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Dramane G.,Unite Propre de LEnseignement Superieure Lipides and Signalisation Cellulaire Equipe DAccueil 4183 | Dramane G.,University of Parakou | Akpona S.,University of Parakou | Simonin A.M.,Unite Propre de LEnseignement Superieure Lipides and Signalisation Cellulaire Equipe DAccueil 4183 | And 2 more authors.
Current Medicinal Chemistry | Year: 2011

It has been well propounded that there exists five basic taste modalities, e.g., sweet, sour, bitter, salty and umami. Recent compelling evidence from rodents and human beings raises the possibility for an additional sixth taste modality devoted to the perception of lipids. A number of studies have suggested that lingual CD36, a glycoprotein, mainly expressed by circumvallate papillae of the tongue, might be implicated in the perception of dietary fat taste. G protein-coupled receptors (GPCRs) are important signaling molecules for many aspects of cellular function. It has been recently shown that these receptors particularly GPR40 and GPR120 might also be involved in lipid taste perception. In this article, we highlight the cell activation mechanisms, responsible for the downstream cell signaling which might help understand the lipid-mediated regulation of feeding behavior, critically involved in the development of several diseases like obesity and other metabolic disorders. We also raise the question whether lipid gustatory cells can be the target of anti-obesity strategies. © 2011 Bentham Science Publishers Ltd. Source


Dramane G.,Unite Propre de LEnseignement Superieure Lipides and Signalisation Cellulaire Equipe DAccueil 4183 | Dramane G.,University of Parakou | Abdoul-Azize S.,Unite Propre de LEnseignement Superieure Lipides and Signalisation Cellulaire Equipe DAccueil 4183 | Abdoul-Azize S.,University Abdou Moumouni | And 9 more authors.
Journal of Clinical Investigation | Year: 2012

Understanding the mechanisms underlying oro-gustatory detection of dietary fat is critical for the prevention and treatment of obesity. The lipid-binding glycoprotein CD36, which is expressed by circumvallate papillae (CVP) of the mouse tongue, has been implicated in oro-gustatory perception of dietary lipids. Here, we demonstrate that stromal interaction molecule 1 (STIM1), a sensor of Ca 2+ depletion in the endoplasmic reticulum, mediates fatty acid-induced Ca 2+ signaling in the mouse tongue and fat preference. We showed that linoleic acid (LA) induced the production of arachidonic acid (AA) and lysophosphatidylcholine (Lyso-PC) by activating multiple phospholipase A 2 isoforms via CD36. This activation triggered Ca 2+ influx in CD36-positive taste bud cells (TBCs) purified from mouse CVP. LA also induced the production of Ca 2+ influx factor (CIF). STIM1 was found to regulate LA-induced CIF production and the opening of multiple store-operated Ca 2+ (SOC) channels. Furthermore, CD36-positive TBCs from Stim1 -/- mice failed to release serotonin, and Stim1 -/- mice lost the spontaneous preference for fat that was observed in wild-type animals. Our results suggest that fatty acid-induced Ca 2+ signaling, regulated by STIM1 via CD36, might be implicated in oro-gustatory perception of dietary lipids and the spontaneous preference for fat. Source

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