Bab Taza, Morocco
Bab Taza, Morocco

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Hadda T.B.,University Mohammed Premier | Fathi J.,University Mohammed Premier | Chafchaouni I.,Universiapolis | Masand V.,Vidya Bharati College | And 4 more authors.
Medicinal Chemistry Research | Year: 2013

A computation model has been developed for the rational design of bioactive pharmacophore sites as anti-viral candidates based on available X-ray structures of drugs. The compounds have been previously screened for anti-viral activity against HIV-Integrase (HIV IN). Amongst the series, the most potent compounds, 4k and 4d (low μM IC50) were tested in viral cultures for their ability to present potentials (O 1 δ- -O 2 δ- -O 3 δ-) for anti-viral pharmacophore site but represent a potential risk of toxicity. Furthermore, the compounds 4k and 4d showed potent anti-HIV IN activity. A good correlation was obtained between the theoretical predictions of bioavailability using POM suite (Petra/Osiris/Molinspiration containing Lipinski's rule-of-five) and experimental verification. The structure-activity relationships were also analyzed to vindicate the POM results. Graphical abstract: A series of known anti-HIV agents; the amide-containing diketoacids were POM and 3D-QSAR analyzed in goal to understand and develop more potent/selective HIV IN inhibitors. Their inhibition of HIV IN was attributed to them containing O1,O 2,O4-pharmacophore site. The structure-activity relationships were discussed on the basis of POM analyses.[Figure not available: see fulltext.] © 2012 Springer Science+Business Media, LLC.


Lococo D.,University Claude Bernard Lyon 1 | Lococo D.,CNRS Automation and Process Engineering Laboratory | Mora-Huertas C.E.,University Claude Bernard Lyon 1 | Mora-Huertas C.E.,CNRS Automation and Process Engineering Laboratory | And 5 more authors.
Journal of Biomedical Nanotechnology | Year: 2012

This research work deals with the development of argan oil-based nanoemulsions as vehicle of hydrophobic drugs such as diclofenac used as model. Nanoemulsions of oil in water were prepared using the ultrasonication method in order to obtain submicron size colloidal dispersion. The size, zeta potential and encapsulation efficiency of the dispersions obtained were investigated. In addition, the ability of sorbitan ester derivatives to form nanovesicles (niosomes), which in turn were used for encapsulating drug in oily solutions forming stable nanoemulsions, was particularly examined. Thus, additional stabilizing agents were not required in the recipe and formulations using only sorbitan monolaurate, argan oil and water lead to attractive results. Their submicronic size (<250 nm), high negative zeta potential (between -40 and -50 mV) and drug-encapsulation efficiency (higher than 85%) allow predicting both a good physical stability and a good performance as drug carriers. Copyright © 2012 American Scientific Publishers All rights reserved.


Addi E.H.A.,Equipe de recherche de Biotechnologie | Zaanoun I.,Equipe de recherche de Biotechnologie | Zaanoun I.,Universiapolis | Addi A.A.,Equipe de recherche de Biotechnologie | And 3 more authors.
International Journal of Electrochemical Science | Year: 2013

The corrosion behaviour of tinplate in a synthetic medium similar to industrial water containing sulphates, chlorides and HCO3 - ions has been studied. The effect of concentration of anions in solution has been investigated. The results obtained by use of electrochemical and metalographical techniques show that tinplate manifests a passivation phenomenon with rupture of passivity. The examination of the spectra obtained by microanalysis EDAX shows the presence of the chemical elements Sn, Fe and O2 on the surface of tinplate but with proportions which depend on the state of material. The results obtained show that tinplate is very sensitive to the anions concentration variation in solution. The presence of anions Cl- and SO4 2- stimulate pitting corrosion of tinplate, whereas HCO3 - ions acted as an inhibitor for pitting corrosion of this material in the studied medium. © 2013 by ESG.


PubMed | COMSAT Institute, Universiapolis, University Claude Bernard Lyon 1, National University of Sciences and Technology and State University of Maringá
Type: | Journal: Colloids and surfaces. B, Biointerfaces | Year: 2016

Aminodextran (AMD) polymer was prepared via chemical grafting of hexamethylenediamine on oxidized dextran. Magnetic latex particles were successfully obtained by adsorption of positively charged AMD on negatively charged submicron magnetic emulsion. The adsorbed amount was found to be ranged from 20 to 1280mg of AMD per gram of dried magnetic dispersion. The AMD-coated magnetic emulsions were characterized by positive zeta potential in the pH range from 3 to 9 compared to bare seed magnetic emulsion. All the samples showed to be superparamagnetic property, even after the adsorption of the polymer. The developed magnetic submicron particles exhibited good potential for in vivo biomedical diagnosis applications as demonstrated by their higher T2 contrast-ability compared to Gd in magnetic resonance imaging (MRI) and hyperthermia.


PubMed | Universiapolis, CNRS Automation and Process Engineering Laboratory and Autonomous University of Nuevo León
Type: Journal Article | Journal: Expert opinion on drug delivery | Year: 2016

Plants are a natural source of various products with diverse biological activities offering treatment for several diseases. Plant extract is a complex mixture of compounds, which can have antioxidant, antibiotic, antiviral, anticancer, antiparasitic, antifungal, hypoglycemic, anti-hypertensive and insecticide properties. The extraction of these extracts requires the use of organic solvents, which not only complicates the formulations but also makes it difficult to directly use the extracts for humans. To overcome these problems, recent research has been focused on developing new ways to formulate the plant extracts and delivering them safely with enhanced therapeutic efficacy.This review focuses on the research done in the development and use of polymeric nanoparticles for the encapsulation and administration of plant extracts. It describes in detail, the different encapsulation techniques, main physicochemical characteristics of the nanoparticles, toxicity tests and results obtained from in vivo or in vitro assays.Major obstacles associated with the use of plant extracts for clinical applications include their complex composition, toxicity risks and extract instability. It is observed that encapsulation can be successfully used to decrease plant extracts toxicity, to provide targeted drug delivery and to solve stability related problems.


