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Santa Maria della Versa, Italy

Galli G.,University of Florence | Ragazzoni A.,Unita Operativa di Neurologia | Viggiano M.P.,University of Florence
Alzheimer's and Dementia | Year: 2010

Background: Our goal was to verify whether behavioral and electrophysiological measures of visual object priming can differentiate between patients with mild cognitive impairment (MCI) and elderly control subjects. Methods: An identification-priming paradigm with spatially filtered stimuli was used. Subjects were presented with complete forms of the stimuli in the study phase. In the subsequent test phase, studied items were repeated in an ascending sequence of spatially filtered stimuli, following a coarse-to-fine order. Event-related potentials and behavioral measures were recorded. Results: Behavioral priming effects were observed in the elderly and in MCI participants. None of the well-known event-related potential indices of stimulus repetition emerged in the MCI group. In elderly controls, stimulus repetition was associated with a frontal modulation, likely indexing familiarity. Priming effects in the MCI group were probably based on memory mechanisms altered by degenerative pathology. Conclusions: Event-related potentials hold great potential for the early detection of subjects at risk for dementia, because they may reveal possible functional brain abnormalities that are not detectable at clinical or behavioral levels. © 2010 The Alzheimer's Association. All rights reserved. Source

Picetti E.,Servizio Anestesia Rianimazione | Antonini M.V.,Servizio Anestesia Rianimazione | Bartolini Y.,University of Parma | DeAngelis A.,University of Parma | And 4 more authors.
Neurocritical Care | Year: 2016

Background: The aim of this study was to evaluate the association between fever after the first days of ICU stay and neurological outcome after cardiac arrest (CA). Methods: We retrospectively analyzed CA patients admitted to intensive care unit (ICU). Inclusion criteria: age ≥18 years, Glasgow Coma Scale score ≤8 at ICU admission and assessment of body core temperature (BCT) using bladder or intravascular probes. Exclusion criteria: ICU length of stay (LOS) <3 days and pregnancy. The primary endpoint was neurological outcome assessed with Cerebral Performance Category (CPC) scale 6 months after CA. Results: One hundred thirty-two patients were analyzed. Fever was present in 105 (79.6 %) patients. Variables associated with unfavorable outcome were (1) older age (p < 0.0025); (2) non-shockable cardiac rhythms (p < 0.0001); (3) higher Simplified Acute Physiology Score (SAPS) II (p < 0.0001); (4) pupillary abnormalities at ICU admission (p < 0.018); and (5) elevated degree of maximal BCT (Tmax) during ICU stay (p < 0.046). After multivariate analysis, Tmax maintained a significant relationship with neurological outcome. An increase of 1 °C in Tmax during ICU stay decreased the odds ratio for a favorable outcome by a factor of 31 % (p < 0.001). Moreover, we discovered a significant interaction between the day of Tmax (t-Tmax) and Tmax (p = 0.004); the later Tmax occurs, the more deleterious effects are observed on outcome. Conclusions: Fever is frequent after CA, and Tmax in ICU is associated with worsened neurological outcome. This association becomes stronger as the timing of Tmax extends further from the CA. © 2016, Springer Science+Business Media New York. Source

Tomasino B.,IRCCS E. Medea | Marin D.,IRCCS E. Medea | Maieron M.,Fisica Medica A.O.S. Maria della Misericordia | Ius T.,Unita Operativa di Neurochirurgia | And 4 more authors.
Cortex | Year: 2013

The present study explored the functional neuroanatomy of Foreign Accent Syndrome (FAS) in an Italian native speaker who developed an altered speech rhythm and melody following a circumscribed tumour to the left precentral gyrus. Structural, functional, fibre tracking and intraoperative findings were combined. No signs of dysarthria, apraxia of speech, or aphasia nor other cognitive deficits were detected, except for the fact that the patient was perceived as a non-native speaker. The patient fMRI maps were compared with a control group of 12 healthy controls. During counting, sentences and pseudoword pronunciation the patient showed an additional increased sparse activation in areas around the pre/postcentral gyrus corresponding to those involved in phonation (i.e., larynx motor area). The intraoperative cortical stimulation mapping evidenced a mouth motor representation close to the tumour, a motor type of speech arrest site just below it, and anteriorly a proper speech arrest site. Our results are discussed within the current neurolinguistic models of speech production, and emphasize the importance of the primary motor cortex. We argue that this FAS case should be thought of as a disorder of the feedforward control commands, in particular of the articulator velocity and position maps which are hypothesized to lie along the caudoventral portion of the precentral gyrus. © 2011 Elsevier Ltd. Source

Parma V.,University of Padua | Zanatto D.,University of Padua | Straulino E.,University of Padua | Scaravilli T.,Unita Operativa di Neurologia | Castiello U.,University of Padua
Frontiers in Neurology | Year: 2014

The performance of patients with vascular parkinsonism (VPD) on a reach-to-grasp task was compared with that of patients affected by idiopathic Parkinson's disease (IPD) and age-matched control subjects. The aim of the study was to determine how patients with VPD and IPD compare at the level of the kinematic organization of prehensile actions. We examined how subjects concurrently executed the transport and grasp components of reach-to-grasp movements when grasping differently sized objects. When comparing both VPD and IPD groups to control subjects, all patients showed longer movement duration and smaller hand opening, reflecting bradykinesia and hypometria, respectively. Furthermore, for all patients, the onset of the manipulation component was delayed with respect to the onset of the transport component. However, for patients with VPD this delay was significantly smaller than that found for the IPD group. It is proposed that this reflects a deficit - which is moderate for VPD as compared to IPD patients - in the simultaneous (or sequential) implementation of different segments of a complex movement. Altogether these findings suggest that kinematic analysis of reach-to-grasp movement has the ability to provide potential instruments to characterize different forms of parkinsonism. © 2014 Parma, Zanatto, Straulino, Scaravilli and Castiello. Source

Tomelleri G.,Unita Operativa di Neurologia | Zanoni T.,Unita Operativa di Neurologia | Colato C.,Unita Operativa di Anatomia e Istologia Patologica | Bovi P.,Unita Operativa di Neurologia | Moretto G.,Unita Operativa di Neurologia
Neurological Sciences | Year: 2010

Blue rubber bleb nevus syndrome is a rare vascular disorder characterized by cavernous angiomas of skin and other organs including the gastrointestinal tract. The central nervous system involvement is seldom reported, and neurological symptoms at onset in adulthood are extremely rare. Here, we describe a case of 82-year-old patient presenting multiple skin haemangiomas for some years, who was admitted for a brain hemorrhage. The MRI demonstrated the presence of multiple cavernous angiomas within the cerebral tissue. © Springer-Verlag 2010. Source

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