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Mueck A.O.,Universitats Frauenklinik Tubingen und | Buhling K.,Universitatsklinikum Hamburg Eppendorf
Gynakologische Endokrinologie | Year: 2013

Cardiovascular diseases are the most common cause of mortality in the late postmenopause. The importance of estrogen deficiency is easy to recognize by the fact that the mortality increases exponentially after the menopause and particularly with rapid decreases in estrogen production, for example by bilateral oophorectomy. Besides age related alteration, the negative alterations in lipid and glucose metabolism, increase in hypertension, visceral fat, diabetes and metabolic syndrome are in correlation with the time span to the menopause and with this also to the estrogen deficiency. In contrast, estrogen treatment in the menopause has a positive effect on all these risk factors. More than 1,000 investigations indicate the cardiovascular preventive mechanisms of estrogen. However, in clinical studies a cardiovascular protection is only achieved if hormone substitution is initiated within 10 years after the menopause at the latest whereby the total mortality can be significantly reduced, in contrast to statins. Estrogen deficiency is therefore without a doubt the major cause of cardiovascular mortality in women in the late postmenopause. © 2013 Springer-Verlag Berlin Heidelberg. Source

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