PubMed | Universiapolis, CNRS Automation and Process Engineering Laboratory, University Claude Bernard Lyon 1 and State University of Maringá
Type: | Journal: Materials science & engineering. C, Materials for biological applications | Year: 2016

Magnetic particles are of great interest in various biomedical applications, such as, sample preparation, in vitro biomedical diagnosis, and both in vivo diagnosis and therapy. For in vitro applications and especially in labs-on-a-chip, microfluidics, microsystems, or biosensors, the needed magnetic dispersion should answer various criteria, for instance, submicron size in order to avoid a rapid sedimentation rate, fast separations under an applied magnetic field, and appreciable colloidal stability (stable dispersion under shearing process). Then, the aim of this work was to prepare highly magnetic particles with a magnetic core and conducting polymer shell particles in order to be used not only as a carrier, but also for the in vitro detection step. The prepared magnetic seed dispersions were functionalized using pyrrole and pyrrole-2-carboxylic acid. The obtained core-shell particles were characterized in terms of particle size, size distribution, magnetization properties, FTIR analysis, surface morphology, chemical composition, and finally, the conducting property of those particles were evaluated by cyclic voltammetry. The obtained functional submicron highly magnetic particles are found to be conducting material bearing function carboxylic group on the surface. These promising conducting magnetic particles can be used for both transport and lab-on-a-chip detection.


Chafchaouni-Moussaoui I.,Universiapolis | Charrouf Z.,University Mohammeddal | Guillaume D.,French National Center for Scientific Research
Natural Product Communications | Year: 2013

During the last two decades, the argan tree has been the subject of intensive phytochemical investigation. If argan oil is the most known argan derivative, argan saponins are frequently considered as molecules presenting a strong economic potential. This review presents an update of the current research efforts on argan saponins from around the world. Research evidence suggests that arganine C can be considered as a lead compound for new antivirals.


Massaq A.,Caddi Ayad University | Rusinek A.,University of Lorraine | Klosak M.,Universiapolis | Klosak M.,Wrocław University | And 2 more authors.
Tribology International | Year: 2016

The Hopkinson Split Pressure Bar system allows to carry out compression tests at high impact velocities corresponding to high strain rates up to 5000 s-1. For composite materials, however, negative phenomena related to wave propagation and specimen geometry may disturb experimental analysis and, therefore, should be taken into account. Potential errors are mainly due to friction, inertia and wave dispersion. In order to provide a complete analysis of experimental results for composite materials under dynamic compression, a procedure was developed to estimate friction and dispersion effects at the specimen-bar contact zone. For this purpose, dynamic tests were carried out on woven glass-fiber-reinforced Polyamide (PA6) composites using Hopkinsons bar and pin-on-disk tribometer tests techniques. Results showed that the state of friction characterizing the PA6/glass material differs as per the orientation of fibers. The frictional regime is relatively more severe in case where the fibers are normal to the direction of friction. © 2016 Elsevier Ltd.


Mifdal L.,University of Lorraine | Mifdal L.,Universiapolis | Hajej Z.,University of Lorraine | Dellagi S.,University of Lorraine
Mathematical Problems in Engineering | Year: 2015

This paper deals with the problem of maintenance and production planning for randomly failing multiple-product manufacturing system. The latter consists of one machine which produces several types of products in order to satisfy random demands corresponding to every type of product. At any given time, the machine can only produce one type of product and then switches to another one. The purpose of this study is to establish sequentially an economical production plan and an optimal maintenance strategy, taking into account the influence of the production rate on the system's degradation. Analytical models are developed in order to find the production plan and the preventive maintenance strategy which minimizes sequentially the total production/inventory cost and then the total maintenance cost. Finally, a numerical example is presented to illustrate the usefulness of the proposed approach. © 2015 Lahcen Mifdal et al.


Amine M.E.,Universiapolis | Perry N.,Arts et Metiers ParisTech | Pailhes J.,Arts et Metiers ParisTech
International Journal on Interactive Design and Manufacturing | Year: 2016

The presence of immature concepts makes difficult decision making at upstream phase of a development project. Rework tasks in collaborative development projects dealing with immature design concepts are very frequent and are responsible of cost overruns and schedule delays. In addition, decisions taken during conceptual design stage have the most important influence on product life cycle cost. In this context, a useful practice is to develop two or more concepts in parallel and delay decision making. Even so, a first screening of concepts is usually needed because of the substantial resources and time required in development phase. In this paper, an approach of concepts screening is proposed at conceptual design phase on the basis of two metrics. The first assesses ability of concepts to meet requirements with integration of maturity. Fuzzy logic tools are used to capture and propagate imprecision in embodiment design choices and behavior models. The second metric aims to assess expected performance of novel concepts compared with an existent product. It uses generalized ordered weighted averaging operator. A parametric aggregation function is also proposed as a support when using the two metrics. The proposed approach was applied to the development of a solar collector. © 2016 Springer-Verlag France

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