Poma A.,University of LAquila |
Ragnelli A.M.,University of LAquila |
De Lapuente J.,Unitat de Toxicologia Experimental y Ecotoxicologia UTOX |
Ramos D.,Unitat de Toxicologia Experimental y Ecotoxicologia UTOX |
And 5 more authors.
Journal of Immunology Research | Year: 2014
The attention on CeONPs environmental and in vivo effects is due to their presence in diesel exhaust and in diesel filters that release a more water-soluble form of ceria NPs, as well as to their use for medical applications. In this work, acute and subacute in vivo toxicity assays demonstrate no lethal effect of these NPs. Anyhow, performing in vivo evaluations on CD-1 mouse systems, we demonstrate that it is even not correct to assert that ceria NPs are harmless for living systems as they can induce status of inflammation, revealed by hematological-chemical-clinical assays as well as histological and TEM microscope observations. TEM analysis showed the presence of NPs in alveolar macrophages. Histological evaluation demonstrated the NPs presence in lungs tissues and this can be explained by assuming their ability to go into the blood stream and lately into the organs (generating inflammation). © 2014 Anna Poma et al.