Belum V.R.,Sloan Kettering Cancer Center |
Washington C.,Sloan Kettering Cancer Center |
Pratilas C.A.,Sloan Kettering Cancer Center |
Sibaud V.,Institute Claudius Regaud |
And 2 more authors.
Pediatric Blood and Cancer | Year: 2015
Background: The dermatologic adverse events (AEs) of various molecularly targeted therapies are well-described in adult cancer patients. Little has been reported on the incidence and clinical presentation of such AEs in pediatric patients with cancer. To address this gap, we analyzed the dermatologic AEs reported across clinical trials of targeted anticancer therapies in pediatric patients. Procedures: We conducted an electronic literature search (PubMed, American Society of Clinical Oncology annual meetings' abstracts, ClinicalTrials.gov, NCI's Pediatric Oncology Branch webpage) to identify clinical trials involving targeted anticancer therapies that reported dermatologic AEs in their safety data. Studies were limited to the pediatric population, monotherapy trials (oncology), and English language publications. Results: Pooled data from 19 clinical studies investigating 11 targeted anticancer agents (alemtuzumab, rituximab, imatinib, dasatinib, erlotinib, vandetanib, sorafenib, cabozantinib, pazopanib, everolimus, and temsirolimus) were analyzed. The most frequently encountered dermatologic AEs were rash (127/660; 19%), xerosis (18/100; 18%), mucositis (68/402; 17%), and pruritus (12/169; 7%). Other AEs included pigmentary abnormalities of the skin/hair (13%), hair disorders (trichomegaly, hypertrichosis, alopecia, and madarosis; 14%), urticaria (7%), palmoplantar erythrodysesthesia (7%), erythema, acne, purpura, skin fissures, other 'unknown skin changes', exanthem, infection, flushing, telangiectasia, and photosensitivity. Conclusion: This study describes the dermatologic manifestations of targeted anticancer therapy-related AEs in the pediatric population. Since these AEs are often associated with significant morbidity, it is imperative that pediatric oncologists be familiar with their recognition and management, to avoid unnecessary dose modifications and/or termination, and to prevent impairments in patients' quality of life. Pediatr Blood Cancer 2015;62:798-806. © 2015 Wiley Periodicals, Inc.
Ruimy R.,University Paris Diderot |
Brisabois A.,Unite |
Bernede C.,University of Versailles |
Skurnik D.,University Paris Diderot |
And 9 more authors.
Environmental Microbiology | Year: 2010
Resistance to antibiotics is a major public health problem which might culminate in outbreaks caused by pathogenic bacteria untreatable by known antibiotics. Most of the genes conferring resistance are acquired horizontally from already resistant commensal or environmental bacteria. Food contamination by resistant bacteria might be a significant source of resistance genes for human bacteria but has never been precisely assessed, nor is it known whether organic products differ in this respect from conventionally produced products. We showed here, on a large year-long constructed sample set containing 399 products that, irrespective of their mode of production, raw fruits and vegetables are heavily contaminated by Gram-negative bacteria (GNB) resistant to multiple antibiotics. Most of these bacteria originate in the soil and environment. We focused on nonoxidative GNB resistant to third-generation cephalosporins, because of their potential impact on human health. Among them, species potentially pathogenic for immunocompetent hosts were rare. Of the products tested, 13% carried bacteria producing extended - spectrum beta-lactamases, all identified as Rahnella sp. which grouped into two phylotypes and all carrying the blaRAHN gene. Thus, both organic and conventional fruits and vegetables may constitute significant sources of resistant bacteria and of resistance genes. © 2009 Society for Applied Microbiology and Blackwell Publishing Ltd.
Sriti J.,Unite |
Wannes W.A.,Unite |
Talou T.,ENSIACET |
Mhamdi B.,Unite |
And 2 more authors.
JAOCS, Journal of the American Oil Chemists' Society | Year: 2010
Coriander (Coriandrum sativum L.) seeds were harvested from the region of Korba (North-East Tunisia) in order to characterize their fatty acids, phytosterols, toc-opherols and tocotrienols (tocols) profiles. Nine fatty acids, with petroselinic acid accounting for 76.6% of the total fatty acids, followed by linoleic, oleic and palmitic acids, accounting for 13.0, 5.4 and 3.4%, respectively, of the total fatty acids were identified. Neutral lipids (NLs) were mainly composed of triacylglycerols (98.4%). Polar lipids were mainly composed of phosphatidylcholine as the major phospholipid (PL) subclass, whereas digalactosyldia-cylglycerol was the major galactolipid (GL). Total sterols content was estimated to be 36.93 mg/g oil. Stigmasterol accounted for 29.5% of the total sterols. Other rEPResentative sterols were β-sitosterol, A7-stigmasterol and A5, 24- stigmastadienol, which accounted for 24.8, 16.3 and 9.2%, respectively. Gamma-tocotrienol was the predominant tocol at 238.40 μg/g seed oil. This was equivalent to 72.8% of the total tocols followed by y-tocopherol (8.06%) and α-tocopherol (7.6%). © 2009 AOCS.
Amari M.,Unite |
Ghouili J.,University of Moncton |
Canadian Conference on Electrical and Computer Engineering | Year: 2011
Several converter configurations have been proposed in literature to achieve fuel-cell power conversion systems. In this paper a new converter high frequency unidirectional DC-DC was proposed simulated and realized. This last one allows to obtain an output voltage is 550V from an input voltage of 28V (output voltage of fuel-cell). The control strategy used is the shift phase of the full bridge converter. In this case, we minimize the switching losses. We replaced the converter at two levels of voltage by only one full bridge converter using two planar transformers in high frequency (the primary are coupled in parallel and the secondary are in series). Indeed, we minimized the size and the weight of the converter. Simulation results are carried out with Matbab/Simulink Software. Finally the experimental results are given and compared to the simulation ones. © 2011 IEEE.
Nursing standard (Royal College of Nursing (Great Britain) : 1987) | Year: 2014
We at Unite are opposed to the proposal from the Nursing and Midwifery Council (NMC) to increase the registration fee from £100 a year to £120 in March next year (News July 30 and August 6).
PubMed | Unite.
Type: Letter | Journal: Nursing standard (Royal College of Nursing (Great Britain) : 1987) | Year: 2014
We at Unite are opposed to the proposal from the Nursing and Midwifery Council (NMC) to increase the registration fee from 100 a year to 120 in March next year (News July 30 and August 6).