Cortesi A.,University of Nottingham |
Cortesi A.,European Southern Observatory |
Merrifield M.R.,University of Nottingham |
Arnaboldi M.,European Southern Observatory |
And 12 more authors.
Monthly Notices of the Royal Astronomical Society | Year: 2011
To investigate the origins of S0 galaxies, we present a new method of analysing their stellar kinematics from discrete tracers such as planetary nebulae. This method involves binning the data in the radial direction so as to extract the most general possible non-parametric kinematic profiles, and using a maximum-likelihood fit within each bin in order to make full use of the information in the discrete kinematic tracers. Both disc and spheroid kinematic components are fitted, with a two-dimensional decomposition of imaging data used to attribute to each tracer a probability of membership in the separate components. Likelihood clipping also allows us to identify objects whose properties are not consistent with the adopted model, rendering the technique robust against contaminants and able to identify additional kinematic features. The method is first tested on an N-body simulated galaxy to assess possible sources of systematic error associated with the structural and kinematic decomposition, which are found to be small. It is then applied to the S0 system NGC 1023, for which a planetary nebula catalogue has already been released and analysed by Noordermer et al. The correct inclusion of the spheroidal component allows us to show that, contrary to previous claims, the stellar kinematics of this galaxy are indistinguishable from those of a normal spiral galaxy, indicating that it may have evolved directly from such a system via gas stripping or secular evolution. The method also successfully identifies a population of outliers whose kinematics are different from those of the main galaxy; these objects can be identified with a stellar stream associated with the companion galaxy NGC 1023A. © 2011 The Authors Monthly Notices of the Royal Astronomical Society © 2011 RAS.
Verloes A.,University Paris Diderot |
Verloes A.,French Institute of Health and Medical Research |
Di Donato N.,Carl Gustav Carus Institute |
Masliah-Planchon J.,University Paris Diderot |
And 47 more authors.
European Journal of Human Genetics | Year: 2015
Baraitser-Winter, Fryns-Aftimos and cerebrofrontofacial syndrome types 1 and 3 have recently been associated with heterozygous gain-of-function mutations in one of the two ubiquitous cytoplasmic actin-encoding genes ACTB and ACTG1 that encode β- and γ-actins. We present detailed phenotypic descriptions and neuroimaging on 36 patients analyzed by our group and six cases from the literature with a molecularly proven actinopathy (9 ACTG1 and 33 ACTB). The major clinical anomalies are striking dysmorphic facial features with hypertelorism, broad nose with large tip and prominent root, congenital non-myopathic ptosis, ridged metopic suture and arched eyebrows. Iris or retinal coloboma is present in many cases, as is sensorineural deafness. Cleft lip and palate, hallux duplex, congenital heart defects and renal tract anomalies are seen in some cases. Microcephaly may develop with time. Nearly all patients with ACTG1 mutations, and around 60% of those with ACTB mutations have some degree of pachygyria with anteroposterior severity gradient, rarely lissencephaly or neuronal heterotopia. Reduction of shoulder girdle muscle bulk and progressive joint stiffness is common. Early muscular involvement, occasionally with congenital arthrogryposis, may be present. Progressive, severe dystonia was seen in one family. Intellectual disability and epilepsy are variable in severity and largely correlate with CNS anomalies. One patient developed acute lymphocytic leukemia, and another a cutaneous lymphoma, indicating that actinopathies may be cancer-predisposing disorders. Considering the multifaceted role of actins in cell physiology, we hypothesize that some clinical manifestations may be partially mutation specific. Baraitser-Winter cerebrofrontofacial syndrome is our suggested designation for this clinical entity. © 2015 Macmillan Publishers Limited All rights reserved.
Messina G.,University of Rome La Sapienza |
Damia E.,University of Rome La Sapienza |
Fanti L.,University of Rome La Sapienza |
Atterrato M.T.,University of Rome La Sapienza |
And 13 more authors.
