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Demoncheaux J.-P.,Direction Interarmees du Service de Sante | Michel R.,Center Depidemiologie Et Of Sante Publique Des Armees | Mazenot C.,Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes URMITE | Duflos G.,Agence nationale de securite sanitaire de lalimentation | And 4 more authors.
Epidemiology and Infection | Year: 2012

On 26 November 2010, an outbreak of scombroid fish poisoning occurred in the French Armed Forces in Dakar, Senegal. This chemical intoxication, due to high histamine concentration in fish, is often mistaken for an allergic reaction. A case-control study was undertaken including the 71 cases and 78 randomly selected controls among lunch attendees. The usual symptoms for scombroid fish poisoning were observed in cases, i.e. flushing (85·9%), headache (83·1%), rapid/weak pulse (59·1%) and diarrhoea (47·9%). Symptoms occurred from within a few minutes to up to 3 h following the meal. Most patients quickly recovered with antihistamine and/or symptomatic treatment. Tuna was the only food item positively associated with illness (odds ratio 36·3, 95% confidence interval 6·3- 210·0), with the risk of illness increasing with the quantity of fish consumed. No bacterial contamination was found in leftover food, but histamine concentration in tuna was found to be 4900 mg/kg, almost 50-fold higher than the concentration allowed by European regulations. This report is unique because of the large size of the case series - to our knowledge, the largest event of scombroid fish poisoning ever reported - and the chemical and bacteriological analyses results obtained on leftover food. © 2011 Cambridge University Press. Source


Sassi M.,Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes URMITE | Robert C.,Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes URMITE | Raoult D.,Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes URMITE | Drancourt M.,Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes URMITE
Standards in Genomic Sciences | Year: 2013

Mycobacterium simiae is a nontuberculosis mycobacterium causing pulmonary infections in both immunocompetent and imunocompromized patients. We announce the draft genome sequence of M. simiae DSM 44165T. The 5,782,968-bp long genome with 65.15% GC content (one chromosome, no plasmid) contains 5,727 open reading frames (33% with unknown function and 11 ORFs sizing more than 5000 -bp), three rRNA operons, 52 tRNA, one 66-bp tmRNA matching with tmRNA tags from Mycobacterium avium, Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium microti, Mycobacterium marinum, and Mycobacterium africanum and 389 DNA repetitive sequences. Comparing ORFs and size distribution between M. simiae and five other Mycobacterium species M. simiae clustered with M. abscessus and M. smegmatis. A 40-kb prophage was predicted in addition to two prophagelike elements, 7-kb and 18-kb in size, but no mycobacteriophage was seen after the observation of 106 M. simiae cells. Fifteen putative CRISPRs were found. Three genes were predicted to encode resistance to aminoglycosides, betalactams and macrolidelincosamidestreptogramin B. A total of 163 CAZYmes were annotated. M. simiae contains ESX-1 to ESX-5 genes encoding for a type-VII secretion system. Availability of the genome sequence may help depict the unique properties of this environmental, opportunistic pathogen. Source

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