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Heidelberg, Germany

Eating disorders are serious illnesses predominantly affecting adolescents and young adults. Effective prevention is strongly desired. Estimates of the individual risk are often vague. Therefore, stepwise strategies, such as the German Internet-delivered program YoungEs[s]prit, are appealing. The prospective, randomized controlled intervention study presented here investigated the efficacy of YoungEs[s]prit. The study was conducted in two waves applying an adaptive design. The main outcome was the cumulative incidence rate (according to DSM-IV criteria) over 12 months. Efficacy was statistically tested through survival-analytic methods. Results from the first wave (n = 896) proved the preventive efficacy of YoungEs[s]prit (log rank x2 = 4.29, df = 1, p =. 038,2-sided) with a hazard ratio of 1.67. The cumulative incidence rate of 9.6 % in the control condition was reduced to 5.9 % in the YoungEs[s]prit condition. Results from the second wave (n = 771) could not show any significant differences between the groups (4.8 % vs. 5.6 %, log rank c2 = 0.27, df = 1, p =. 600,2-sided). Taking the results of the two waves together, as required by the adaptive design, the study did not prove efficacy. While the rate of 9.6 % in the first wave corresponds to the estimate of about 10 % reported in the literature, the rate of 4.8 % appears unusually small. Therefore, it was explored whether (1) differences between the samples, e. g., the greater proportion of girls in the second wave, (2) a shorter distance to health services in the second wave, or (3) the possibly increased awareness of eating disorders through the activities in the first wave may have contributed to the differences between the estimates for the two waves. © Hogrefe Verlag, Göttingen 2015. Source

Strowitzki T.,Universitatsklinikum Heidelberg
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Year: 2013

Background: The incidence of female infertility has not changed since the early 1990s. Based on new data from basic research on infertility, novel options in the diagnostics and treatment of infertility have emerged, besides in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Aim: This review summarizes the current knowledge on female infertility and on modern concepts in diagnostics and treatment. Methods: A literature research on the causes of infertility and on treatment options was performed, including demographic factors, infectiology, anatomy, endocrinology and metabolism, endometriosis, lifestyle and environmental factors, and psychological factors. Results: Chlamydial infection is still the major cause of tubal infertility. Improvement of the patient's fertility by correction of endocrine and metabolic disorders, in particular thyroid dysfunction and glucose metabolism, as well as fertility surgery are of main interest. Conclusions: Besides assisted reproductive techniques, concepts to optimize individual fertility have gained increasing importance. © 2013 Springer-Verlag Berlin Heidelberg. Source

Affect dysregulation and impulsivity are the main topics of neurobiological research in borderline personality disorder. Affect dysregulation subsumes enhanced resting arousal, increased emotional responsiveness as well as deficient emotional regulation and is associated with structural and functional abnormalities in a prefrontal-limbic network, above all orbitofrontal hypoactivity and amygdalar as well as insular hyperactivity. Impulsivity describes a lack of future-oriented problem solving style as well as a decreased threshold for motoric responses and is associated with decreased serotonergic activity in the ventral prefrontal cortex. Future research has to clarify how specific the findings of borderline personality disorder are and how far temperament dimensions, such as neuroticism can explain the neurobiological deviations from the norm. © 2011 Springer-Verlag. Source

The working group on pulmonary pathology of the German Society of Pathology (Deutsche Gesellschaft für Pathologie, DGP) developed very actively in the last year. Apart from the autumn meeting in Heidelberg in 2011 and the sessions at the annual DGP meeting in Berlin it was possible to realize a first publication with support and coauthorship of several members of the working group dealing with the classification of lung adenocarcinoma. In this report the key aspects of the activity related to the following issues are summarized including non-small cell lung carcinoma, neuroendocrine tumors of the lungs, interstitial pulmonary diseases, cell blocks in cytology and banking in thoracic pathology. Source

Brandt F.,Max Planck Institute of Biochemistry | Carlson L.-A.,Max Planck Institute of Biochemistry | Carlson L.-A.,Universitatsklinikum Heidelberg | Hartl F.U.,Max Planck Institute of Biochemistry | And 2 more authors.
Molecular Cell | Year: 2010

Structural studies have provided detailed insights into different functional states of the ribosome and its interaction with factors involved in nascent peptide folding, processing, and targeting. However, how the translational machinery is organized spatially in native cellular environments is not yet well understood. Here we have mapped individual ribosomes in electron tomograms of intact human cells by template matching and determined the average structure of the ribosome in situ. Characteristic features of active ribosomes in the cellular environment were assigned to the tRNA channel, elongation factors, and additional densities near the peptide tunnel. Importantly, the relative spatial configuration of neighboring ribosomes in the cell is clearly nonrandom. The preferred configurations are specific for active polysomes and were largely abrogated in puromycin-treated control cells. The distinct neighbor orientations found in situ resemble configurations of bacterial polysomes in vitro, indicating a conserved supramolecular organization with implications for nascent polypeptide folding. © 2010 Elsevier Inc. Source

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