Journal of Cell Science | Year: 2014
The evolutionarily conserved family of Bucentaur (BCNT) proteins exhibits a widespread distribution in animal and plants, yet its biological role remains largely unknown. Using Drosophila melanogaster as a model organism, we investigated the in vivo role of the Drosophila BCNT member called YETI. We report that loss of YETI causes lethality before pupation and defects in higherorder chromatin organization, as evidenced by severe impairment in the association of histone H2A.V, nucleosomal histones and epigenetic marks with polytene chromosomes. We also find that YETI binds to polytene chromosomes through its conserved BCNT domain and interacts with the histone variant H2A.V, HP1a and Domino-A (DOM-A), the ATPase subunit of the DOM/Tip60 chromatin remodeling complex. Furthermore, we identify YETI as a downstream target of the Drosophila DOM-A. On the basis of these results, we propose that YETI interacts with H2A.Vexchanging machinery, as a chaperone or as a new subunit of the DOM/Tip60 remodeling complex, and acts to regulate the accumulation of H2A.V at chromatin sites. Overall, our findings suggest an unanticipated role of YETI protein in chromatin organization and provide, for the first time, mechanistic clues on how BCNT proteins control development in multicellular organisms. © 2014. Published by The Company of Biologists Ltd.
PubMed | SSD Diabetologia e Malattie del Metabolismo, University of Verona, University of Rome Tor Vergata, National Research Council Italy and 24 more.
Type: | Journal: Clinical nutrition (Edinburgh, Scotland) | Year: 2016
The role of polyphenol intake on cardiovascular risk factors is little explored, particularly in people with diabetes.To evaluate the association between the intake of total polyphenols and polyphenol classes with the major cardiovascular risk factors in a population with type 2 diabetes.Dietary habits were investigated in 2573 males and females participants of the TOSCA.IT study. The European Prospective Investigation on Cancer and Nutrition (EPIC) questionnaire was used to assess dietary habits. In all participants, among others, we assessed anthropometry, plasma lipids, blood pressure, C-reactive protein and HbA1c following a standard protocol. The USDA and Phenol-Explorer databases were used to estimate the polyphenol content of the habitual diet.Average intake of polyphenols was 683.35.8mg/day. Flavonoids and phenolic acids were the predominant classes (47.5% and 47.4%, respectively). After adjusting for potential confounders, people with the highest intake of energy-adjusted polyphenols (upper tertile) had a more favorable cardiovascular risk factors profile as compared to people with the lowest intake (lower tertile) (BMI was 30.7 vs 29.9kg/mPolyphenol intake is associated with a more favorable cardiovascular risk factors profile, independent of major confounders. These findings support the consumption of foods and beverages rich in different classes of polyphenols particularly in people with diabetes.http://www.clinicaltrials.gov; Study ID number: NCT00700856.
Buono D.,University of Salerno |
Nocerino G.,Trenitalia Spa |
Solimeno S.,UniversitaFederico II |
Porzio A.,CNR Institute of Neuroscience
Laser Physics | Year: 2014
Entanglement, one of the most intriguing aspects of quantum mechanics, marks itself into different features of quantum states. For this reason different criteria can be used for verifying entanglement. In this paper we review some of the entanglement criteria casted for continuous variable states and link them to peculiar aspects of the original debate on the famous Einstein-Podolsky-Rosen (EPR) paradox. We also provide a useful expression for valuating Bell-type non-locality on Gaussian states. We also present the experimental measurement of a particular realization of the Bell operator over continuous variable entangled states produced by a sub-threshold type-II optical parametric oscillators (OPOs). © 2014 Astro Ltd.
