoma, fulfils the preconditions of an occupational disease. The decisive factors for the causality assessment are the current findings on the human carcinogenicity of ethylene oxide, the estimation of the quantitative risk after occupational exposure to EO and the assessment of temporal processes between exposure and disease.

Diseases previously known as »chronic myeloproliferative diseases« are grouped as »myeloproliferative neoplasms« since the update of the WHO classification in 2008. All members of this group are neoplastic diseases of hematopoetic cells that are only slowly progressive and lead to massive proliferation of one or several cell lineages in the bone marrow, mostly accompanied by an increase of leukocytes, thrombocytes and/or erythrocytes circulating in the peripheral blood. Prominent members within this division of neoplasms are chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) besides other, rare diseases. The Philadelphia-chromosome was described in patients with CML in 1960 and is a long-standing part of the diagnostic criteria for this disease. In 2005 the JAK2 mutation V617F was described in different frequency in all Philadelphia-negative MPN and was thus introduced into the WHO criteria for MPN in 2008. For a diagnosis of a specific MPN, clinical, pathological and molecular criteria thus have to be regarded together and are described.

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