Time filter

Source Type

Al Ain, United Arab Emirates

United Arab Emirates University was established in 1975 and is the first and oldest of the three government-sponsored institutions of higher learning in the United Arab Emirates . The university is located in Al Ain, United Arab Emirates. The UAEU is an accredited comprehensive research-based institution providing research solutions to support the UAE and, through its global partners, the wider world.The university admits UAE nationals primarily, with about 15% of its student body coming predominantly from other Gulf Cooperation Council countries. Wikipedia.

Bahi A.,United Arab Emirates University
Physiology and Behavior | Year: 2015

It is well established that oxytocin, and its receptor (OxtR), play a crucial role in addiction and that the stimulation of oxytocin neurotransmission reduces addictive behaviors to ethanol in laboratory animals. However, the impact of OxtR modulation on acquisition, extinction and reinstatement of drug-elicited ethanol-conditioned place preference (EtOH-CPP) has not yet been investigated. In this study, we evaluated the effects of OxtR pharmacological modulation, using the oxytocin analog Carbetocin, and genetic overexpression in the nucleus accumbens (NAcc), using lentiviral-mediated gene transfer technology, of the OxtR on acquisition, extinction and reinstatement of drug-elicited EtOH-CPP in mice. In the first experiment, results showed that Carbetocin administration and NAcc OxtR-overexpression (LV-OxtR) reduced EtOH-CPP establishment. In the second experiment, systemic Carbetocin treatment and OxtR overexpression resulted in decreased time spent in the ethanol-paired compartment following completion of a 7-day extinction protocol. Finally, the third experiment showed that Carbetocin and LV-OxtR suppressed primed reinstatement of EtOH-CPP. It is concluded that pharmacological and genetic modulation of the OxtR can modulate the acquisition, extinction, and reinstatement of conditioned reinforcing effects of ethanol. Taken together, the current findings add to the growing literature on oxytocin neurotransmission modulation in the pharmacotherapy of ethanol addiction and alcoholism. © 2013 Elsevier Inc.

Whether metabotropic glutamate 7 (mGluR7) -activation enhances or diminishes the reinforcing properties of psychostimulants remains unclear. We have previously shown that systemic mGluR7 activation reduced alcohol consumption and preference as well as locomotorstimulating and rewarding properties of ethanol. In this study, we further examined the contribution of mGluR7 on the effect of ethanol within the nucleus accumbens (NAcc), a neural target for many drugs of abuse. Using short hairpin RNA (shRNA)-expressing lentiviral vectors (LV) to alter locally the activity of mGluR7 in male rats, we have shown that blocking mGluR7 expression increased ethanol consumption and preference in a two-bottle choice drinking paradigm with no effect either on saccharin or on quinine used for taste discrimination. In addition, mGluR7 knockdown increases preference for environments previously paired with low doses of ethanol in the conditioned place preference (CPP) test, as it shifted the dose-response curve for ethanol CPP to the left, indicating alterations in the rewarding effects of alcohol. More importantly, mGluR7 blockade in the dorsal striatum (DS) neither affected ethanol consumption nor ethanol-elicited CPP. These results show that levels of mGluR7 in the NAcc regulate responsiveness to alcohol. Taken together, these findings clearly demonstrate that mGluR7 signaling within the NAcc is a key modulator of functional responses to ethanol and offer an important target for regulating the addictive effects of alcohol. © 2013 American College of Neuropsychopharmacology. All rights reserved.

Hamdan M.O.,United Arab Emirates University
Renewable Energy | Year: 2011

A simplified thermodynamics analytical model for steady airflow inside a solar chimney is performed. A simplified Bernoulli equation combined with fluid statics and ideal gas equation was implemented and solved using EES solver to predict the performance of the solar chimney power plant. The analytical model matched the experimental data and numerical study available in the literature. The developed analytical model was used to evaluate the effect of geometric parameters on the solar plant power generation. The analysis showed that chimney height and turbine pressure head are the most important physical variables for the solar chimney design. The study showed that second-law efficiency has non-monotonic relation with turbine pressure head. The model shows that second-law efficiency and power harvested increase with the increase of chimney height and/or diameter. The developed model is used to analyze the feasibility of solar chimney power plants for the UAE climate which possesses typical characteristics of the Gulf climate. The solar characteristics of the UAE are shown along with characteristic meteorological data. A solar chimney power plant with a chimney height of 500 m and a collector roof diameter of 1000 m would produce at least 8 MW of power. The amount of power produced during the summer would be higher where the demand in the Gulf area is the highest. © 2010 Elsevier Ltd.

Effects of various pretreatments of the anaerobic sludge on hydrogen production were investigated for enhancing hydrogen production via dark anaerobic fermentation of organic substrates. The pretreatment methods included heat treatment, acid or base treatment, acid/heat treatment and base/heat treatment. After the pretreatment of the anaerobic sludge, productivity of H 2 by the pretreated sludge were evaluated when the culture were grown on glucose-based medium at ambient conditions. The detailed experimental investigation showed highest production of H 2 by the heat-treated culture followed by the heat and acid-treated culture and the heat and base-treated culture. © 2012.

Radhi H.,United Arab Emirates University
Energy | Year: 2010

Buildings have direct and indirect impacts on the CO2 emissions. This paper presents a study on the impact of wall systems and cladding materials on the CO2 emissions and aims to analyse the performance of those systems in order to provide designers with reliable technical data. The studied systems include stucco, masonry veneer, aluminium siding, vinyl siding and the exterior insulation and finish systems (EIFS). To evaluate the economic performance, environmental performance and embodied energy, green building modelling system was used, while to estimate the impact of operational energy, a simulation model was first used and then simple bottom-up model constructed. A sensitivity analysis was conducted in order to determine the relative influence of each system on a representative educational building. It was found that some cladding materials reduce the direct CO2 emissions, but provide a moderate reduction in terms of operational energy, and vice versa. Others positively impact the embodied energy and environmental performance and can optimise the operational energy performance. Therefore, a careful evaluation should be carried out in selecting wall cladding systems and finishing materials in order to reduce the CO2 emissions effectively. © 2009 Elsevier Ltd. All rights reserved.

Discover hidden collaborations