Universitatsklinik Ulm

Neu-Ulm, Germany

Universitatsklinik Ulm

Neu-Ulm, Germany
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Facilitating participation of children with disabilities is one of the central aims both of the UN conventions of the rights of persons with disabilities as well as of the rights of the child. Core domains for the inclusion of children are school, peer-relations and family life. Actually, actions for handicapped children are defined in several Social Codes in Germany, depending whether a child has a psychiatric disorder or is intellectual or physically disabled. The different social codes lead to problems for the families and is not realistic, as children often suffer on multiple disabilities. Initiatives for the implementation of one Social Code for all children with all forms of disability is ongoing. A structured and scientific evaluated assessment of the individual barriers for participation, also in academic performance are needed. Some of already developed assessments are presented. © Schattauer 2017.

Trainotti S.,Universitatsklinik Ulm | Scheithauer M.,Universitatsklinik Ulm
HNO | Year: 2017

Skin damage induces the wound healing process which leads to primary or secondary healing in three sequential, partially overlapping phases, due to interaction among different cells and secretion of pro- and anti-inflammatory mediators. The subtle equilibrium among repair and breakdown can be disturbed by different local and systemic factors causing impairment or even stagnancy of a phase with the effect of chronic wounds or deficient healing. Various surgical and nonsurgical instruments can be used to promote disturbed towards physiologic healing and restore the integrity of the organism’s protective layer. © 2017 Springer Medizin Verlag GmbH

Ferreira J.J.,University of Lisbon | Rosser A.,University of Cardiff | Craufurd D.,University of Manchester | Squitieri F.,IRCSS Neuromed | And 2 more authors.
Movement Disorders | Year: 2015

Background: It has been suggested that treatment with ethyl-eicosapentaenoic acid (EPA) may improve motor function in patients with Huntington's disease (HD) with cytosine-adenine-guanine repeat numbers of <45. Methods: This multicenter, randomized, double-blind, placebo-controlled 6-month trial compared the effects of ethyl-EPA versus placebo on 290 subjects with mild-to-moderate HD. The primary endpoint was the change from baseline to 6 months in the Total Motor Score 4 (TMS-4) component of the Unified Huntington's Disease Rating Scale (UHDRS). Secondary endpoints included change from baseline in UHDRS subscores and Clinical Global Impression (CGI). Results: No significant differences in TMS-4 scores were noted between treatment groups. Similarly, there were no significant differences between groups on any of the UHDRS subscores or CGI scores. Conclusion: Ethyl-EPA was not beneficial in patients with HD during 6 months of placebo-controlled evaluation. © 2015 International Parkinson and Movement Disorder Society.

Rohde G.,Ruhr University Bochum | Straube E.,Friedrich - Schiller University of Jena | Essig A.,Universitatsklinik Ulm | Reinhold P.,Institute For Molekulare Pathogenese | Sachse K.,Institute For Molekulare Pathogenese
Deutsches Arzteblatt | Year: 2010

Background: Zoonoses were already a subject of intense interest even before the SARS and avian influenza epidemics arose. For many years, chlamydiae have been hypothesized to be important zoonotic pathogens, because of their wide distribution and their infectious cycle. This article provides an overview of the current state of knowledge on this subject. Methods: The authors present a selective review of the literature as well as their own findings. Results: The scientific knowledge of the distribution and infectious cycle of chlamydiae is still inadequate. The laboratory diagnosis of chlamydial zoonoses remains unsatisfactory in both human and vet erinary medicine, as there are no commercially available sensitive and species-specific tests. Acute chlamydial infections are usually treated with macrolides, tetracyclines, or quinolones. Persistent varieties are not covered by standard therapy. Conclusions: There is a considerable need for research on chlamydial infections, especially with regard to the diagnosis and treatment of persistent varieties.

Plener P.L.,Universitatsklinik Ulm | Fegert J.M.,Universitatsklinik Ulm | Kolch M.G.,Universitatsklinik Ulm | Kolch M.G.,Vivantes Netzwerk fur Gesundheit GmbH
Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie | Year: 2012

Depending on symptom severity, psychopharmacological treatment can be a valuable option in the treatment of depressive disorders in childhood and adolescence. This review provides recommendations for clinical treatment, focusing on suicidality and treatment-resistant patients. The quality of studies regarding the psychopharmacological therapy of depressive disorders in childhood and adolescence has improved since the «black box» warning of the FDA concerning the occurrence of suicidality under treatment with selective serotonin reuptake inhibitors (SSRIs). In Germany, there is proof for a trend toward a more evidence-based psychopharmacological treatment approach within recent years. © 2012 Verlag Hans Huber, Hogrefe AG.

