Unite dhemovigilance

Sainte-Marguerite, France

Unite dhemovigilance

Sainte-Marguerite, France

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Leo-Kodeli S.,Center hospitalier regional dOrleans | Renaudier P.,Agence regionale de sante Lorraine | Lassale B.,Unite dhemovigilance
Transfusion Clinique et Biologique | Year: 2014

Although notification of post-transfusion hemosiderosis is mandatory since 1994 among the French hemovigilance network, it is so far largely under reported. Patients and methods: We screened 42,443 patients hospitalized for blood diseases in France in 2009 and 2010 and determined which patients had received more than 20 PRC. Among them, we selected those having at least one measure of serum ferritin, and subsequently those which ferritin was greater than or equal to 1000. ng/mL. Results: Three thousand eight hundred and twelve patients (9%) received more than 20 PRC, 1935 (4.5%) had a ferritin assay, which was increased in 1216 patients (2.9%). Eight hundred and eighty-one patients underwent an hemovigilance report form. Forty-nine percent had low-risk myelodysplasia or acute leukemia, 7% hemoglobinopathies. Hemosiderosis was asymptomatic for 680 patients (77%), serious 188 (88%) and life-threatening for 11 (1%). Two patients died of terminal heart failure. The most severe hemosiderosis (≥ grade 2) were low-risk myelodysplasia and idiopathic aplastic anemia. Ninety-two percent of thalassemia patients and 46% of sickle cell anemia patients received an iron chelator. For low-risk myelodysplastic syndromes and idiopathic aplastic anemia, 228 of the 317 patients whose treatment is known and who could benefit from iron chelation (72%) have not received it. Conclusion: These results encourage seeking optimal transmission of information (over 20 CGR) to the clinician, and prolonging hemovigilance action towards a more comprehensive statement of post-transfusion hemochromatosis. © 2014 Elsevier Masson SAS.


PubMed | Agence regionale de sante Lorraine, Unite dhemovigilance and Center hospitalier regional dOrleans
Type: Journal Article | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2014

Although notification of post-transfusion hemosiderosis is mandatory since 1994 among the French hemovigilance network, it is so far largely under reported.We screened 42,443 patients hospitalized for blood diseases in France in 2009 and 2010 and determined which patients had received more than 20 PRC. Among them, we selected those having at least one measure of serum ferritin, and subsequently those which ferritin was greater than or equal to 1000 ng/mL.Three thousand eight hundred and twelve patients (9%) received more than 20 PRC, 1935 (4.5%) had a ferritin assay, which was increased in 1216 patients (2.9%). Eight hundred and eighty-one patients underwent an hemovigilance report form. Forty-nine percent had low-risk myelodysplasia or acute leukemia, 7% hemoglobinopathies. Hemosiderosis was asymptomatic for 680 patients (77%), serious 188 (88%) and life-threatening for 11 (1%). Two patients died of terminal heart failure. The most severe hemosiderosis ( grade 2) were low-risk myelodysplasia and idiopathic aplastic anemia. Ninety-two percent of thalassemia patients and 46% of sickle cell anemia patients received an iron chelator. For low-risk myelodysplastic syndromes and idiopathic aplastic anemia, 228 of the 317 patients whose treatment is known and who could benefit from iron chelation (72%) have not received it.These results encourage seeking optimal transmission of information (over 20 CGR) to the clinician, and prolonging hemovigilance action towards a more comprehensive statement of post-transfusion hemochromatosis.


Delbosc A.,Hemovigilance | Lafeuillade B.,Hemovigilance | Petermann R.,Direction des laboratoires et des controles | Eb F.,Laboratoire Of Bacteriologie | Ounnoughene N.,Unite dhemovigilance
Transfusion Clinique et Biologique | Year: 2011

