Pavia, Italy
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Berti P.,University of Modena and Reggio Emilia | Pratelli L.,Accademia Navale di Livorno | Rigo P.,Universita Of Pavia
Advances in Intelligent Systems and Computing | Year: 2017

Let (Xn) be a sequence of random variables, adapted to a filtration (Gn), and let μn = (1/n) ∑n i =1 δXi and an(・) = P(Xn +1∈ ・ | Gn) be the empirical and the predictive measures. We focus on ||μn − an|| = supB ∈D |μn(B) − an(B)|, where D is a class of measurable sets. Conditions for ||μn − an|| → 0, almost surely or in probability, are given. Also, to determine the rate of convergence, the asymptotic behavior of rn ||μn − an|| is investigated for suitable constants rn. Special attention is paid to rn = √n. The sequence (Xn) is exchangeable or, more generally, conditionally identically distributed. © Springer International Publishing Switzerland 2017.


Pereira J.B.,University of Leeds | Pereira J.B.,University of Porto | Costa M.D.,University of Leeds | Costa M.D.,University of Porto | And 19 more authors.
Proceedings of the Royal Society B: Biological Sciences | Year: 2017

Important gaps remain in our understanding of the spread of farming into Europe, due partly to apparent contradictions between studies of contemporary genetic variation and ancient DNA. It seems clear that farming was introduced into central, northern, and eastern Europe from the south by pioneer colonization. It is often argued that these dispersals originated in the Near East, where the potential source genetic pool resembles that of the early European farmers, but clear ancient DNA evidence from Mediterranean Europe is lacking, and there are suggestions that Mediterranean Europe may have resembled the Near East more than the rest of Europe in the Mesolithic. Here, we test this proposal by dating mitogenome founder lineages from the Near East in different regions of Europe. We find that whereas the lineages date mainly to the Neolithic in central Europe and Iberia, they largely date to the Late Glacial period in central/eastern Mediterranean Europe. This supports a scenario in which the genetic pool of Mediterranean Europe was partly a result of Late Glacial expansions from a Near Eastern refuge, and that this formed an important source pool for subsequent Neolithic expansions into the rest of Europe. ©2017 The Author(s) Published by the Royal Society. All rights reserved.


Liberale C.,Italian Institute of Technology | Cojoc G.,Max Planck Institute of Molecular Cell Biology and Genetics | Rajamanickam V.,Italian Institute of Technology | Ferrara L.,Italian Institute of Technology | And 7 more authors.
Springer Series in Surface Sciences | Year: 2015

Optical tweezers represent a powerful tool for a variety of applications both in biology and in physics, and their miniaturization and full integration is of great interest so as to reduce size (towards portable systems), and to minimize the required intervention from the operator. Optical fibers represent a natural solution to achieve this goal, and here we review the realization of single-fiber optical tweezers able to create a purely optical three-dimensional trap. © Springer International Publishing Switzerland 2015.


Tosi D.,University of Limerick | Macchi E.G.,Universita Of Pavia | Gallati M.,Universita Of Pavia | Braschi G.,Universita Of Pavia | And 4 more authors.
Biomedical Optics Express | Year: 2014

A linearly chirped fiber Bragg grating (LCFBG) has been used as a temperature sensor for online monitoring of radiofrequency thermal ablation (RFTA). The LCFBG acts as a distributed sensor, with spatial resolution of 75 μm. A white-light setup that records the LCFBG spectrum estimates the temperature profile in real time. Three RFTA experiments have been performed ex-vivo on porcine liver measuring the radial temperature distribution during the heating process. The analysis of thermal maps quantifies the spatial heat distribution along the measurement axis and determines the ablation efficiency. ©2013 Optical Society of America.


Pinto F.,Marcianise Hospital | Valentino M.,S Antonio Abate Hospital | Romanini L.,Universita Of Pavia | Basilico R.,Universita Of Chieti | Miele V.,UOC di Diagnostica per Immagini Cardiovascolare e d'Urgenza
Radiologia Medica | Year: 2014

Computed tomography (CT) still represents the preferred imaging method in the assessment of patients presenting with multiple trauma. Nevertheless, in patients with low-energy abdominal trauma, the use of CT is debated because of the possible unnecessary radiation exposure. Accordingly, conventional ultrasound (US) imaging has been increasingly employed as the initial imaging modality in the workup of minor traumatic emergency conditions. Focused assessment with sonography for trauma is widely used to detect free intra-abdominal fluid, but its role is controversial, because the absence of free fluid does not exclude the presence of injuries to abdominal organ. Injection of an ultrasound contrast agent (UCA) may give the radiologist relevant additional information to that obtained with conventional US. Thus, in trauma patients, following early assessment with conventional US imaging, a contrast-enhanced US (CEUS) can provide a more reliable evaluation of solid organ injuries and related vascular complications, including active bleeding, pseudoaneurysms, and artero-venous fistulas. CEUS cannot replace abdominal CT, but it represents a noninvasive and repeatable imaging tool capable of providing a reliable assessment of trauma severity and expedite the patient’s treatment. © 2014, Italian Society of Medical Radiology.


Heard M.E.,University of Arkansas for Medical Sciences | Besio R.,University of Arkansas for Medical Sciences | Besio R.,Universita Of Pavia | Weis M.,University of Washington | And 14 more authors.
PLoS Genetics | Year: 2016

Collagen is a major component of the extracellular matrix and its integrity is essential for connective tissue and organ function. The importance of proteins involved in intracellular collagen post-translational modification, folding and transport was recently highlighted from studies on recessive forms of osteogenesis imperfecta (OI). Here we describe the critical role of SC65 (Synaptonemal Complex 65, P3H4), a leprecan-family member, as part of an endoplasmic reticulum (ER) complex with prolyl 3-hydroxylase 3. This complex affects the activity of lysyl-hydroxylase 1 potentially through interactions with the enzyme and/or cyclophilin B. Loss of Sc65 in the mouse results in instability of this complex, altered collagen lysine hydroxylation and cross-linking leading to connective tissue defects that include low bone mass and skin fragility. This is the first indication of a prolyl-hydroxylase complex in the ER controlling lysyl-hydroxylase activity during collagen synthesis. © 2016 Heard et al.

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