Thermann P.,Klinik fur Innere Medizin IV | Dollinger M.M.,Universitatsklinik Ulm
Zeitschrift fur Gastroenterologie | Year: 2016

Sarcoidosis is a rare systemic disease characterized by noncaseating granulomas in affected organs. With > 90 % of all cases lung involvement is the most frequent site of manifestation of sarcoidosis, nevertheless multiple other organs can be affected. Extrapulmonary manifestations are lymph nodes, skin, nervous system, heart, eyes, bone marrow, spleen or gastrointestinal tract including liver and pancreas. Involvement of the gastrointestinal tract is rare, it can affect the whole intestine and is most frequently found in the stomach. Despite its infrequent manifestation, gastrointestinal sarcoidosis can have a significant clinical impact depending on the organ involved, so that early diagnosis is warranted. Medical treatment mainly consists of immunosuppressive therapy, most frequently with corticosteroids being the first treatment of choice. Dosage and duration of therapy is not well established yet. In the literature very limited data are available on this topic with randomized trials missing completely. The aim of this paper is to give a summary of the available data to this date. © Georg Thieme Verlag KG.

Plener P.L.,Universitatsklinik Ulm | Straub J.,Universitatsklinik Ulm | Fegert J.M.,Universitatsklinik Ulm | Keller F.,Universitatsklinik Ulm
Nervenheilkunde | Year: 2015

Recent data from the nationwide German KiGGS survey show a stable level of psychiatric and behavioural symptoms in a community sample. Nevertheless, rates of psychopharmacological treatment in childhood and adolescence are increasing. This study analyses the prevalence of ICD-10 chapter F diagnoses, from German hospitals in children up to the age of 15 in the years 2003 to 2012. There was a significant increase in most diagnostic groups with the exception of organic (F0), schizophrenic (F2), personality and behavioral disorders (F6) and mental retardation (F7), showing stable or even decreasing rates of hospital treatments in a 10 year time frame. © Schattauer 2015

Laszlo R.,Universitatsklinik Ulm | Steinacker J.M.,Universitatsklinik Ulm
Herz | Year: 2016

A training-induced increase in vagal tone, left atrial enlargement and high atrial volume load due to exercise can theoretically favor induction and continuation of atrial fibrillation (AF) in (endurance) athletes. However, there is currently no evidence for a higher occurrence of AF in young endurance athletes in comparison to an age-matched normal population. The correlate of long-term endurance training results in proarrhythmogenic atrial remodeling in a rat model. The results of some studies also suggest that there may be atrial remodeling in humans, which might be an explanation for the comparatively higher incidence of AF in veteran athletes, whereby the relative risk might have been overestimated due to methodological problems, e.g. due to insufficient consideration of “new” AF risk factors. To date, there are no indications for an increased risk of AF due to normal physical activity: on the contrary, moderate physical activity seems to decrease the risk for AF. For an individual evaluation of sports participation of patients with AF, the overall cardiac situation, atrioventricular conduction during exercise, a possible oral anticoagulation as well as the sport and training intensity practiced are important. Well-adapted training for patients with AF has to be considered as safe and effective in terms of the overall positive effects of physical activity in patients with cardiovascular problems, for example due to a positive influence on cardiovascular risk factors. © 2015, Urban & Vogel.

Barrech A.,Universitatsklinik Ulm
Public Health Forum | Year: 2014

The structural changes and economic crises of the past decades have led to an increase in job insecurity among employees worldwide (OECD, 1997; Eurofound, 2012). Current research suggests that job insecurity is a work-related stressor which can have detrimental effects on psychological, as well as somatic health (Greenhalgh and Rosenblatt, 2010). To date, there is a lack of studies on preventive approaches, especially in work-settings. With regards to the individual and societal implications of job insecurity, the validation of appropriate interventions is called for.

Up to one-third of all schizophrenic patients suffer from auditory verbal hallucinations (AVH) that are resistant to antipsychotics. The use of repetitive transcranial magnetic stimulation (rTMS) is a therapeutic option that may disrupt or attenuate treatment resistant (TR) AVHs. This article reviews the available literature on the use of rTMS to treat AVHs, particularly focusing on randomised controlled trials, which have introduced new definitions (refractory AVHs), and techniques (active comparator strategies and imaging-guided rTMS). A number of meta-analyses are considered, which support a range of positive effect sizes for AVH attenuation in response to rTMS. Larger maintenance and follow-up studies with clearer clinical definitions of TR AVH are required. The underlying mechanism of action of rTMS on language networks needs further clarification and future trials should focus on methods for assessing AVH changes, time courses of response, and the development of response markers. © Georg Thieme Verlag KG Stuttgart · New York.

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