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Granada, Spain

Cutando A.,University of Granada | Aneiros-Fernandez J.,Universitario Of Granada | Lopez-Valverde A.,University of Salamanca | Arias-Santiago S.,Universitario Of Granada | And 2 more authors.
Archives of Oral Biology

Background: Melatonin is involved in many physiological processes in mammals, amongst others; it is implicated in sleep-wake regulation. It has antioxidant and anti-inflammatory properties. It also acts as an immunomodulator, stimulates bone metabolism and inhibits various tumours. Additionally an abnormal melatonin rhythm may contribute to depression and insomnia. The mechanisms of action of melatonin include the involvement of membrane receptors (MT1, MT2), cytosolic binding sites (MT3 and calmodulin), and nuclear receptors of the RZR/ROR family. Melatonin also has receptor-independent activity and can directly scavenge free radicals. The current review addresses the functions of melatonin in the oral cavity in relation to its receptors. Methods: An extensive search was conducted on the following scientific databases Pub Med, Science Direct, ISI Web of Knowledge and Cochrane database in order to review all pertinent literature. Results: Melatonin from the blood into the saliva may play an important role in suppressing oral diseases. It may have beneficial effects in periodontal disease, herpes and oral cancer, amongst others. Conclusions: Melatonin contributes to protecting of oral cavity from tissue damage due to its action of different receptors. From the reviewed literature it is concluded that experimental evidence suggests that melatonin can be useful in treating several common diseases of the oral cavity. Specific studies are necessary to extend the therapeutic possibilities of melatonin to other oral diseases. © 2011 Elsevier Ltd. Source

Lopez Espada C.,Universitario Of Granada | Lozano Alonso S.,Universitario Of Granada | Bravo Molina A.,Universitario Of Granada

Men have a higher prevalence in most vascular diseases and women are under-represented in the mayority of the trials. Therefore, a vast mayority of clinical decisions based on these, might not be suitable for women. A review of current recommendations and the literature is presented to help to identify gender differences for patients with abdominal aortic aneurysms, carotid artery disease, and peripheral arterial disease. Most of them emphasize that women are older than men and cardiovascular risk factors are under-treated in comparison to men. The evidence suggests that women are at higher risk of aneurysm rupture when compared with men and that, when rupture occurs, it does so at smaller diameters with higher morbidity and mortality, whether by open or endovascular repair. For carotid disease, it has been suggested that carotid plaques in women tend to be more stable, which may result in surgery not being as effective as in males, and should be more restrictive when operating asymptomatic or symptomatic women with moderate stenosis (50-69%). Finally, regarding lower limb revascularization procedures, there is not enough evidence to show differences between sexes in patency, limb salvage rate, perioperative mortality, or long-term survival. © 2015 SEACV. Source

Perez-Ramirez C.,Universitario Of Granada | Perez-Ramirez C.,University of Granada | Canadas-Garre M.,Universitario Of Granada | Jimenez-Varo E.,Universitario Of Granada | And 4 more authors.

Non-small-cell lung cancer (NSCLC) leads cancer-related deaths worldwide. Mutations in the kinase domain of the EGFR gene provide sensitivity to tyrosine kinase inhibitors (TKI) drugs. TKI show initial response rates over 75% in mutant EGFR-NSCLC patients, although most of these patients acquire resistance to EGFR inhibitors after therapy. EGFR-TKI resistance mechanisms include amplification in MET and its ligand, and also MET mutations. MET signaling dysregulation has been involved in tumor cell growth, survival, migration and invasion, angiogenesis and activation of several pathways, therefore representing an attractive target for anticancer drug development. In this review, we will discuss MET-related mechanisms of EGFR-TKI resistance in NSCLC, as well as the main drugs targeted to inhibit MET pathway. © 2015 Future Medicine Ltd. Source

Perez-Parra S.,Universitario Of Granada | Pena A.,Universitario Of Granada | Blanca E.,Universitario Of Granada | Garcia F.,Universitario Of Granada
Revista Chilena de Infectologia

We present a case report of a infective endocarditis by Corynebacterium pseudodiphtheriticum in a young patient eight years old with bicuspid aortic valve that led to a severe neurological embolism and death. Corynebacterium pseudodiphtheriticum is part of the nasopharyngeal and skin flora. However, there are cases reported of endocarditis usually associated with immunocompromised patients that mostly presented a poor clinical outcome. © 2016, Sociedad Chilena de Infectologia. All rights reserved. Source

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