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Allahābād, India

Mishra S.B.,United Institute of Pharmacy | Pandey H.,Allahabad University | Pandey A.C.,Allahabad University
Advances in Natural Sciences: Nanoscience and Nanotechnology | Year: 2013

Phyllanthus amarus (P. amarus) is commonly used for traditional Indian medicine and as dietary adjuncts for the treatment of numerous physiological disorders including hepatic disorders. Due to the poor water solubility of its major constituents such as lignans and flavonoids, its absorption upon oral administration could be limited. The present study was designed to evaluate and compare the hepatoprotective effects of the ethanolic extract of P. amarus (PAE) and its nanoparticles (PAN) on paracetamol induced acute liver toxicity in Sprague-Dawley rats. An oral dose of PAE at 125 and 250 mg kg-1 and PAN at 25 and 50 mg kg-1 showed a significant hepatoprotective effect relatively to the same extent (P < 0.001) by reducing levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bile salts. These biochemical assessments were supported by rat hepatic biopsy examinations. Moreover, the results also indicated that the hepatoprotective effect of 50 mg kg-1 PAN was effectively better than 125 mg kg -1 PAE (P < 0.001), and an oral dose of PAN that is five times less than PAE could exhibit similar levels of outcomes. In conclusion, we suggest that the nanoparticles system can be applied to overcome other poorly water soluble herbal medicines and furthermore to decrease the treatment dosage. © 2013 Vietnam Academy of Science & Technology. Source

Pandey P.,United Institute of Pharmacy | Singh J.,Allahabad University
Der Pharma Chemica | Year: 2014

2-Amino-4-aryl thiazoles and their derivatives have long been used as precursors for the synthesis of biologically active molecules. Therefore new antifungal compounds IV(a-e) have been synthesized incorporating 2-Amino-4-aryl thiazole. The title compounds were synthesized through isolable intermediates. All the synthesized compounds have been characterized by their elemental analysis, 1HNMR and Mass spectra. The synthesized compounds were evaluated in vitro for their antifungal activity against the test fungi by poisoned food technique; at 1000, 100 and 10 ppm using Czapek's agar medium. A standard commercial fungicide Dithane M-45 was also tested under similar conditions for comparison. It was found that all the compounds were antifungal active but amongst them IVd displayed fungicidal action comparable with that of commercial fungicide Dithane M-45. Source

Das T.,Girijananda Chowdhury Institute of Pharmaceutical Science | Das B.,Government Ayurvedic College | Saha D.,Girijananda Chowdhury Institute of Pharmaceutical Science | Mishra S.B.,United Institute of Pharmacy
Journal of Applied Pharmaceutical Science | Year: 2015

Objective: The primary objective of the present investigation is to evaluate the antihyperglycemic activity of the 50% ethanolic extract of the Tecomella undulata Seem. (TUE) bark in the streptozotocin induced diabetic rats. Methods: Single intraperitoneal injection (i.p.) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes is wistar albino rats. The induction of diabetes was confirmed after 3 days after STZ injection and rats with fasting blood glucose levels greater than 200 mg/dl were considered to be diabetic used in the experiment. TUE at a once a daily dose of 250 mg/kg, and 500 mg/kg, p.o. along with glibenclamide 600μg/kg, p.o. was also given for 21 days. On the 21st day rats from all the groups fasted overnight and the blood was collected from the puncturing the retro orbit of the eye under mild ether anesthetic condition. The oral acute toxicity studies did not show any toxic effect till the dose at 2000 mg/kg. Results: The statistical data indicated that the different doses of the TUE significantly decreases the level of fasting blood glucose, total cholesterol, triglycerides, low density lipoprotein and increase high density lipoprotein in STZ induced diabetic rats. This result indicated that T. undulata extract can protect pancreatic ß-cells from STZ-induced damage which is confirmed by the results of the histopathological examination of the pancreas. Conclusion: Our investigation has clearly indicated that the bark extract of Tecomella undulata Seem. showed remarkable antihyperglycemic activity due to its possible systematic effect involving in the pancreatic and extra pancreatic mechanism. Moreover, the antihyperlipidemic activity was exerted possible by lowering the higher level of lipid profile. © 2015 Trishna Das et al. Source

