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Allen W.J.,Virginia Polytechnic Institute and State University | Capelluto D.G.S.,United Domains | Finkielstein C.V.,State University | Bevan D.R.,Virginia Polytechnic Institute and State University
Journal of Physical Chemistry B | Year: 2010

Fifty percent of all cancer cases result from mutations of the TP53 gene, which encodes the tumor suppressor p53, and it is hypothesized that the p53-mediated checkpoint pathway is compromised in most of the remaining cases. The p53 C-terminal domain (CTD) is an important site of p53 regulation but by nature is difficult to study, as it is intrinsically disordered. In this study, we performed molecular dynamics simulations on the p53 CTD and five known regulatory binding partners. We identified distinct trends in fluctuation within and around the p53 CTD binding site on each partner demonstrating a behavior that facilitates association. Further, we present evidence that the size of the hydrophobic pocket in each p53 CTD binding site governs the secondary structure of the p53 CTD when in the bound state. This information will be useful for predicting new binding partners for the p53 CTD, identifying interacting regions within other known partners, and discovering inhibitors that provide additional points of control over p53 activity. © 2010 American Chemical Society. Source


United Domains | Entity website

Florian Huberverantwortet als CEO die Bereiche "Produkt" und "Technik" und sorgt mit seinem Team fr sichere, ausfallfreie und leicht zu bedienende Produkte


United Domains | Entity website

Florian Huberverantwortet als CEO die Bereiche "Produkt" und "Technik" und sorgt mit seinem Team fr sichere, ausfallfreie und leicht zu bedienende Produkte


United Domains | Entity website

Florian Huberverantwortet als CEO die Bereiche "Produkt" und "Technik" und sorgt mit seinem Team fr sichere, ausfallfreie und leicht zu bedienende Produkte


News Article | May 13, 2009
Site: gigaom.com

German magazine and digital publisher Hubert Burda Media is buying Lycos iQ, a question-and-answer community site that will be one of the final Lycos Europe assets to be offloaded. Despite failing to innovate to retain its once-mighty search engine status, the portal with the black dog logo had, over the last couple of years, routinely hailed the site – an imitation of Yahoo’s popular Answers counterpart – as one of its best homegrown projects. It currently has 750,000 users, but the UK version has gone off-line. A separate company from its US counterpart, Lycos Europe was unable to find a buyer last year so in December decided to liquidate instead. In asset-stripping, it’s managed to off-load its Jubii Denmark, United Domains and Shopping businesses, and even struck a deal to rescue Tripod from closure just days before a shutdown deadline. Next in the fire sale before the dog is put to sleep – the Pangora ecommerce network. Burda has extensive online operations under its Burda Digital Ventures wing, but the company, via Deutsche-Startups.de, says it wants to offer its mag editors’ knowledge to readers through Q&A. No price was disclosed.

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