Purpose of the study: Transfusion transmitted bacterial infection is an adverse reaction occurring in a patient during blood transfusion and due to the presence of bacteria in the blood component. For each transfusion transmitted bacterial infection suspicion, clinical and biological investigations should allow to either affirm the accountability of the transfused product in the occurrence of the infection (accountability score 4) or exclude it (accountability score 0). However, among 60,175 adverse reaction sheets extracted from the French e-FIT database (AFSSAPS), 143 are classified as transfusion transmitted bacterial infection diagnosis and 97 of them show a score of accountability 2 (possible). This study aims to analyze these 97 adverse reaction sheets and search for the reasons that led the haemovigilance network actors not to refine the degree of accountability in line with an exclusion or a confirmation of transfusion origin. Method: During collective reading sessions, each adverse reaction sheet among the 97 extracted was re-analyzed with an accountability criteria grid, built beforehand, and proposed in the technical guide sheet for transfusion transmitted bacterial infection (e-Fit AFSSAPS). Results: Among the 97 analyzed adverse reaction sheets with a score accountability of 2: 12.4 % were considered as " non-analysable" ; 54% were reclassified in another diagnosis category: non haemolytic febrile reaction (n= 12), unknown diagnosis (n= 17); patient infection before transfusion (n= 23); blood component's " smear" (n= 9); retrograde contamination of blood component (n= 5). Finally, only 18.5% adverse reaction sheets (n= 18) were maintained with a true diagnosis of transfusion transmitted bacterial infection an accountability score of 2. These cases were in agreement with those described in number 2, 3 or 4 in the annex sheet " Fiche Technique TTBI" 70% of adverse reaction sheets reclassified under another diagnosis as transfusion transmitted bacterial infection had been declared between 2000 and 2004. In order to improve transfusion transmitted bacterial infection suspicions diagnosis approach and to guide the French haemovigilance network in the investigations following a transfusion transmitted bacterial infection suspicion, the group propose recommendations after each adverse reaction sheets category analysis. Conclusion: The improvement measures taken as part of the French haemovigilance declaration framework allowed to perfect the data quality of transfusion transmitted bacterial infection. Progresses are still to be made to improve clinical and biological declaration, in order to precise the accountability of a blood component in the occurrence of an adverse transfusion transmitted bacterial infection effect. Tracking transfusion transmitted bacterial infection notifications by a group of experts at the national level is still recommended. © 2010 Elsevier Masson SAS.


Lassale B.,Unite dhemovigilance | Besse-Moreau M.,ARS Limousin | Aullen J.-P.,avenue de Salonique
Transfusion Clinique et Biologique | Year: 2014

Blood transfusion is currently a delegated medical act in patient care services. Following severe adverse events, hemovigilance now disposes of a dense regulation. Data collection and analysis in the national hemovigilance "e-FIT" database allow detection of errors or malfunctions in the transfusion act. Blood transfusion safety depends onthe strict respect ofprocesses from the prescription of blood products and required patient immuno-hematologyexams to the administration of blood products and follow-up of the patient. In the circularrelative tothe transfusion act, many steps of the transfusion process, less explicit, can be interpreted differently by health care professionals and thus lead to errors or severe adverse events. Standardization ofprocedures for the transfusion actand its surveillance wouldincrease their safety and avoid potential risks for the patient. © 2014 Elsevier Masson SAS.


Damais-Cepitelli A.,groupe hospitalier du Havre | Lassale B.,Unite dhemovigilance
Transfusion Clinique et Biologique | Year: 2014

Blood transfusion is currently a delegated medical act in patient care services. Blood transfusion safety depends onthe strict respect ofprocesses from the prescription of blood products and required patient immuno-hematologyexamsto the administration of blood products and follow-up of the patient. We conducted a survey among haemovigilance correspondents to establish the documents needed to practice blood transfusion. Blood products delivery depends on the hospitals local organizations and blood products traceability relies on hospitals levels of computerization. We notice heterogeneous practices. Consequently, an updating of the December 15th 2003 circular relative to the transfusion act seems necessary and could thus lead to blood transfusions homogenous practices. © 2014 Elsevier Masson SAS.


