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Bad Münster am Stein-Ebernburg, Germany

Livedo vasculopathy is a chronic recurrent disease of the cutaneous circulation and is characterized by episodic occurrence of painful ulcerations of the lower leg. These heal slowly leaving small porcelain-white scars called atrophie blanche. Recent research has shown that livedoid vasculopathy is a coagulation disorder classified as a vasculopathy different from inflammatory vasculitis. Distinguishing between the disorders enhances the pathophysiologic understanding and supports the therapeutic rationale. The prevention of irreversible residual scarring is the main goal in treating cutaneous infarction; prompt treatment is required. © 2011 Springer-Verlag. Source

Groll A.H.,Universitatsklinikum Munster | Lumb J.,Medical Writer
Future Microbiology | Year: 2012

Invasive fungal infections continue to be a major cause of morbidity and mortality in immunocompromised or severely ill patients. This report highlights new research data presented at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy on invasive fungal disease and its treatment. A number of important clinical trials were reported, and there were also interesting presentations on the use of new diagnostic tools, further studies on therapeutic drug monitoring for azoles and updates on several of the emerging fungal pathogens. © 2012 Future Medicine Ltd. Source

Research biomaterial banks (biobanks) are institutions which collect and prepare samples of human bodily substances (e.g. cells, tissues, body fluids and isolates from them), store personal, health and problem-related data of donors, collate samples and data and make them available in a suitable form for research purposes. The valid legal norms for the utilization and running of biobanks are complex and sometimes necessitate an assessment by the legal guardian. © 2013 Springer-Verlag Berlin Heidelberg. Source

In recent years forensic age diagnostics in living adolescents and young adults has become more and more important. In Germany the legally relevant age limits are 14, 16, 18, and 21 years of age. In accordance with the recommendations of the Study Group on Forensic Age Diagnostics (Arbeitsgemeinschaft für Forensische Altersdiagnostik, AGFAD), the following tests should be performed in combination for age estimation: a physical examination, an X-ray examination of the hand, a dental examination including an orthopantomogram as well as an additional X-ray examination of the clavicles with completed development of the hand skeleton. Without an authorization for an X-ray examination the spectrum of methods is limited to a physical examination and determination of the dental status. Based on the use of radiation-free imaging procedures a clear improvement in the reliability of these age estimates is expected. The influence of ethnicity and socioeconomic status on the examined age characteristics must be considered in the assessment. © 2011 Springer-Verlag. Source

Stolting M.,Universitatsklinikum Munster
PloS one | Year: 2012

Eukaryotic cells form a variety of adhesive structures to connect with their environment and to regulate cell motility. In contrast to classical focal adhesions, podosomes, highly dynamic structures of different cell types, are actively engaged in matrix remodelling and degradation. Podosomes are composed of an actin-rich core region surrounded by a ring-like structure containing signalling molecules, motor proteins as well as cytoskeleton-associated proteins. Lasp-1 is a ubiquitously expressed, actin-binding protein that is known to regulate cytoskeleton architecture and cell migration. This multidomain protein is predominantely present at focal adhesions, however, a second pool of Lasp-1 molecules is also found at lamellipodia and vesicle-like microdomains in the cytosol.In this report, we show that Lasp-1 is a novel component and regulator of podosomes. Immunofluorescence studies reveal a localization of Lasp-1 in the podosome ring structure, where it colocalizes with zyxin and vinculin. Life cell imaging experiments demonstrate that Lasp-1 is recruited in early steps of podosome assembly. A siRNA-mediated Lasp-1 knockdown in human macrophages affects podosome dynamics as well as their matrix degradation capacity. In summary, our data indicate that Lasp-1 is a novel component of podosomes and is involved in the regulation of podosomal function. Source

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