Units of Endocrinology and Metabolic Diseases

Milano, Italy

Units of Endocrinology and Metabolic Diseases

Milano, Italy

Time filter

Source Type

Zhukouskaya V.V.,Units of Endocrinology and Metabolic Diseases | Zhukouskaya V.V.,University of Milan | Ellen-Vainicher C.,Units of Endocrinology and Metabolic Diseases | Ellen-Vainicher C.,University of Milan | And 19 more authors.
Osteoporosis International | Year: 2016

Summary: The objective of the study was to evaluate the usefulness of trabecular bone score (TBS) and bone mineral density (BMD) for identifying vertebral fractures (VFx) in well-compensated type 2 diabetic (T2D) patients. TBS and femoral neck BMD below certain cutoffs may be useful for identifying VFx in well-compensated T2D patients. Introduction: In T2D, the prevalence of VFx is increased, especially in poorly compensated and complicated diabetic patients. The possibility of predicting the fracture risk in T2D patients by measuring BMD and TBS, an indirect parameter of bone quality, is under debate. Therefore, the objective was to evaluate the usefulness of TBS and BMD for identifying VFx in well-compensated T2D patients. Methods: Ninety-nine T2D postmenopausal women in good metabolic control (glycosylated haemoglobin 6.8 ± 0.7 %) and 107 control subjects without T2D were evaluated. In all subjects, we evaluated the following: the BMD at the lumbar spine (LS) and the femoral neck (FN); the TBS by dual X-ray absorptiometry; and VFx by radiography. In T2D subjects, the presence of diabetic retinopathy, neuropathy, and nephropathy was evaluated. Results: T2D subjects had increased VFx prevalence (34.3 %) as compared to controls (18.7 %) (p = 0.01). T2D subjects presented higher BMD (LS −0.8 ± 1.44, FN −1.06 ± 1.08), as compared to controls (LS −1.39 ± 1.28, p = 0.002; FN −1.45 ± 0.91, p = 0.006, respectively). TBS was not different between diabetics and controls. In fractured T2D patients, LS-BMD, FN-BMD, and TBS were reduced (−1.2 ± 1.44; −1.44 ± 1.04; 1.072 ± 0.15) and the prevalence of retinopathy (15.4 %) was increased than in nonfractured T2D subjects (−0.59 ± 1.4, p = 0.035; −0.87 ± 1.05, p = 0.005; 1.159 ± 0.15, p = 0.006; 1.8 %, p = 0.04, respectively). The combination of TBS ≤1.130 and FN-BMD less than −1.0 had the best diagnostic accuracy for detecting T2D fractured patients (SP 73.8 %, SN 63.6 %, NPV 78.9 %, PPV 56.8 %). Conclusions: TBS and FN-BMD below certain cutoffs may be useful for identifying VFx in well-compensated T2D patients. © 2015, International Osteoporosis Foundation and National Osteoporosis Foundation.


PubMed | University of Catania, Units of Endocrinology and Metabolic Diseases and Units of Nuclear Medicine
Type: Journal Article | Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | Year: 2016

The objective of the study was to evaluate the usefulness of trabecular bone score (TBS) and bone mineral density (BMD) for identifying vertebral fractures (VFx) in well-compensated type 2 diabetic (T2D) patients. TBS and femoral neck BMD below certain cutoffs may be useful for identifying VFx in well-compensated T2D patients.In T2D, the prevalence of VFx is increased, especially in poorly compensated and complicated diabetic patients. The possibility of predicting the fracture risk in T2D patients by measuring BMD and TBS, an indirect parameter of bone quality, is under debate. Therefore, the objective was to evaluate the usefulness of TBS and BMD for identifying VFx in well-compensated T2D patients.Ninety-nine T2D postmenopausal women in good metabolic control (glycosylated haemoglobin 6.80.7 %) and 107 control subjects without T2D were evaluated. In all subjects, we evaluated the following: the BMD at the lumbar spine (LS) and the femoral neck (FN); the TBS by dual X-ray absorptiometry; and VFx by radiography. In T2D subjects, the presence of diabetic retinopathy, neuropathy, and nephropathy was evaluated.T2D subjects had increased VFx prevalence (34.3 %) as compared to controls (18.7 %) (p=0.01). T2D subjects presented higher BMD (LS -0.81.44, FN -1.061.08), as compared to controls (LS -1.391.28, p=0.002; FN -1.450.91, p=0.006, respectively). TBS was not different between diabetics and controls. In fractured T2D patients, LS-BMD, FN-BMD, and TBS were reduced (-1.21.44; -1.441.04; 1.0720.15) and the prevalence of retinopathy (15.4 %) was increased than in nonfractured T2D subjects (-0.591.4, p=0.035; -0.871.05, p=0.005; 1.1590.15, p=0.006; 1.8 %, p=0.04, respectively). The combination of TBS 1.130 and FN-BMD less than -1.0 had the best diagnostic accuracy for detecting T2D fractured patients (SP 73.8 %, SN 63.6 %, NPV 78.9 %, PPV 56.8 %).TBS and FN-BMD below certain cutoffs may be useful for identifying VFx in well-compensated T2D patients.

Loading Units of Endocrinology and Metabolic Diseases collaborators
Loading Units of Endocrinology and Metabolic Diseases collaborators