Grolleau N.,Ecole de sages femmes | Lietard C.,Service de sante publique et epidemiologie | Lebdiri B.,Ecole de sages femmes | Le Niger C.,Unite dhemovigilance
Transfusion Clinique et Biologique | Year: 2015

Objectives: This regional study aims to evaluate the transfusion knowledge of midwives in 22 Brittany maternity hospitals. Materials and methods: A multicentre, descriptive and comparative study used a questionnaire consisting in 16 theoretical questions about transfusion and questions being carried out. The analysis used the rate of correct answers and a pondered coefficient has been assigned to the different questions to evaluate the level of midwife knowledge. Results: Twenty-two maternity hospitals participated in the study and 238 returned questionnaires could be analysed, a return rate of 36%. The rate of correct answers was between 5 and 98% depending on the questions; for example, the rate of correct answers of the ultimate control's reading varied between 64 and 98% and revealed that 5 to 7% of midwives would validate an incompatible transfusion. The average score was 31/50 with a minimum of 7/50 and a maximum of 44/50. Three statically significant links have been found according to the last year of training specific to blood transfusion, the graduation year and the level of maternity. Conclusion: This study revealed an insufficient knowledge of the transfusion among midwives and raised prospects, which could lead to an improvement of training courses offered to midwives. © 2015 Elsevier Masson SAS.


PubMed | avenue de Salonique, ARS Limousin and Unite dhemovigilance
Type: Journal Article | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2014

Blood transfusion is currently a delegated medical act in patient care services. Following severe adverse events, hemovigilance now disposes of a dense regulation. Data collection and analysis in the national hemovigilance e-FIT database allow detection of errors or malfunctions in the transfusion act. Blood transfusion safety depends on the strict respect of processes from the prescription of blood products and required patient immuno-hematology exams to the administration of blood products and follow-up of the patient. In the circular relative to the transfusion act, many steps of the transfusion process, less explicit, can be interpreted differently by health care professionals and thus lead to errors or severe adverse events. Standardization of procedures for the transfusion act and its surveillance would increase their safety and avoid potential risks for the patient.


PubMed | groupe hospitalier du Havre and Unite dhemovigilance
Type: Journal Article | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2014

Blood transfusion is currently a delegated medical act in patient care services. Blood transfusion safety depends on the strict respect of processes from the prescription of blood products and required patient immuno-hematology exams to the administration of blood products and follow-up of the patient. We conducted a survey among haemovigilance correspondents to establish the documents needed to practice blood transfusion. Blood products delivery depends on the hospitals local organizations and blood products traceability relies on hospitals levels of computerization. We notice heterogeneous practices. Consequently, an updating of the December 15th 2003 circular relative to the transfusion act seems necessary and could thus lead to blood transfusions homogenous practices.


PubMed | Service de sante publique et epidemiologie, Ecole de sages femmes and Unite dhemovigilance
Type: Comparative Study | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2015

This regional study aims to evaluate the transfusion knowledge of midwives in 22 Brittany maternity hospitals.A multicentre, descriptive and comparative study used a questionnaire consisting in 16 theoretical questions about transfusion and questions being carried out. The analysis used the rate of correct answers and a pondered coefficient has been assigned to the different questions to evaluate the level of midwife knowledge.Twenty-two maternity hospitals participated in the study and 238 returned questionnaires could be analysed, a return rate of 36%. The rate of correct answers was between 5 and 98% depending on the questions; for example, the rate of correct answers of the ultimate controls reading varied between 64 and 98% and revealed that 5 to 7% of midwives would validate an incompatible transfusion. The average score was 31/50 with a minimum of 7/50 and a maximum of 44/50. Three statically significant links have been found according to the last year of training specific to blood transfusion, the graduation year and the level of maternity.This study revealed an insufficient knowledge of the transfusion among midwives and raised prospects, which could lead to an improvement of training courses offered to midwives.


PubMed | Brest University Hospital Center, British Petroleum, CRENO Bretagne, Service de sante publique et epidemiologie and 2 more.
Type: Case Reports | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2014

Bacterial infections are uncommon complications of the blood products transfusion but they are potentially serious. Many advances have been done over the past few years to guarantee the microbiological security of blood products as the donors selection with a medical talk, the derivation of the first 30 millilitres blood during the donation, the deleucocytation of blood products But in spite of these advances, cases of bacterial infection always remain. The purpose of this study was to point out the platelet concentrates transfusion-transmitted bacterial infection with Streptococcus gallolyticus and the unusual consequence for the donor by uncovering an asymptomatic rectal neoplastic tumor. This study as raised as to whether the usefulness of systematic bacterial inactivation in the platelets concentrates.

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