Fiore G.,UniversitaFederico II |
Fiore G.,National Institute of Nuclear Physics, Italy
Journal of Physics A: Mathematical and Theoretical | Year: 2014
We revisit the exact microscopic equations (in differential, and equivalent integral form) ruling a relativistic cold plasma after the plane-wave Ansatz, without customary approximations. We show that in the Eulerian description the motion of a very diluted plasma initially at rest and excited by an arbitrary transverse plane electromagnetic travelling-wave has a very simple and explicit dependence on the transverse electromagnetic potential; for a non-zero density plasma the above motion is a good approximation of the real one as long as the back-reaction of the charges on the electromagnetic field can be neglected, i.e. for a time lapse decreasing with the plasma density, and can be used as initial step in an iterative resolution scheme. As one of many possible applications, we use these results to describe how the ponderomotive force of a very intense and short plane laser pulse hitting normally the surface of a plasma boosts the surface electrons into the ion background. In response to this penetration, the electrons are pulled back by the electric force exerted by the ions and the other displaced electrons and may leave the plasma with high energy in the direction opposite to that of propagation of the pulse 'slingshot effect' (Fiore G et al 2013 arXiv:1309.1400). © 2014 IOP Publishing Ltd.
De Angelis S.,Applicate |
De Angelis S.,UniversitaFederico II |
Della Corte V.,Applicate |
Baratta G.A.,National institute for astrophysics |
And 5 more authors.
Spectroscopy Letters | Year: 2011
Raman analyses have been performed on Interplanetary Dust Particles (IDPs) collected in the lower stratosphere by NASA high-flying aircrafts, dust from comet 81P/Wild2 collected by Stardust mission, and three particles collected in the upper stratosphere by the balloon-borne DUSTER instrument. All samples contain amorphous carbon (aC) with different degrees of structural order. Fe oxides were detected in the IDPs, aliphatic chains were found in comet grains, and three particles collected in the upper stratosphere are calcium carbonate (calcite or aragonite). Raman spectroscopy is a valuable tool for the nondestructive analyses of micrometer-scale constituents of complex natural materials. Copyright © Taylor & Francis Group, LLC.
Dellagreca M.,UniversitaFederico II |
Previtera L.,UniversitaFederico II |
Zarrelli A.,UniversitaFederico II
Natural Product Research | Year: 2010
The fresh leaves and twigs of Oxalis pes-caprae were crumbled and extracted with ethyl acetate and methanol. The extracts were fractionated by chromatographic procedures, followed by structure elucidation using mass spectrometry and 1H- and 13C-NMR spectroscopy and a new phenyl cinnamate derivative was identified, along with some known compounds. © 2010 Taylor & Francis.
Paduano F.,UniversitaMagna Graecia |
Dattilo V.,UniversitaMagna Graecia |
Narciso D.,UniversitaMagna Graecia |
Bilotta A.,UniversitaMagna Graecia |
And 8 more authors.
FEBS Journal | Year: 2013
Expression of PTPRJ, which is a ubiquitous receptor-type protein tyrosine phosphatase, is significantly reduced in a vast majority of human epithelial cancers and cancer cell lines (i.e. colon, lung, thyroid, mammary and pancreatic tumours). A possible role for microRNAs (miRNAs) in the negative regulation of PTPRJ expression has never been investigated. In this study, we show that overexpression of microRNA-328 (miR-328) decreases PTPRJ expression in HeLa and SKBr3 cells. Further investigations demonstrate that miR-328 acts directly on the 3′UTR of PTPRJ, resulting in reduced mRNA levels. Luciferase assay and site-specific mutagenesis were used to identify a functional miRNA response element in the 3′UTR of PTPRJ. Expression of miR-328 significantly enhances cell proliferation in HeLa and SKBr3 cells, similar to the effects of downregulation of PTPRJ with small interfering RNA. Additionally, in HeLa cells, the proliferative effect of miR-328 was not observed when PTPRJ was silenced with small interfering RNA; conversely, restoration of PTPRJ expression in miR-328-overexpressing cells abolished the proliferative activity of miR-328. In conclusion, we report the identification of miR-328 as an important player in the regulation of PTPRJ expression, and we propose that the interaction of miR-328 with PTPRJ is responsible for miR-328-dependent increase of epithelial cell proliferation. © 2012 The Authors Journal compilation © 2012 FEBS.