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Heidelberg, Germany

Strowitzki T.,Universitatsklinikum Heidelberg
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Year: 2013

Background: The incidence of female infertility has not changed since the early 1990s. Based on new data from basic research on infertility, novel options in the diagnostics and treatment of infertility have emerged, besides in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Aim: This review summarizes the current knowledge on female infertility and on modern concepts in diagnostics and treatment. Methods: A literature research on the causes of infertility and on treatment options was performed, including demographic factors, infectiology, anatomy, endocrinology and metabolism, endometriosis, lifestyle and environmental factors, and psychological factors. Results: Chlamydial infection is still the major cause of tubal infertility. Improvement of the patient's fertility by correction of endocrine and metabolic disorders, in particular thyroid dysfunction and glucose metabolism, as well as fertility surgery are of main interest. Conclusions: Besides assisted reproductive techniques, concepts to optimize individual fertility have gained increasing importance. © 2013 Springer-Verlag Berlin Heidelberg. Source


Affect dysregulation and impulsivity are the main topics of neurobiological research in borderline personality disorder. Affect dysregulation subsumes enhanced resting arousal, increased emotional responsiveness as well as deficient emotional regulation and is associated with structural and functional abnormalities in a prefrontal-limbic network, above all orbitofrontal hypoactivity and amygdalar as well as insular hyperactivity. Impulsivity describes a lack of future-oriented problem solving style as well as a decreased threshold for motoric responses and is associated with decreased serotonergic activity in the ventral prefrontal cortex. Future research has to clarify how specific the findings of borderline personality disorder are and how far temperament dimensions, such as neuroticism can explain the neurobiological deviations from the norm. © 2011 Springer-Verlag. Source


The working group on pulmonary pathology of the German Society of Pathology (Deutsche Gesellschaft für Pathologie, DGP) developed very actively in the last year. Apart from the autumn meeting in Heidelberg in 2011 and the sessions at the annual DGP meeting in Berlin it was possible to realize a first publication with support and coauthorship of several members of the working group dealing with the classification of lung adenocarcinoma. In this report the key aspects of the activity related to the following issues are summarized including non-small cell lung carcinoma, neuroendocrine tumors of the lungs, interstitial pulmonary diseases, cell blocks in cytology and banking in thoracic pathology. Source


Brandt F.,Max Planck Institute of Biochemistry | Carlson L.-A.,Max Planck Institute of Biochemistry | Carlson L.-A.,Universitatsklinikum Heidelberg | Hartl F.U.,Max Planck Institute of Biochemistry | And 2 more authors.
Molecular Cell | Year: 2010

Structural studies have provided detailed insights into different functional states of the ribosome and its interaction with factors involved in nascent peptide folding, processing, and targeting. However, how the translational machinery is organized spatially in native cellular environments is not yet well understood. Here we have mapped individual ribosomes in electron tomograms of intact human cells by template matching and determined the average structure of the ribosome in situ. Characteristic features of active ribosomes in the cellular environment were assigned to the tRNA channel, elongation factors, and additional densities near the peptide tunnel. Importantly, the relative spatial configuration of neighboring ribosomes in the cell is clearly nonrandom. The preferred configurations are specific for active polysomes and were largely abrogated in puromycin-treated control cells. The distinct neighbor orientations found in situ resemble configurations of bacterial polysomes in vitro, indicating a conserved supramolecular organization with implications for nascent polypeptide folding. © 2010 Elsevier Inc. Source


Patent
Universitatsklinikum Heidelberg | Date: 2010-04-16

The present invention relates to a peptide comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptide for medical use, in particular, for treating or preventing disorders associated with muscular malfunction, such as skeletal muscle or cardiac muscle disorders. The present invention also provides a pharmaceutical composition comprising said peptide and a method for treating or preventing disorders associated with muscular malfunction using said peptide or said pharmaceutical composition.

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