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Biasiolo L.,University of Udine | Trinchillo M.,Universitafederico Ii Of Naples | Belanzoni P.,University of Perugia | Belpassi L.,CNR Institute of Molecular Science and Technologies | And 6 more authors.
Chemistry - A European Journal | Year: 2014

The intermolecular alkoxylation of alkynes is the oldest application of cationic gold(I) catalysts; however, no systematic experimental data about the role of the anion are available. In this contribution, the role of the anion in this catalytic reaction as promoted by a N-heterocyclic carbene-based gold catalyst, [(NHC)AuX] (X = BARF- BF4 - , OTf- ,OTs-, TFA- , or OAc- ) is analyzed, through a combined experimental (NMR spectroscopy) and theoretical (DFT calculation) approach. The most important factor seems to be the ability to abstract the proton from the methanol during the nucleophilic attack, and such ability is related to the anion basicity. On the other hand, too high coordination power or basicity of the anion worsens the catalytic performance by preventing alkyne coordination or by forming too much free methoxide in solution, which poisons the catalyst. The intermediate coordinating power and basicity of the OTs- anion provides the best compromise to achieve efficient catalysis. ©2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Prisciandaro M.,University of L'Aquila | Capocelli M.,The Second University of Naples | Lancia A.,Universitafederico Ii Of Naples | Musmarra D.,University of L'Aquila | And 3 more authors.
Chemical Engineering Transactions | Year: 2014

The recent regulation policies and an increasing public concern are focusing on the presence of priority and emerging pollutant in water. In order to obtain high efficiencies on their abatement in the prevention and remediation of water sources, the Advanced Oxidation Processes (AOP) are among the most interesting and reliable opportunities. Although they have shown a great potential, their employment in waste water treatment plants is still unsatisfactory mainly because of the elevated treatment cost. A great opportunity is given by hybrid cavitation techniques offering low energy consumption. When applied individually hydrodynamic cavitation (HC), often gives insufficient removal percentage degradation, but its efficacy can be significantly enhanced by combining it with other advanced oxidation processes such as Fenton-like treatments. The research study presents the preliminary results of an experimental campaign with the aim of optimizing the process of hybrid HC oxidation and individuating its feasibility in removing emerging pollutants. This paper focuses on the parallel and combined treatment of HC/Fenton and HC/Activated Persulfate, by evaluating the synergistic index and the energy consumption in the p-nitrophenol (pNP) degradation. Copyright © 2014, AIDIC Servizi S.r.l.


PubMed | CNR Institute of Molecular Genetics, University of Genoa, Universitafederico Ii Of Naples, University of Siena and CNR Institute of Clinical Physiology
Type: | Journal: European journal of medicinal chemistry | Year: 2017

In the last few years, several pyrrolo-pyrimidine derivatives have been either approved by the US FDA and in other countries for the treatment of different diseases or are currently in phase I/II clinical trials. Herein we present the synthesis and the characterization of a novel series of pyrrolo[2,3-d]pyrimidines, compounds 8a-j, and their activity against Glioblastoma multiforme (GBM). Docking studies and MM-GBSA analysis revealed the ability of such compounds to efficiently interact with the ATP binding site of Src. Enzymatic assays against a mini-panel of kinases (Src, Fyn, EGFR, Kit, Flt3, Abl, AblT315I) have been performed, showing an unexpected selectivity of our pyrrolo[2,3-d]pyrimidines for Src. Finally, the derivatives were tested for their antiproliferative potency on U87 GBM cell line. Compound 8h showed a considerable cytotoxicity effect against U87cell line with an IC


Negri S.,University of Salento | Margiotta S.,University of Salento | Maria Quarta T.A.,University of Salento | Castiello G.,Universitafederico Ii Of Naples | And 2 more authors.
Journal of Cave and Karst Studies | Year: 2015

In Cutrofiano, in the southern part of the Salento Peninsula, Apulia, Italy, a Pleistocene calcarenitic sequence was quarried by digging extensive networks of galleries along the geological succession most suitable for the quarrying activity. These caves represent a potential hazard for the built-up environment due to the occurrence of underground instability that may propagate upward and eventually reach the surface, causing sinkholes. In this work we propose integrated interdisciplinary methods for cavities detection. The methodology was applied at a test area located along a major road near Cutrofiano using geological and electrical-resistivity tomography and microgravity geophysical methods. © 2015 National Speleological Society Inc. All Rights Reserved.

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