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Gutwald R.,University Hospital Freiburg | Gutwald R.,Universitatsklinik For Zahn Mund Und Kieferheilkunde | Schon R.,University Hospital Freiburg | Metzger M.,University Hospital Freiburg | And 4 more authors.
International Journal of Oral and Maxillofacial Surgery

The aim of this study was to compare a combination of a locking system with self-tapping (ST-L) or self-drilling-tapping (SDT-L) screws with a combination of conventional miniplates with self-tapping (ST) and self-forming (SF) screws. A standardized osteotomy and osteosynthesis with one of the above mentioned systems was performed in 24 sheep. Callus formation was measured with the help of CT scans assisted by a navigation system. Specimens of each osteotomy gap were taken and examined histologically. The best results were observed when self-tapping screws and the Mini-Locking-System (ST-L) were applied. The slowest healing was seen in animals treated with miniplates and SF screws. After 8 weeks an increase in bone formation could be observed in the ST, SF, SDT-L systems. The results after 8 weeks were comparable with those achieved by the ST-L system after 4 weeks. The improved stability of the osteosynthesis with the ST-L system resulted in early ossification of the osteotomy gap and the smallest amount of callus formation. © 2010 International Association of Oral and Maxillofacial Surgeons. Source

Sauerbier S.,Universitatsklinik For Zahn Mund Und Kieferheilkunde | Stricker A.,Universitatsklinik For Zahn Mund Und Kieferheilkunde | Kuschnierz J.,Universitatsklinik For Zahn Mund Und Kieferheilkunde | Buhler F.,Universitatsklinik For Zahn Mund Und Kieferheilkunde | And 5 more authors.
Tissue Engineering - Part C: Methods

Objective: To compare new bone formation in maxillary sinus augmentation procedures using biomaterial associated with mesenchymal stem cells (MSCs) separated by two different isolation methods. Background: In regenerative medicine open cell concentration systems are only allowed for clinical application under good manufacturing practice conditions. Methods: Mononuclear cells, including MSCs, were concentrated with either the synthetic poylsaccharid (FICOLL) method (classic open system-control group, n=6 sinus) or the bone marrow aspirate concentrate (BMAC) method (closed system-test group, n=12 sinus) and transplanted in combination with biomaterial. A sample of the cells was characterized by their ability to differentiate. After 4.1 months (SD±1.0) bone biopsies were obtained and analyzed. Results: The new bone formation in the BMAC group was 19.9% (90% confidence interval [CI], 10.9-29), and in the FICOLL group was 15.5% (90% CI, 8.6-22.4). The 4.4% difference was not significant (90% CI,-4.6-13.5; p=0.39). MSCs could be differentiated into osteogenic, chondrogenic, and adipogenic lineages. Conclusion: MSCs harvested from bone marrow aspirate in combination with bovine bone matrix particles can form lamellar bone and provide a reliable base for dental implants. The closed BMAC system is suited to substitute the open FICOLL system in bone regeneration procedures. © 2010, Mary Ann Liebert, Inc. Source

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