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Ariana, Tunisia

Tlili N.,Laboratoire Of Biochimie | Trabelsi H.,Tunis el Manar University | Renaud J.,University of Ottawa | Khaldi A.,Unite de Recherche | And 2 more authors.
JAOCS, Journal of the American Oil Chemists' Society | Year: 2011

The goal of this study is to evaluate for the first time the composition of triacylglycerols (TAG) using ESI-TOF-MS and phospholipids species using HPLC-ESI-TOFMS of two Capparis spinosa seed oil populations. Results show that LOO, LOP, LLO, OOO, PLL and POO were the major molecular species of triacylglycerol detected in caper seeds; where L represents linoleic acid; O, oleic acid; and P, palmitic acid. The TAG composition was significantly different among the two C. spinosa populations. In Ghar el Melh population, LOO (15.7%) was detected as the dominant TAG molecular species, followed by LOP (13.2%), LLO (12.0%) and OOO (11.4%); while, the dominant fraction was LLO (14.2%) followed by LOO (14.1%), LOP (11.5%) and PLL (10.5%) in Chouigui samples. The major component in the phospholipids fraction was phosphatidylinositol (ca. 54-91%), followed by phosphatidylglycerol, phosphatidylethanolamine and phosphatidic acid. A variety of molecular species within each class were identified. The major component in all phospholipids species contains a C-18:1 lipid chain. C16:0/C18:2-PI (ca. 28-31%) was the most abundant PI. PG species were mainly C18:2/ C18:1-PG (25-32%). The major PE was C18:1/C18:1-PE (44-75%). The major PA species was C18:1/C18:1-PA (22-24%). © AOCS 2011.

Errais E.,CNRS Hydrology and Geochemistry Laboratory of Strasbourg | Duplay J.,CNRS Hydrology and Geochemistry Laboratory of Strasbourg | Elhabiri M.,CNRS Molecular Chemistry Laboratory | Khodja M.,Sonatrach | And 3 more authors.
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2012

Clay minerals are efficient adsorbent for dyes due to their colloidal properties. A Tunisian raw clay (Fouchana) composed of different species of clay minerals (kaolinite, smectite and minor illite) has shown efficiency for removal of anionic dye Reactive Red 120 (RR120) from aqueous solutions. In order to provide a better understanding of the role played by the different clay species in Fouchana, as well as the nature of the adsorption processes which are involved, a comparative study was conducted using standard clays, namely kaolinite KGa-2, smectite SWy-1 and illite IMt-2. Batch adsorption experiments were performed at ambient temperature and pH of the dye solutions. Acido-basic properties of the solid surfaces, electrophoretic mobility of particles, cation exchange capacity, amount of exchangeable cations and specific surface were investigated. Principal component analysis was used to highlight the influence of the physicochemical characteristics of the clay minerals in the adsorption behavior. The results show that for the conditions set in this study, kaolinite in the Fouchana raw clay plays a major role in anionic dye adsorption, mainly due to its acidic surface sites, but also to exchangeable aluminum (III) cations acting as bridges between the clay mineral and the dye molecules. Smectite and illite most likely play a secondary role by adsorption on exchangeable calcium (II) and dissociated Al (III). OH groups. © 2012 Elsevier B.V.

Bekir J.,CNRS Laboratory for Molecular and Photochemical Reactions | Cazaux S.,CNRS Laboratory for Molecular and Photochemical Reactions | Mars M.,Unite de Recherche | Bouajila J.,CNRS Laboratory for Molecular and Photochemical Reactions
Industrial Crops and Products | Year: 2016

Punica granatum (pomegranate, Punicaceae family) has been known as medicinal plant with potential biological activities. The present study was carried out to investigate the cholinesterase and hyperglycemic inhibitory activities of the flowers of pomegranate collected in South of Tunisia. The plant extracts were prepared with the ethanol solvent and the biological activities were variety and concentration dependent. Espagnoule variety with the lowest IC50 value of 2.70±0.10μg/mL exhibited the strongest acetylcholinesterase inhibitory activity. It was found that Rafrafi (IC50=4.0±0.11μg/mL) and Garsi varieties (IC50=4.5±0.21μg/mL) exhibited the strongest butyrylcholinesterase inhibitory activity as compared with the reference drug, galanthamine (3.74±0.28μg/mL). For anti-hyperglycemic activity, the Rafrafi variety was the most potent against α-glucosidase activity with the lowest IC50 value of 29.77±1.50μg/mL. Only Zaghwani variety exhibited lower anti-α-amylase activity (IC50=185.92±2.00μg/mL) whereas other pomegranate varieties were not active. © 2015 Elsevier B.V.

Attention deficit/hyperactivity disorder (ADHD) has prevalence between 3% and 7% in childhood and adolescence. 80% of patients have comorbidities: developmental disorder, coordination disabilities, emotional disorder, conduct disorder or oppositional-defiant disorder. Patients with ADHD have also executive difficulty (for instance attention regulation, inhibition, working memory, planning and organization). Treatment of ADHD includes a combination of multimodal modalities including drugs, psychotherapy and psychosocial. Stimulants treatments for young ADHD athletes need regular monitoring checking efficient dose and effects on ADHD symptoms and side effects. The physician has to keep in mind risk of abuse drug intake, especially by young sportsman of elite subjected to pressures of results. Atomoxetine (ATX/Srattera®) is now second choice drug since approval by the FDA in december 2002. This drug is a non stimulant medication with noradrenergic action over 24 hours and without risk of abuse. ATX may be particularly useful for some young athletes with ADHD as alternative to stimulants. More researches are needed to explore specific effects of stimulants and atomoextine for athletes with ADHD regarding clinical profiles and taking into consideration the kind of sport that is practised.

Mehri S.,University of Monastir | Mahjoub S.,Unite de Recherche | Finsterer J.,Danube University Krems | Zaroui A.,Service des Explorations Fonctionnelles Cardiologiques | And 3 more authors.
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System | Year: 2011

Acute myocardial infarction (AMI) is a multifactorial disease influenced by environmental and genetic factors. The aim of this study was to assess the association of angiotensin II type 1 receptor (ATR1) gene polymorphisms with AMI as well as to evaluate the role of serum angiotensin-converting enzyme (ACE) activity and that of cardiac troponin I (cTnI) in Tunisian AMI patients. One hundred and eighteen AMI patients were compared to 150 healthy controls. ATR1 genotypes were determined by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The ATR1 A1166C polymorphism was significantly associated with AMI (p = 0.024). CC genotype and C allele frequencies were associated with increased AMI risk [CC vs. AC and AA: OR = 2.06; p = 0.045; 95 % CI (1.02-4.18); C vs. A: OR = 1.68; p = 0.004; 95 % CI (1.17-2.41)]. By multivariate logistic regression analysis, CC genotype, hypertension, diabetes, serum ACE activity and peak-cTnI were significant independent predictors of AMI. Increased serum ACE activity and cTnI peak levels were associated with the CC genotype in AMI patients. In conclusion, the ATR1 A1166C polymorphism is associated with AMI and the CC genotype associated with increased ACE activity and cTnI levels appear to predispose for AMI risk. © SAGE Publications 2011.

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