Ahmed D.,Sam Higginbottom Institute of Agriculture, Technology and Sciences | Sharma M.,Jamia Hamdard University | Mukerjee A.,United Institute of Pharmacy | Ramteke P.W.,Sam Higginbottom Institute of Agriculture, Technology and Sciences | Kumar V.,Sam Higginbottom Institute of Agriculture, Technology and Sciences
BMC Complementary and Alternative Medicine | Year: 2013

Background: The present study was undertaken to evaluate the antihyperglycemic, antihyperlipidemic and hepatoprotective effect of a traditional unani formulation " Qurs Tabasheer" in streptozotocin (STZ) induced diabetic wistar rats. Up till now no study was undertaken to appraise the efficacy of " Qurs Tabasheer" in the diabetic rats. Qurs Tabasheer is a unani formulation restraining preparations from five various herbs namely Tukhme Khurfa (Portulaca oleracea seed), Gule Surkh (Rosa damascena flower), Gulnar (Punica granatum flower), Tabasheer (Bambusa arundinasia dried exudate on node), Tukhme Kahu (Lactuca sativa Linn seed).Methods: Effect of Qurs Tabasheer was assessed in STZ (60 mg/kg, i.p single shot) induced diabetic wistar rats. STZ produced a marked increase in the serum glucose, Total Cholesterol, LDL cholesterol, VLDL Cholesterol, Triglycerides and trim down the HDL level. We have weighed up the effect of Qurs Tabasheer on hepatic activity through estimating levels of various liver enzymes viz. Hexokinase, Glucose-6-Phosphatase and Fructose-1-6-biphosphatase in STZ diabetic wistar rats.Results: In STZ-induced diabetic wistar rats level of Hexokinase, and Glucose-6-Phosphatase was decreased to a significant level while the level of fructose-1-6-biphophatase was augmented. Therapy with Qurs Tabasheer for 28 days to STZ-induced diabetic rats significantly reduces the level of serum glucose, total cholesterol, triglycerides, glucose-6-phosphatase and fructose-1-6-biphosphatase, while magnitude of HDL cholesterol and hexokinase was amplified.Conclusion: Antihyperglycemic, antihyperlipidemic activity of Qurs Tabasheer extract in STZ- induced wistar rats was found to be more effective than standard oral hypoglycemic drug Glimepiride. © 2013 Ahmed et al.; licensee BioMed Central Ltd. Source

Saha D.,Girijananda Chowdhury Institute of Pharmaceutical Science | Ghosh S.K.,Dibrugarh University | Das T.,Girijananda Chowdhury Institute of Pharmaceutical Science | Mishra S.B.,United Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: To investigate the hypoglycemic and antihyperlipidemic effect of a successive ethanolic extract of Adiantum caudatum (EEAC) whole plant in alloxan induced diabetic rats. Methods: Diabetes was induced in Wistar albino rats by the administration of alloxan (140 mg/kg b. w., i.p.). EEAC (200 mg/kg b. w., p.o.) was administered to diabetic rats for 21 days in alloxan induced diabetic rats. The effect of EEAC on blood glucose and body weight was studied in alloxan induced diabetic rats. All these effects were compared with glibenclamide (10 mg/kg b. w., p.o.) as a reference antidiabetic drug. Results: The administration of EEAC (200 mg/kg b. w., p.o.) resulted in a significant decrease in blood glucose level and a significant increase in body weight in alloxan induced diabetic rats. Furthermore, EEAC showed antihyperlipidemic activity as evidenced by a significant decrease in serum total cholesterol and triglyceride levels in alloxan induced diabetic rats. Conclusion: The results suggest that the EEAC possess a promising hypoglycemic effect in alloxan induced diabetic rats. © 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved. Source

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